... with the synthesis of SPA in A. actinomycetemcomitans SUNYaB 75 (serotype a) con-tains 14 ORFs (Fig. 2A) . A protein database search wasperformed with the programsFASTA[37] and BLASTat the National ... possible that feedback inhibition of the GDP -a- D-mannose 4,6-dehydratase occurs via the GDP-6-deoxy-D-talose pathway in A. actinomycetemcomitansSUNYaB 75. In the enzyme assay using the purifiedHis6-tagged ... Yoshida, Y. , Yamashita, Y. & Koga, T. (1998) A gene cluster for 6-deoxy-L-talan synthesis in Actinobacillusactinomycetemcomitans. Biochim. Biophys. Acta 1442, 409–414.35. Yoshida, Y. , Nakano,...