báo cáo khoa học: " The role of economics in the QUERI program: QUERI Series" ppt

Báo cáo khoa học: Dual role of Nbs1 in the ataxia telangiectasia mutateddependent DNA damage response ppt

... formation of MRNfoci [19–21]. The Mre11-binding domain of human Nbs1 hasbeen localized to amino acids 682–693 in the COOH-terminal region of the protein. Deletion of this region of Nbs1 results in ... damage, thereby promotingATM-dependent signaling [23]. Domains similar to the ATM-binding domain of Nbs1 are also found in ATRIP and Ku80 and are required for the interaction of these proteins with ... an NH2-terminally truncatedNbs1 protein that contains an intact Mre11-bindingdomain. Differences in the nature of the Nbs1 muta-tion, as well as in the dose of radiation administeredto...

Tài liệu Báo cáo khoa học: Single phosphorylation of Tyr304 in the cytoplasmic tail of ephrin B2 confers high-afﬁnity and bifunctional binding to both the SH2 domain of Grb4 and the PDZ domain of the PDZ-RGS3 protein ppt

... eﬀect of tyrosine phosphorylations on the binding aﬃnity of ephrinB2(301–333) to the SH2 domain of Grb4 and to the PDZdomain of PDZ-RGS3. In the combination experiments, the two Cterminal tyrosine ... detect the binding interactions between the peptides and the Grb4 SH2 domain. The afﬁnity of the binding interactions was evaluated by measuring the changes of ﬂuorescence polarization of the peptides ... unknown whether the two classes of eﬀectors can bind to B ephrins simulta-neously or if the binding of one aﬀects the binding of the other. We report here that phosphorylation of Tyr304 in the functional...

Báo cáo khoa học: Lysosomal localization of GLUT8 in the testis – the EXXXLL motif of GLUT8 is sufﬁcient for its intracellular sorting via AP1- and AP2-mediated interaction docx

... resolve some of these discrepancies in order to (a) identify the subcellu-lar localization of GLUT8 in testis, (b) elucidate the role of APs in GLUT8 sorting, and (c) understand the role of the EXXXLL ... with the late endosomal ⁄ lysosomalmarker protein LAMP1, a ﬁnding that is in agreementwith our in vitro binding data.Targeting of GLUT8 in the absence of AP1and AP2 In order to investigate the ... GLUT8NICD to the tailless lumenal domain of the IL-2 receptor alpha chain (TAC)protein (interleukin-2 receptor a chain) targeted the protein to intracellularmembranes, indicating that its N-terminal...

Báo cáo khoa học: "Histochemical Detection of Glycoconjugates in the Male Reproductive System of the Horse" pptx

... tissue of the corpus epididym is. Strong SBA staining w as seen in epithelial cells in the testis, stereocilia of the corpusand cauda epididym is, and in the vas deferens. Therew ere intense ... suggests that in the horse, some lectins are involved in cell degeneration,either as a cause or a consequence. Additionally, the hetero-geneity of the lectin staining patterns in the reproductivetubules ... reproductive system of the horse. The heterogeneity of the lectin stainingpattern in the reproductive tubules of adult horsessuggests that the carbohydrate composition of eachcell type is...

Báo cáo khoa học: "Surgical removal of stones in the stomach of a tiger shovelnose catfish" potx

... transferred to the table,where three tubes for maintaining anesthesia were placed in both mouth and gills. The water with isoflurane used in induction anesthesia was also used in maintaining anesthesiawith ... referredto the veterinary medical teaching hospital of the college of veterinary medicine of Konkuk university, because of suspecting a foreign body in stomach. The catfish had ahistory of anorexia, ... One of those was round, and the otherswere narrow and angled. Round thing looked to be in innerpart in section of swim bladder margin, and the otherslooked to be in outer part in section of...

Báo cáo khoa học: "Increased expression of osteopontin in the spinal cords of Lewis rats with experimental autoimmune neuritis" doc

... µm.Osteopontin in rat spinal cord with EAN 293nerves and spinal roots. These two molecules may beinvolved in cell migration into the spinal cord in the earlystages of EAN. Further study of the functional ... receptor of OPN [2]. It was weakly expressed in the white matter of the normal spinal cord in our previousstudy [13] and in the present study. In rats having spinal cordinfiltrates of inflammatory ... asabundant inflammatory cells in the spinal nerve roots in the same animals [14]. To investigate remote activation of the CNS in peripheral nervous system disease, we focused on the spinal cord in the...

Báo cáo y học: "A role of ygfZ in the Escherichia coli response to plumbagin challenge" pdf

... resolving the threat of plumb agin. One of the likely roles of YgfZ involved is possibly to accelerate the breakdown of plumbagin.Determining the ygfZ-dependent metabolites of plumbaginTo confirm the ... test whether degradation of plumbagin occurs by the bacteria, the amounts of plumbagin remained in the cul-ture media of ΔygfZ and the parental strains wer e com-pared by using chloroform extraction ... extent with the ΔsoxR , ΔsoxS,andΔahpCstrains whereas no effect was seen with the o therstrains. The MICs of the bacteria toward plumbaginwere then determined. The MIC of the parental strainwas...

báo cáo khoa học: " Safe storage of methadone in the home - an audit of the effectiveness of safety information giving" ppt

... in table 3.Only 1 of the standards reached 100% in the sample stud-ied, that being the dispensing of methadone in containerswith child resistant caps.Discussion The accidental ingestion of ... items on children within the home, of whom 95 (60.1%) had children either living in or visiting the home. An assessment by these 95 patients of the risk of children knowing where the methadone wasstored ... purposes)prescribing, provision of measuring devices on requestand the provision of information on the particular risks of methadone to children. The risks to children of unsafe storage of medicines is notof...

báo cáo khoa học: " The role of economics in the QUERI program: QUERI Series" ppt

... important role in QUERI since its inception. Researchers with experience in health economics were engaged in the creation of QUERI in the late 1990s. Annual oversight on the progress andplans of QUERI ... sites. Therefore, we recommend revision of the guide-lines to add cost as a domain of measurement in single-site studies. In the case of using VA informatics innovations toenhance adoption of ... implementationintervention consisted of developing and installing pro-gramming code, and then electronically activating the clinical reminder at each site. Once the initial code wasdeveloped and installed,...

Tài liệu Báo cáo khoa học: A role of miR-27 in the regulation of adipogenesis ppt

... or without hematoxylin staining. In hypoxia experiments, 3T3-L1 cells were maintained in a hypoxia chamber (Invivo 400; Ruskinn Inc., Cincinnati,OH, USA) constantly maintained at 1% O2. Culturemedium ... lgÆmL)1insulin, 1 lm dexamethasone, and0.5 mm IDM). Cells were then maintained in DMEM con-taining 10% fetal bovine serum and 1 lgÆmL)1insulin. The medium was replaced every other day. ... cultured in DMEM containing 10% fetal bovineserum. OP9 cells were grown in aMEM containing 20%fetal bovine serum. C2C12 cells were maintained in DMEMcontaining 10% fetal bovine serum.Adipogenic...

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