Biochemical, Genetic, and Molecular Interactions in Development - part 5 docx
Biochemical, Genetic, and Molecular Interactions in Development - part 5 docx
... to identify BMP-induced genes. Osx is a novel zinc finger-containing transcrip- tion factor that is specifically expressed in developing bones. Osx contains a proline- and serine-rich transcription ... cytochrome c into the cytosol. Subsequently, BMP-2 increased caspase-9 and caspase-3, -6 , and -7 activity. Inhibition of caspase-9 activity suppressed BMP-2-induced apoptosis. Ho...
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Biochemical, Genetic, and Molecular Interactions in Development - part 1 docx
... armadillo: roles for wingless signal and zeste-white 3 kinase. Dev. Biol. 166, 54 3 55 6. 86. Rubinfeld, B., Albert, I., and Porfiri, E. (1996) Binding of GSK-3` to the APC-`-catenin complex and regulation ... homology: classical cadherins type I (e.g., E-, N-, P-, R-cadherin), classical cadherins type II (cadherin-6 to -1 2), cadherins found in desmosomes (desmocollins, desmoglei...
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Biochemical, Genetic, and Molecular Interactions in Development - part 6 docx
... 137, 354 4– 354 9. 102. Kurihara, N. and Roodman, G. D. (1990) Interferons-_ and -a inhibit interleukin-1`-stimulated osteoclast-like cell formation in long-term human marrow cultures. J. Interferon ... osteogenesis in preclinical and clinical contexts (1,11–16). Naturally-derived BMPs/OPs and recombinant human osteogenic protein-1 (hOP-1), also known as BMP-7, induce osteo- genes...
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Biochemical, Genetic, and Molecular Interactions in Development - part 7 docx
... changes in bone modeling and remodeling in response to loading and unloading are initiated by an internal mechanostat that is able to sense strain. In this view, changes in bone remodeling occur in response ... 133 65 13371. 80. Klein-Nulend, J., Burger, E. H., Semeins, C. M., Raisz, L. G., and Pilbeam, C. C. (1997) Pulsating fluid flow stimu- lates prostaglandin release and...
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Biochemical, Genetic, and Molecular Interactions in Development - part 2 potx
... CREB/ATF and AP-1 family (52 54 ). Not surprisingly, many promoters of the TGF-`-regulated genes contain either AP-1 sites, such as the PAI-1 (55 ), TIMP-1 (56 ), TGF-`ß1 (57 ), c-Jun (58 ), and _2(I) ... physical and biochemical changes, including a 5- to 10-fold increase in volume and expression of alkaline phos- phatase, type X collagen, and MMP-13 (1,2). Type X collagen is a...
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Biochemical, Genetic, and Molecular Interactions in Development - part 3 pdf
... prolyl 4-hydroxylase, prolyl 3-hydroxylase, and lysyl hydrox- ylase, catalyze the formation of 4-hydroxyproline, 3-hydroxyproline, and hydroxylysine residues in -X-Pro-Gly, -Pro-4Hyp-Gly-, and -X-Lys-Gly- ... chains, called _ chains, and contain at least one unique triple-helical domain with repeating -Gly-X-Y- sequences in each of the constituent chains. The presence of glycine,...
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Biochemical, Genetic, and Molecular Interactions in Development - part 4 ppt
... pseudoreceptor by intercalating in the TGF-` complex and disrupting receptor signaling, thus func- tioning as a naturally occurring dominant mutant of BMP signaling. Tkv In the developing wing disk of ... with Xwnt-8, showing a direct interaction between Frzb and Wnts (84), and Frzb blocks the axis-inducing activity of Xwnt-8 and mouse Wnt-1 when coinjected on the ven- tral side o...
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Biochemical, Genetic, and Molecular Interactions in Development - part 8 pps
... PGE 2 -induced cAMP and inositol trisphosphate accumulation ( 254 ) and cal- cium influx ( 255 ), PGF 2 _-induced PGE 2 synthesis ( 256 ), and PGF 2 _ or PGE 1 - induced interleukin-6 synthesis ( 257 ). As ... the pro- duction of insulin-like growth factor-binding proteins-2, -3 and -4 in human bone marrow stromal cells. Eur. J. Endo- crinol. 144, 54 9 55 7. 1 75. Schmid...
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Biochemical, Genetic, and Molecular Interactions in Development - part 9 potx
... crest were assessed at 9 .5 13 .5 dpc by using molecular markers. A retinoic acid-responsive transcription factor, Ap-2, (42) and cellular retinoic acid-binding protein-1 Fig. 5. Analysis of the endogenous ... Standard developmental toxicity bioassays in rodents include a detailed examination of the near-term fetal skeleton in single-stained (alizarin red for ossified bone) or doubl...
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Biochemical, Genetic, and Molecular Interactions in Development - part 10 doc
... factor regulation, interferon-a, 203, 204 interleukin-1, 202 interleukin-4, 202 interleukin-6, 202, 203 interleukin-11, 203 macrophage colony-stimulating factor, 200, 201 osteoprotegerin, 201 RANKL, 200 transforming ... loss in aging, 253 – 255 connectivity density, 255 mechanical properties, 256 – 258 micro-computed tomography scan data, 251 – 253 model requirements, 251 morphological...
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