Biochemical, Genetic, and Molecular Interactions in Development - part 8 pps
Biochemical, Genetic, and Molecular Interactions in Development - part 8 pps
... F., and Kassem, M. (2001) 1,25-Dihydroxyvitamin D3 stimulates the pro-
duction of insulin-like growth factor-binding proteins-2, -3 and -4 in human bone marrow stromal cells. Eur. J. Endo-
crinol. ... increases secretion of insulin-like growth factor binding protein-4 (IGFBP-4) by human osteo-
blast-like cells in vitro and elevates IGFBP-4 serum levels in vivo. J. Clin. Endo...
Biochemical, Genetic, and Molecular Interactions in Development - part 1 docx
... homology: classical cadherins type I (e.g., E-, N-, P-, R-cadherin), classical cadherins
type II (cadherin-6 to -1 2), cadherins found in desmosomes (desmocollins, desmogleins), cadherins
with a very short ... U., and Gumbiner, B. (19 98) Nuclear localization signal—independent and importin/karyopherin-
—independent nuclear import of beta-catenin. Curr. Biol. 8, 181 –190.
100. Korin...
Biochemical, Genetic, and Molecular Interactions in Development - part 2 potx
... chondrocytes (9). Finally, BMP-2, BMP-4,
and BMP-7 are expressed in the precartilaginous mesenchyme ( 28) and were shown to enhance chondro-
genesis in vitro (29) and in vivo in chick limb buds ... TGF-`-regulated genes contain either
AP-1 sites, such as the PAI-1 (55), TIMP-1 (56), TGF-`ß1 (57), c-Jun ( 58) , and _2(I) collagen (59)
or CREB/ATF binding sites, such as fibronec...
Biochemical, Genetic, and Molecular Interactions in Development - part 3 pdf
... prolyl 4-hydroxylase, prolyl 3-hydroxylase, and lysyl hydrox-
ylase, catalyze the formation of 4-hydroxyproline, 3-hydroxyproline, and hydroxylysine residues in
-X-Pro-Gly, -Pro-4Hyp-Gly-, and -X-Lys-Gly- ... chains, called _ chains, and contain at least one unique triple-helical domain with
repeating -Gly-X-Y- sequences in each of the constituent chains. The presence of glycine,...
Biochemical, Genetic, and Molecular Interactions in Development - part 4 ppt
... with Xwnt -8 , showing a direct interaction between Frzb and Wnts (84 ),
and Frzb blocks the axis-inducing activity of Xwnt -8 and mouse Wnt-1 when coinjected on the ven-
tral side of cleaving embryos, ... can bind to Xwnt-3a, Xwnt-5, and
Xwnt -8 in vitro but only interacts with Xwnt -8 in the embryo (89 ). Similar results have been obtained
for Frzb2 and Sizzled 2 (90), maki...
Biochemical, Genetic, and Molecular Interactions in Development - part 5 docx
... the BMP-2-induced increase in the Bax/Bcl-2 ratio, caspase
activity, and apoptosis. In contrast, the cAMP-dependent protein kinase A (PKA) inhibitor H89, the
p 38 MAPK inhibitor SB203 580 , and the ... to identify BMP-induced genes. Osx is a novel zinc finger-containing transcrip-
tion factor that is specifically expressed in developing bones. Osx contains a proline- and serine-r...
Biochemical, Genetic, and Molecular Interactions in Development - part 6 docx
... osteogenesis in preclinical and clinical contexts (1,11–16). Naturally-derived
BMPs/OPs and recombinant human osteogenic protein-1 (hOP-1), also known as BMP-7, induce osteo-
genesis in nonhuman and human ... depending on the experimental design, can (1) main-
tain the integrity of the anlagen and the inherent cell and tissue interactions involved in its normal
development,...
Biochemical, Genetic, and Molecular Interactions in Development - part 7 docx
... changes in bone modeling and remodeling in response to loading and unloading are initiated by
an internal mechanostat that is able to sense strain. In this view, changes in bone remodeling occur in
response ... 13365–13371.
80 . Klein-Nulend, J., Burger, E. H., Semeins, C. M., Raisz, L. G., and Pilbeam, C. C. (1997) Pulsating fluid flow stimu-
lates prostaglandin release and...
Biochemical, Genetic, and Molecular Interactions in Development - part 9 potx
... Standard developmental toxicity bioassays in rodents include a detailed examination of the
near-term fetal skeleton in single-stained (alizarin red for ossified bone) or double-stained (alizarin
red ... dpc by using molecular markers. A
retinoic acid-responsive transcription factor, Ap-2, (42) and cellular retinoic acid-binding protein-1
Fig. 5. Analysis of the endogenous levels of re...
Biochemical, Genetic, and Molecular Interactions in Development - part 10 doc
... role, 187 , 188
mitogen-activated protein kinase
regulation of signaling, 188 , 189
osterix induction, 189
retinoblastoma protein regulation
of signaling, 188
signal transduction, 186 , 187
osteoclast ... factor
regulation,
interferon-a, 203, 204
interleukin-1, 202
interleukin-4, 202
interleukin-6, 202, 203
interleukin-11, 203
macrophage colony-stimulating
factor, 200, 201
osteoprotegeri...
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