... Proteinases in the joint: clinical relevance ofproteinases in joint destruction. Arthritis Res Ther 2007, 9:221.5. Yoshihara Y, Nakamura H, Obata K, Yamada H, Hayakawa T, Fujikawa K,Okada Y: Matrix ... of the study, and participated in its design, in coordination and interpretation of the data and in drafting the manuscript. All authors read and approved the final manuscript.Competing interests The ... analysis of the damage in cartilage, ankle sec-tions were stained with Toluidine blue and Safranin-Ofollowing the standard methodology. To determinateosteoclast activity, staining for tartrate-resistant...