Biochemical, Genetic, and Molecular Interactions in Development - part 4 ppt

... form of Hh lacking the cholesterol modification, which retains full signaling activity both in vitro and in vivo (41 ,44 ) and binds to Ptc with similar affinity as does Hh-Np (45 ). In Drosophila, ... with Xwnt-8, showing a direct interaction between Frzb and Wnts ( 84) , and Frzb blocks the axis-inducing activity of Xwnt-8 and mouse Wnt-1 when coinjected on the ven- tral sid...

Ngày tải lên: 11/08/2014, 17:20

... TCF-responsive promoters (103). LEF-1 and TCF-1 have been identified in developing mouse limb bud mesenchymal cells and in tail prevertebrae (1 04) and are induced by BMP -4 during murine tooth and ... significant inhibition of cellular condensation and chondrogenesis in vitro and in vivo using a function-blocking monoclonal antibody, NCD-2, directed against N-cadherin (4...

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... Rosier, R., and O’Keefe, R. (2000) Smad2 and 3 mediate transform- ing growth factor-beta1-induced inhibition of chondrocyte maturation. Endocrinology 141 , 47 28 47 35. 52. Xing, J., Ginty, D., and Greenberg, ... response element binding protein. Proc. Natl. Acad. Sci. USA 95, 44 81 44 86. 45 . Ahn, S., Olive, M., Aggarwal, S., Krylov, D., Ginty, D. D., and Vinson, C. (1998) A domi...

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... prolyl 4- hydroxylase, prolyl 3-hydroxylase, and lysyl hydrox- ylase, catalyze the formation of 4- hydroxyproline, 3-hydroxyproline, and hydroxylysine residues in -X-Pro-Gly, -Pro-4Hyp-Gly-, and -X-Lys-Gly- ... chains, called _ chains, and contain at least one unique triple-helical domain with repeating -Gly-X-Y- sequences in each of the constituent chains. The presence of glyci...

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... Triiodothyronine (T3) stimu- lates insulin-like growth factor (IGF )-1 and IGF binding protein (IGFBP )-2 production by rat osteoblasts in vitro. Acta Endocrinol. (Copenh.) 126, 46 7 47 3. 44 . Pfeilschifter, ... to identify BMP-induced genes. Osx is a novel zinc finger-containing transcrip- tion factor that is specifically expressed in developing bones. Osx contains a proline- a...

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... 137, 3 544 –3 549 . 102. Kurihara, N. and Roodman, G. D. (1990) Interferons-_ and -a inhibit interleukin-1`-stimulated osteoclast-like cell formation in long-term human marrow cultures. J. Interferon ... osteoclastogenesis and RANK expression by TGE-beta1. J. Cell Biochem. 4, 1 041 –1 049 . 100. Gowen, M. and Mundy, G. R. (1986) Actions of recombinant interleukin-1, interleukin-2,...

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... junction-mediated intercellular communication between osteocyte-like MLO-Y4 cells in response to mechanical strain. Endocrinology 142 , 346 4– 347 3. Microgravity and Bone Cells 267 because loading induces ... changes in bone modeling and remodeling in response to loading and unloading are initiated by an internal mechanostat that is able to sense strain. In this view, changes...

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... Baylink, D. J. and Linkhart, T. A. (1993) 1,2 5- Dihydroxyvitamin D3 increases secretion of insulin-like growth factor binding protein -4 (IGFBP -4 ) by human osteo- blast-like cells in vitro and ... the pro- duction of insulin-like growth factor-binding proteins-2, -3 and -4 in human bone marrow stromal cells. Eur. J. Endo- crinol. 144 , 549 –557. 175. Schmid, C., Schlapfe...

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... dpc by using molecular markers. A retinoic acid-responsive transcription factor, Ap-2, (42 ) and cellular retinoic acid-binding protein-1 Fig. 5. Analysis of the endogenous levels of retinoic acid ... Standard developmental toxicity bioassays in rodents include a detailed examination of the near-term fetal skeleton in single-stained (alizarin red for ossified bone) or double-stained (...

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... factor regulation, interferon-a, 203, 2 04 interleukin-1, 202 interleukin -4 , 202 interleukin-6, 202, 203 interleukin-11, 203 macrophage colony-stimulating factor, 200, 201 osteoprotegerin, 201 RANKL, 200 transforming ... 229 negative regulation effectors of cartilage growth, FGF-2, 242 overview, 240 , 241 retinoic acid, 242 , 244 , 246 transforming growth factor-`1, 244 , 246 organ cul...

Ngày tải lên: 11/08/2014, 17:20