Báo cáo y học: " Effect of the G72 (DAOA) putative risk haplotype on cognitive functions in healthy subjects" pot

... with impairments in this domain [2,3,5,6]. In the present study we further investigated how genetic alterations in G72 influence cognitive functions in healthy individuals. We examined whether the positive influence of ... [44,45]. The mechanism of G72 might therefore be explained by the following hypothesis: G72 has a modulatory influence on brain activity...

Ngày tải lên: 11/08/2014, 17:20

... antibodies in the SmD peptide ELISA [32]. In the present study we confirmed the dsDNA binding property of the SmD1 peptide. This finding was further supported by the inhibition of dsDNA binding of human ... in 5–30% of patients with SLE, and this frequency varies depending on the detection system, the selection criteria for study cohorts and the ethnicity of...

Ngày tải lên: 09/08/2014, 10:20

... elec- trocardiography showed no evidence of myocardial infarction. The patient’s diabetes was poorly controlled, with neutral protamine Hagedorn insulin measurement s of 40 IU in the morning and 15 IU in the ... develop- ment of his lesions. Having acknowledged these limitations, we think that this case report adds to the increasing evidence in sup- port of a key role fo...

Ngày tải lên: 11/08/2014, 00:23

... to the LPS-binding protein) is the primordial step leading to cytokines secretion, via the NFkappaB pathway. So, the anti-inflammatory effect of SR141716A could be explained by its binding ... human obesity are, in the end, a summation of all of these effects. Interestingly, in rodents, the amelioration of glucose intolerance and insulin resistance observed foll...

Ngày tải lên: 11/08/2014, 03:20

... From the plot of the equilibrium binding responses as a function of the concentrations of the proteins, the K D value was determined using steady state affinity program of biaevaluation software ... the protein without seriously affecting the substrate binding affinity. Binding analyses using BIAcore system To examine whether the mutation of Gly10 to Leu or Pro affects...

Ngày tải lên: 17/03/2014, 17:20

... previous study using the rab- bit anular puncture model, the injection of osteogenic protein- 1 into the NP induced an increased proteoglycan content of both the AF and the NP and the recovery of disc-height ... degeneration of the NP than that in the AF. In addition, the direct injection of siRNA into the NP may induce a localized improvement. It is worth no...

Ngày tải lên: 09/08/2014, 14:22

... clotting of the secondary circuit in a second patient, and an episode of hypotension at the start of the procedure in a third patient. Discussion The current concept of the pathogenesis of circulatory ... meas- ured in the albumin dialysate of both the MARS and Prometh- eus devices. Determination of the concentration of vasopressin in the dialysate wa...

Ngày tải lên: 13/08/2014, 01:20

... orientation in the myosin head than the widely used maleimide spin label [26]. Selective modification of Cys707 strongly affects MgATP hydrolysis, and the motor function of myosin heads in the in vitro ... binding to actin. Accordingly, our experiments support the view that the rotational motion of myosin reflects functionally relevant conformational changes during ATP h...

Ngày tải lên: 24/03/2014, 03:21

... by synovial lining hyperplasia and sublining infil- tration of inflammatory cells [1]. Fibroblast-like synoviocytes (FLSs) play a crucial role in joint damage as well as the prop- agation of inflammation ... 5 Regulation of AP-1 binding and transcriptional activity is TAK1-depend-entRegulation of AP-1 binding and transcriptional activity is TAK1-depend- ent. The effect of TA...

Ngày tải lên: 09/08/2014, 10:20

... without leaving traces of their involvement in the lateral transfer. In both intron-homing a nd intronless-homing the primary role of the homing endonuclease is to intro- duce a dsDNA break in the genome ... ion by the DNA modifications in their vicinity or through evolutionary adjustments in the expression of phage genes that control the susceptibility of phag...

Ngày tải lên: 12/08/2014, 02:20