... secretion may be important fordownregulating the endotoxin-induced inflammatory cytokinestorm that characterizes early stages of bacterial sepsis. In addition, IL-10 may also finely modulate the activity ... (e.g. hydralazine and pro-cainamide) are capable of blocking methyltransferase activity[117], and some stimulatory effects of DNA may not requireTLR9 receptor at all, as recently noticed in TLR9-deficientcells ... worsened lymphoproliferation, auto-antibody production and end-organ disease, suggesting thattype I IFNs may play a protective role, at least in some animalmodels of autoimmunity.Curiously, immature...