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Báo cáo y học: " Evidence for genetic association of RORB with bipolar disorder" pptx

Báo cáo y học:

Báo cáo y học: " Evidence for genetic association of RORB with bipolar disorder" pptx

... Medical University, Syracuse, NY, USA, 4Laboratory of Neurophenomics, Department of Psychiatry, Indiana University School of Medicine, Indianapolis, IN, USA, 5Department of Psychiatry, UC San Diego, ... susceptibility variants for bipolar disorder, it is possible they do so by altering theexpression of one or both of the RORB isoforms. One of thehaplotype blocks exhibiting a positive association (block ... Fur-ther evidence for family -genetic risk factors in attention def-icit hyperactivity disorder. Patterns of comorbidity inprobands and relatives in psychiatrically and pediatricallyreferred...
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Báo cáo Y học: Evidence for general stabilization of mRNAs in response to UV light pdf

Báo cáo Y học: Evidence for general stabilization of mRNAs in response to UV light pdf

... lM) as indicated. Cytoplasmic lysates were assayed for GFP-MKK62Eprotein by Western blot,and for activation of the p38 MAP kinase/MK2 pathway by in vitro kinase assays with recombinant HSP27 ... range of different mRNAs without apparent selectivity. Most no-tably, UV light stabilized mRNAs with a 3¢-UTR that didnot contain an ARE, a type of cis-element involved in thecontrol of many cytokine ... indirect association of HuR with those transcripts. Alternatively,HuR may affect only the fate of a subset (i.e. ARE-containing) of mRNAs in response to UV light. Of note,activation of the p38...
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Báo cáo y học: "Testing for the association of the KIAA1109/Tenr/IL2/IL21 gene region with rheumatoid arthritis in a European family-based study" ppt

... rs4492018 and rs1398553 polymorphisms using theTaqMan Allelic discrimination assay (Applied Biosystems). The genetic association analyses for eachSNP and haplotype were performed using the Transmission ... Kelly JA, Adler AJ, Aberle T, Kilpatrick J,Wakeland EK, Li QZ, Wandstrat AE, Karp DR, James JA, Merrill JT,Lipsky P, Harley JB: Genetic association of interleukin-21 poly-morphisms with systemic ... http://arthritis-research.com/content/11/2/R45Page 4 of 7(page number not for citation purposes)analysis of the rs4505848 (A/G) SNP showed an associa-tion of the heterozygous AG genotype with RA (P = 0.04,OR = 1.32,...
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Báo cáo y học: "Increased lymphangiogenesis in joints of mice with inflammatory arthritis" pptx

... and size of synovial lym-phatic vessels compared with their WT littermates. Further-more, the severity of erosive synovitis correlates with thelymphatic drainage capacity to local lymph nodes. ... to all of the data in the study and takes responsibility for the integrity of the data and the accuracy of the data anal-ysis. QZ and STP participated in study design; acquisition,analysis, ... size of LYVE-1+ lymphatic vessels were measured withinthe synovial tissue. The size and area of lymphatic vesselswere expressed per square millimeter of synovium.Electrophoretic mobility shift...
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Báo cáo y học: " Adjunctive long-acting risperidone in patients with bipolar disorder who relapse frequently and have active mood symptoms" doc

... hatthetolerabilityprofilemaybeindependentofmoodstate or severity of symptoms. The mean weight of sub-jects increased by approximately 2 kg, whether mea-sured at study end point or at completion of all 16weeks of ... antipsychotics may allowclinicians to identify and respond more easily to pooradherence [13]. One long-te rm, prospective study of acutelymanic inpatients with bipolar disorder and a history of poor ... 1). Of the subjects with current depressive symp-toms, 81.4% were diagnosed with bipolar type I disor-der, as were 93.2% of subjects with manic/mixedsymptoms. A higher per centage of symptomatic...
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Báo cáo y học: "Evidence for early disease-modifying drugs in rheumatoid arthritis" pps

... with combination therapy at 2 years. Subsequent analysesfound that delaying DMARD therapy by only a few monthsdecreased the ability of the monotherapy to induce remis-sion [20]. The benefits of combination ... a 9-month RCT of hydrox-ychloroquine versus placebo in early RA. Three years afterthe study ended, early DMARD therapy still resulted inless pain and disability.The report by Verstappen and ... strong support for early DMARD therapy. Neverthe-less, the benefits of early DMARDs became less obvious with time. By 5 years patients receiving early DMARDshad similar disease activity and comparable...
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Báo cáo y học: "Evidence for chronic, peripheral activation of neutrophils in polyarticular juvenile rheumatoid arthritis" pdf

... putative patho-genic pathways identified, suggesting that inhibition of neu-trophil activity may provide a useful means of limiting keyaspects of the pathology of polyarticular JRA. Genes down-regulated ... correlationcoefficiency was displayed in a colour mosaic.Polymerase chain reaction validation of array dataSix down randomly selected genes in the patients with polyar-ticular JRA and controls were selected for ... appropriate controls for geneexpression studies in children with polyarticular JRA becausegene expression profiles of peripheral blood buffy coats of children with polyarticular JRA revert...
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Báo cáo y học: " Evidence for natural antisense transcript-mediated inhibition of microRNA function" ppsx

... associated with Tourette's syndrome [35]. Synony-mous mutations in regulatory regions of mRNAs couldcreate or destroy a putative miRNA binding site, there-fore changing the protein output of ... variety of stressresponses [42,43]. A synergy between these two classes of ncRNAs as we have hypothesized here is an intriguingpossibility that would significantly increase the regula-tory power ... power of these families of ncRNAs within the con-text of a larger ncRNA sensory and regulatory network[44]. These mechanisms, together with the unusual butspecific response of the BACE1 system...
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Báo cáo y học: " support for multiple classes of local expression clusters in Drosophila melanogaster, but no evidence for gene order conservation" pot

... clusters.Finally, we ask whether the three cluster types areunits of evolution, in th e sense that they are domains of preserved synteny, as observed in yeast [8-11]. Consid-eration of rates of synteny ... 15% of gene order conservation [19], as reuse of linkagebreakpoints is influenced by the fragility of certain types of sequence (see, for example, [51,52]). We start byexamin ing the role of ... previouslydescribed larger SR co-expression clusters, not yetdescribed in yeast, are likely an artifact of imposing a fixedwindow size and the presence of the type 1 clusters thatfall entirely within...
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Báo cáo khoa học: Evidence for the presence of ferritin in plant mitochondria pdf

Báo cáo khoa học: Evidence for the presence of ferritin in plant mitochondria pdf

... enzyme for tonoplast; oligomycin-sensitive,marker enzyme for mitochondria) were assayed as previ-ously described [18]. Latent IDPase (marker enzyme for Golgi), antimyc in A-insensitive cytochrome ... described for pea stem PMt [17].Enzyme assayATPase activities (vanadate-sensitive, marker enzyme for plasma membrane; molybdate-sensitive, marker enzyme for cytosolic soluble phosphatases; bafilomycin ... lgÆmL)1trypsinfor30minat25°C and stopped by theaddition of 1 mMPMSF. (B) Imm unoblotting of PMt (25 lg) andMpl (25 lg) with monoclonal antibody raised against cytochromec (Cyt c), polyclonal...
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