Biochemical, Genetic, and Molecular Interactions in Development - part 3 pdf
Biochemical, Genetic, and Molecular Interactions in Development - part 3 pdf
... prolyl 4-hydroxylase, prolyl 3- hydroxylase, and lysyl hydrox- ylase, catalyze the formation of 4-hydroxyproline, 3- hydroxyproline, and hydroxylysine residues in -X-Pro-Gly, -Pro-4Hyp-Gly-, and -X-Lys-Gly- ... without leaving the lumen of cisternae. Cell 95, 9 93 10 23. Regulation of BMP, Wnt, and Hh Signaling 1 13 1 13 From: The Skeleton: Biochemical, Genetic, and Mole...
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Biochemical, Genetic, and Molecular Interactions in Development - part 1 docx
... Wnt ligand binding, glycogen synthase kinase 3` (GSK -3 ` ) is inactivated by a series of kinases and `-catenin (`-cat) accumulates in the cytoplasm and translocates into the nucleus, where it interacts ... at tis- sue and somite boundaries. Development 120, 36 67 36 79. 102. Novak, A., Shu, C., and Chungyee, L. (1998) Cell adhesion and the integrin-linked kinase regulate the...
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Biochemical, Genetic, and Molecular Interactions in Development - part 2 potx
... Smad3 and ATF-2 contribute to TGF-`-mediated effects on chon- drocyte differentiation, and both participate in the induction of PTHrP in chondrocytes (36 ). TGF-` is capable of phosphorylating and ... determines different BMP-2 signaling pathways. J. Biol. Chem. 277, 533 0– 533 8. 35 . Knaus, P. and Sebald, W. (2001) Cooperativity of binding epitopes and receptor chains in th...
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Biochemical, Genetic, and Molecular Interactions in Development - part 4 ppt
... pseudoreceptor by intercalating in the TGF-` complex and disrupting receptor signaling, thus func- tioning as a naturally occurring dominant mutant of BMP signaling. Tkv In the developing wing disk of ... with Xwnt-8, showing a direct interaction between Frzb and Wnts (84), and Frzb blocks the axis-inducing activity of Xwnt-8 and mouse Wnt-1 when coinjected on the ven- tral side o...
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Biochemical, Genetic, and Molecular Interactions in Development - part 5 docx
... to identify BMP-induced genes. Osx is a novel zinc finger-containing transcrip- tion factor that is specifically expressed in developing bones. Osx contains a proline- and serine-rich transcription ... cytochrome c into the cytosol. Subsequently, BMP-2 increased caspase-9 and caspase -3 , -6 , and -7 activity. Inhibition of caspase-9 activity suppressed BMP-2-induced apoptosis....
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Biochemical, Genetic, and Molecular Interactions in Development - part 6 docx
... osteogenesis in preclinical and clinical contexts (1,11–16). Naturally-derived BMPs/OPs and recombinant human osteogenic protein-1 (hOP-1), also known as BMP-7, induce osteo- genesis in nonhuman and human ... depending on the experimental design, can (1) main- tain the integrity of the anlagen and the inherent cell and tissue interactions involved in its normal development,...
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Biochemical, Genetic, and Molecular Interactions in Development - part 7 docx
... 276, 133 65– 133 71. 80. Klein-Nulend, J., Burger, E. H., Semeins, C. M., Raisz, L. G., and Pilbeam, C. C. (1997) Pulsating fluid flow stimu- lates prostaglandin release and inducible prostaglandin ... changes in bone modeling and remodeling in response to loading and unloading are initiated by an internal mechanostat that is able to sense strain. In this view, changes in bone...
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Biochemical, Genetic, and Molecular Interactions in Development - part 8 pps
... factors in fracture healing. Clin. Orthop. 35 5(Suppl.), S301–S3 13. 164. Rosen, C. J. (1999) Serum insulin-like growth factors and insulin-like growth factor-binding proteins: clinical implica- tions. ... Baylink, D. J. and Linkhart, T. A. (19 93) 1,2 5- Dihydroxyvitamin D3 increases secretion of insulin-like growth factor binding protein-4 (IGFBP-4) by human osteo- blast-like cel...
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Biochemical, Genetic, and Molecular Interactions in Development - part 9 potx
... 9.5– 13. 5 dpc by using molecular markers. A retinoic acid-responsive transcription factor, Ap-2, (42) and cellular retinoic acid-binding protein-1 Fig. 5. Analysis of the endogenous levels of retinoic ... Standard developmental toxicity bioassays in rodents include a detailed examination of the near-term fetal skeleton in single-stained (alizarin red for ossified bone) or double-stai...
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Biochemical, Genetic, and Molecular Interactions in Development - part 10 doc
... synthesis induction, 31 1 differentiation role, 30 8, 30 9 insulin-like growth factor-I, 31 4, 31 5 matrix Gla protein, 31 2 mineralization stimulation, 30 9, 31 0 osteocalcin, 31 1, 31 2 osteonectin, 31 3 osteopontin, ... 31 3 osteopontin, 31 2, 31 3 plasminogen, 31 3, 31 4 proliferation inhibition, 31 0, 31 1 prostaglandins, 31 4 table of regulated genes, 31 6 transformi...
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