báo cáo khoa học: " Ethical issues in implementation research: a discussion of the problems in achieving informed consent" ppt

... CentralPage 1 of 8(page number not for citation purposes) Implementation ScienceOpen AccessDebate Ethical issues in implementation research: a discussion of the problems in achieving informed ... phe-nomenon. In a randomised trial of 'opt -in& apos; versus 'opt-out' strategies for an observational study of angina thatrequired clinic attendance, response was defined asattendance at ... to an inter-vention and collect data from individuals within thatsocial unit. In implementation research, a cluster may bedefined as an individual health care professional, a familypractice,...

Ethical issues in implementation research: a discussion of the problems in achieving informed consent pptx

... within thatsocial unit. In implementation research, a cluster may bedefined as an individual health care professional, a familypractice, a hospital department, or a hospital, and data arecommonly ... phe-nomenon. In a randomised trial of 'opt -in& apos; versus 'opt-out' strategies for an observational study of angina thatrequired clinic attendance, response was defined asattendance at ... consideration of the ownership of information, and rights of accessto and exploitation of data is required. For health care professionals and organizations, there is a balance between clinical freedom...

Báo cáo khoa học: Two separate regions essential for nuclear import of the hnRNP D nucleocytoplasmic shuttling sequence ppt

... common to all D isoforms.Mutational analysis of DNS indicated that two separ-ate regions in DNS, the N-terminal seven amino acidsand the two C-terminal amino acids, are essential fornuclear import ... Nakashima K, Hagiwara T & Yamada M (2002)Nuclear localization of peptidylarginine deiminase Vand histone deimination in granulocytes. J Biol Chem277, 49562–49568.44 Adam SA, Marr RS & ... either of the last two C-terminal amino acids PYcompletely abolished the in vivo and in vitro nuclearimport activity as well as the binding to Trn-1. Ala-nine scanning mutagenesis of the sequence...

báo cáo khoa học: " Ethical issues raised by common copy number variants and single nucleotide polymorphisms of certain and uncertain significance in general medical practice" potx

... question of whether the physician or patient should have the ability to obtain a second opinion regarding the interpretation of the data. One attractive option would be to have a group of professionals ... Should the information be withheld by the laboratory or the physician because the genotype is of uncertain signiﬁcance? It may be preferable to explain the ﬁndings and all the uncertainties and ... regulation of laboratories and testing. Is it ethical, legal, or desirable to allow gene patents that can limit the availability of testing or increase the cost? Policies related to diagnostic...

Tài liệu Báo cáo khoa học: Neuronal growth-inhibitory factor (metallothionein-3): evaluation of the biological function of growth-inhibitory factor in the injured and neurodegenerative brain pdf

... GIF, in 1991, sparked considerable interest in understanding the role of all MTs in the brain, and particularlywithin the injured or diseased brain. In the case of GIF, the protein has many neuroprotective ... Kohmura E, Sakaki T, Nonaka M,Yamada K, Yamashita T, Kishiguchi T, Sakaguchi T &Hayakawa T (1997) Expression of growth inhibitoryfactor mRNA after focal ischemia in rat brain. J CerebBlood ... within the brain. Furthermore, the discovery and continued investigation of this brain-spe-ciﬁc MT isoform has led to intense interest in the roles of the entire MT family in the brain, with particularfocus...

Báo cáo khoa học: Increased NADPH concentration obtained by metabolic engineering of the pentose phosphate pathway in Aspergillus niger docx

... However, the position of the samples in Fig. 4A is in uenced by the level of all variables in these samples. For example, the samples of the strains in the third quadrant of Fig. 4A have a tendency ... in the two PCs. The variables in the thirdquadrant are all negatively correlated to NADPH in the two PCs. The variables in the fourth quadrant aremainly positively correlated to NADPH, because ... concentration of NADP and NAD had a tendency to be increased in Gnd20, which might counterbalance the regulatoryeffect of the high NADPH concentration. The lack of a signiﬁcant increase in NADH parallel...

Báo cáo khoa học: Apoptosis and autophagy: BIM as a mediator of tumour cell death in response to oncogene-targeted therapeutics pptx

... oncoprotein [56]. The mutant BCR–ABL tyro-sine kinase activates several signalling pathways, includ-ing the ERK1 ⁄ 2 pathway, the PKB pathway and the Janus kinase ⁄ signal transducer and activator of ... Journal compilation ª 2009 FEBSproviding a rationale for the use of combinations of MEK1 ⁄ 2 inhibitors and PI3K–PKB pathway inhibitors.Indeed, rapamycin, an inhibitor of mammalian target of rapamycin ... control; in all casesinhibition of the oncogenic kinase results in the loss of downstream survival signalling pathways and a consequent increase in the expres-sion of BIM. Inactivation of the ERK1...

Báo cáo khoa học: Expression, localization and potential physiological signiﬁcance of alcohol dehydrogenase in the gastrointestinal tract pdf

... throughout the gastrointestinal tract and providenew data to understand the physiological role of ADHclasses in the gastrointestinal tract and the etiopathogenyrelated to alcohol abuse.Experimental ... alcoholpathology. Localization of ADH, acting as retinol dehydro-genase/retinal reductase, also indicates sites of active retinoidmetabolism in the gut, essential for mucosa function andvitamin A ... Localization of ADH1 and ADH4 in jejunum and ileum. ADH1 (A) and ADH4 (B) mRNA detection in jejunal mucosa. Immunodetection of ADH4 protein in ileal mucosa (C). Omission of anti-ADH4 IgG in an adjacent...

Báo cáo khoa học: "Left costocervical vein malformation with anomalous ramification of aortic arch in a dog" doc

... laterally to the leftsubclavian artery and terminates in the dorsolateral surface of the cranial part of the cranial vena cava or of the brachiocephalic vein [8]. In the present study, it was ... dog cadaver in the dissecting room at the College of Veterinary Medicine, Seoul National University.Anomalies in the great vessels and of the heart are of interest from the surgical point of view, ... those of the left subclavian artery.Abnormal termination of the left costocervical vein wasalso observed in this animal. The vein passedcaudoventrally over the aortic arch and entered the leftventricle...

Báo cáo khoa học: "Intraabdominal and retroperitoneal soft-tissue sarcomas - outcome of surgical treatment in primary and recurrent tumors" potx

... histopathological types of sarcoma have been described [7,8].Diagnosing intraabdominal and retroperitoneal sarco-mas(IaRS)isoftendifficultsincethesignsandsymptoms are o ften discreet and uncharacteristic. ... resection of adjacent organs wasnecessary in 48%, which is in the same order of magni-tude as in other reports [7], and radical surgery wa sachieved in 78%, also comparable to other centers [7]. Asexpected, ... million inhabi-tants. During this period, all peripheral surgical depart-ments in the area began referring sarcoma patients to the center for diagnosis, evaluation, and surgery.Data on primary and...

Xem thêm