Báo cáo y học: "A randomized, double-blind, placebo-controlled trial to assess the efficacy of topiramate in the treatment of post-traumatic stress disorder" pot

... Our primary end point is the change of anxiety and worry score (Beck Anxiety Inventory and Penn State Worry Scale) from baseline to the end of intervention. For primary analyses, treatment ... participated in the drafting of the protocol for the intervention. WWSL participated in the coordination, as well as the revision of the manuscript. She also partici...

Ngày tải lên: 11/08/2014, 16:21

... not vary in relation to the number of cycles of chemotherapy given, (6 vs. 9 cycles of PAC [Platinum-Adriamycin-Cyclophosphamide] [19], 5 vs. 10 cycles of polychemotherapy with Cisplatin [20], ... our study with the exception of 1 case of grade 4 thrombocytopenia. Oddly, there were more relapses in lumboaortic-inguinal lymph nodes in the chemotherapy arm, however...

Ngày tải lên: 03/11/2012, 09:57

... fever. Efficacy The primary efficacy end point of the study was the ACR 20 response at the completion of the 24-week study (Table 3). In the intention -to- treat (ITT) responder-at-end- point analysis, ... irrespective of study completion status. Discussion The goal of this study was to assess the effects of IFN-β- 1a in the treatment of RA. The d...

Ngày tải lên: 09/08/2014, 01:23

... maker working in an organization sup- portive of evidence-informed decision making, leads to outcomes in the hypothesized direction. In addition, sim- ply having access to an online registry of research ... findings that policy-makers were more likely to use the results of technology assessments when they requested information, and when they received the infor- mation...

Ngày tải lên: 11/08/2014, 05:21

... were used to calculate the number of days they participated. At the end of the training participants were asked 13 questions, how they liked the training, whether they were able to use the techniques ... those reported in the manuals of the instruments (Table 2). General distress. The global score (GSI) of the German Brief Symptom Inventory (BSI) [26], t...

Ngày tải lên: 11/08/2014, 16:20

... compare the efficacy of topiramate with pla- cebo in the treatment of PTSD, and will study its tolerabil- ity through the drop out rate in each group. The primary hypothesis is that topiramate ... superior to placebo in the treatment of PTSD. Secondary research goals includes studying the efficacy of topiramate in social adjustment, functioning and...

Ngày tải lên: 11/08/2014, 17:20

... study. Endpoints The primary endpoint in Part A of the study was the safety of AMG 108; additional endpoints included the PK of AMG 108. In Part B, the primary endpoint was the clinical efficacy ... efficacy of AMG 108 (change from baseline to week 6 in the WOMAC pain score); additional endpoints included the safety and PK of AMG 108. Safety endpo...

Ngày tải lên: 12/08/2014, 17:22

... demonstrated activity with estramustine-based combinations and the activity of combined navelbine and mitoxantrone, sup- porting the testing of combination therapy with estra- mustine, mitoxantrone, and vinorelbine ... at the beginning of each cycle. Conditions for dose modification in the case of toxicity were specified in the protocol. Efficacy and Safety Response an...

Ngày tải lên: 18/06/2014, 16:20

... Increased Following the 12 week trial, 15 of 17 patients opted to continue Apatone therapy. Any decision to remain on Apatone therapy was left entirely to the patient. Anecdotally, most patients ... organs. 9 The purpose of this study was to evaluate the safety and efficacy of oral Apatone administered throughout the day in prostate cancer in patients...

Ngày tải lên: 08/08/2014, 17:20

... documented a series of delays, coupled with a lack of access to information and support at key points in the care continuum. Several broad themes emerged in a nalysis. These are g rouped in the sequenc ... registering upwards of 50% [20]. Nurses interviewed spoke of the challenge of attracting and retaining health personnel in the Eastern Cape, especially in cert...

Ngày tải lên: 10/08/2014, 05:22