Biochemical, Genetic, and Molecular Interactions in Development - part 8 pps

... F., and Kassem, M. (2001) 1,25-Dihydroxyvitamin D3 stimulates the pro- duction of insulin-like growth factor-binding proteins-2, -3 and -4 in human bone marrow stromal cells. Eur. J. Endo- crinol. ... increases secretion of insulin-like growth factor binding protein-4 (IGFBP-4) by human osteo- blast-like cells in vitro and elevates IGFBP-4 serum levels in vivo. J. Clin. Endo...

Ngày tải lên: 11/08/2014, 17:20

... homology: classical cadherins type I (e.g., E-, N-, P-, R-cadherin), classical cadherins type II (cadherin-6 to -1 2), cadherins found in desmosomes (desmocollins, desmogleins), cadherins with a very short ... U., and Gumbiner, B. (19 98) Nuclear localization signal—independent and importin/karyopherin- —independent nuclear import of beta-catenin. Curr. Biol. 8, 181 –190. 100. Korin...

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... chondrocytes (9). Finally, BMP-2, BMP-4, and BMP-7 are expressed in the precartilaginous mesenchyme ( 28) and were shown to enhance chondro- genesis in vitro (29) and in vivo in chick limb buds ... TGF-`-regulated genes contain either AP-1 sites, such as the PAI-1 (55), TIMP-1 (56), TGF-`ß1 (57), c-Jun ( 58) , and _2(I) collagen (59) or CREB/ATF binding sites, such as fibronec...

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... prolyl 4-hydroxylase, prolyl 3-hydroxylase, and lysyl hydrox- ylase, catalyze the formation of 4-hydroxyproline, 3-hydroxyproline, and hydroxylysine residues in -X-Pro-Gly, -Pro-4Hyp-Gly-, and -X-Lys-Gly- ... chains, called _ chains, and contain at least one unique triple-helical domain with repeating -Gly-X-Y- sequences in each of the constituent chains. The presence of glycine,...

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... with Xwnt -8 , showing a direct interaction between Frzb and Wnts (84 ), and Frzb blocks the axis-inducing activity of Xwnt -8 and mouse Wnt-1 when coinjected on the ven- tral side of cleaving embryos, ... can bind to Xwnt-3a, Xwnt-5, and Xwnt -8 in vitro but only interacts with Xwnt -8 in the embryo (89 ). Similar results have been obtained for Frzb2 and Sizzled 2 (90), maki...

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... the BMP-2-induced increase in the Bax/Bcl-2 ratio, caspase activity, and apoptosis. In contrast, the cAMP-dependent protein kinase A (PKA) inhibitor H89, the p 38 MAPK inhibitor SB203 580 , and the ... to identify BMP-induced genes. Osx is a novel zinc finger-containing transcrip- tion factor that is specifically expressed in developing bones. Osx contains a proline- and serine-r...

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... osteogenesis in preclinical and clinical contexts (1,11–16). Naturally-derived BMPs/OPs and recombinant human osteogenic protein-1 (hOP-1), also known as BMP-7, induce osteo- genesis in nonhuman and human ... depending on the experimental design, can (1) main- tain the integrity of the anlagen and the inherent cell and tissue interactions involved in its normal development,...

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... changes in bone modeling and remodeling in response to loading and unloading are initiated by an internal mechanostat that is able to sense strain. In this view, changes in bone remodeling occur in response ... 13365–13371. 80 . Klein-Nulend, J., Burger, E. H., Semeins, C. M., Raisz, L. G., and Pilbeam, C. C. (1997) Pulsating fluid flow stimu- lates prostaglandin release and...

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... Standard developmental toxicity bioassays in rodents include a detailed examination of the near-term fetal skeleton in single-stained (alizarin red for ossified bone) or double-stained (alizarin red ... dpc by using molecular markers. A retinoic acid-responsive transcription factor, Ap-2, (42) and cellular retinoic acid-binding protein-1 Fig. 5. Analysis of the endogenous levels of re...

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... role, 187 , 188 mitogen-activated protein kinase regulation of signaling, 188 , 189 osterix induction, 189 retinoblastoma protein regulation of signaling, 188 signal transduction, 186 , 187 osteoclast ... factor regulation, interferon-a, 203, 204 interleukin-1, 202 interleukin-4, 202 interleukin-6, 202, 203 interleukin-11, 203 macrophage colony-stimulating factor, 200, 201 osteoprotegeri...

Ngày tải lên: 11/08/2014, 17:20