Biochemical, Genetic, and Molecular Interactions in Development - part 7 docx

... changes in bone modeling and remodeling in response to loading and unloading are initiated by an internal mechanostat that is able to sense strain. In this view, changes in bone remodeling occur in response ... 276 , 13365–13 371 . 80. Klein-Nulend, J., Burger, E. H., Semeins, C. M., Raisz, L. G., and Pilbeam, C. C. (19 97) Pulsating fluid flow stimu- lates prostaglandin relea...

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... at tis- sue and somite boundaries. Development 120, 36 67 3 679 . 102. Novak, A., Shu, C., and Chungyee, L. (1998) Cell adhesion and the integrin-linked kinase regulate the LEF-1 and `- catenin signaling ... homology: classical cadherins type I (e.g., E-, N-, P-, R-cadherin), classical cadherins type II (cadherin-6 to -1 2), cadherins found in desmosomes (desmocollins, desmo...

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... to identify BMP-induced genes. Osx is a novel zinc finger-containing transcrip- tion factor that is specifically expressed in developing bones. Osx contains a proline- and serine-rich transcription ... cytochrome c into the cytosol. Subsequently, BMP-2 increased caspase-9 and caspase-3, -6 , and -7 activity. Inhibition of caspase-9 activity suppressed BMP-2-induced apoptosis. How...

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... inhibitory Smad pro- teins, Smad-6 and Smad -7 (29). Experiments in our laboratories indicate the influence of downstream antagonists of TGF-` signaling, Smad-6 and -7 , at least in heterotopic sites, ... osteogenesis in preclinical and clinical contexts (1,11–16). Naturally-derived BMPs/OPs and recombinant human osteogenic protein-1 (hOP-1), also known as BMP -7 , induce ost...

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... E., Ros, M. A., and Hurle, J. M. (19 97) Role of BMP-2 and OP-1 (BMP -7 ) in programmed cell death and skeletogenesis during chick limb development. Development 124, 1109–11 17. 1 57. Ferrari, D., ... chondrocytes (9). Finally, BMP-2, BMP-4, and BMP -7 are expressed in the precartilaginous mesenchyme (28) and were shown to enhance chondro- genesis in vitro (29) and in...

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... prolyl 4-hydroxylase, prolyl 3-hydroxylase, and lysyl hydrox- ylase, catalyze the formation of 4-hydroxyproline, 3-hydroxyproline, and hydroxylysine residues in -X-Pro-Gly, -Pro-4Hyp-Gly-, and -X-Lys-Gly- ... chains, called _ chains, and contain at least one unique triple-helical domain with repeating -Gly-X-Y- sequences in each of the constituent chains. The presence of glycine,...

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... functional interaction between BMP -7 and the latent TGF-` binding protein family member Fibrillin-2 and suggest that the bioactivity or availability of BMP -7 , like that of TGF-`, may be regulated by interactions ... at least in Cerberus and Caronte includes the BMP-binding region (77 ,78 ). DAN DAN, originally isolated as a putative zinc-finger protein that has tumor-suppressor...

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... development of vitamin D analogs with bone anabolic effects has come into focus ( 271 ). A few recent examples are ED -7 1 ( 272 , 273 ), RO-2 6-9 228 ( 274 ), 26, 2 7- hexafluoro-1,2 5-( OH)2D3 ( 275 ), and 2-methylene- 19-nor-(20S)1,2 5-( OH) 2 D 3 ( 276 ). ... factors and insulin-like growth factor-binding proteins: clinical implica- tions. Clin. Chem. 45, 1384–1390. 165. Conov...

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... Standard developmental toxicity bioassays in rodents include a detailed examination of the near-term fetal skeleton in single-stained (alizarin red for ossified bone) or double-stained (alizarin red ... dpc by using molecular markers. A retinoic acid-responsive transcription factor, Ap-2, (42) and cellular retinoic acid-binding protein-1 Fig. 5. Analysis of the endogenous levels of re...

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... factor regulation, interferon-a, 203, 204 interleukin-1, 202 interleukin-4, 202 interleukin-6, 202, 203 interleukin-11, 203 macrophage colony-stimulating factor, 200, 201 osteoprotegerin, 201 RANKL, 200 transforming ... protein-1 growth hormone, 174 – 176 , 180 parathyroid hormone, 177 , 178 , 181 prostaglandin E2, 176 , 177 , 180 functional overview, 308 loading response, mechanotransduction...

Ngày tải lên: 11/08/2014, 17:20