TOXICOLOGICAL CHEMISTRY AND BIOCHEMISTRY - CHAPTER 10 ppsx

... element? SS Cd H + S H + S H Cd 2+ + C CPO 3 CO H HHO H H O C CPO 3 CO PO 3 HHO H H O O C CPO 3 CO AsO 3 HHO H H O O 2 - 2 - 2 - 2 - 3 - Phosphate Glyceraldehyde 3-phosphate 3 - Arsenite (AsO 3 ) Spontaneous hydrolysis + CC OH H NH 3 C H H O OCC H H ALA ... energy (10. 6.1) Figure 10. 7 Interference of arsenic(III) with ATP production by phosphorylation. C CPO 3 CO H...

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... 1.2. A complete list of the well over 100 known elements which may be found in any Figure 1.2 Atoms of carbon and nitrogen. - - - - - - - - - - An atom of carbon, symbol C. Each C atom ... Cataloging-in-Publication Data Manahan, Stanley E. Toxicological chemistry and biochemistry / by Stanley E. Manahan 3rd ed. p. cm. Includes bibliographic...

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... ||||| ). C N C C C N O O H H H H CH 3 C N C C C N O O H H H N C C C N C N C N H H H NH 2 N C C C N C N C NH H O H 2 N H CC C C CH 2 HO H H HO H OH OH H O CC C C CH 2 HO H H HO H H OH H O P O - O - - O O Occur in both DNA and RNA Uracil (U) Thymine (T) Adenine (A) Guanine(G) Phosphate 2-Deoxy-β-D- ribofuranose C N C C C N NH 2 O HH H H Cytosine (C) β-D-Ribofuranose Occur ... Medic...

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... C O O - CHH C O O - CHH CO - O CC O O - CHH C O O - CH CO - O H HO C C CO - O HH O O - O C HHC Citrate Isocitrate α-Ketoglutarate C C S HH O O - O C HHC CoA CHH O - O C HHC C O O - C O - O C C C O O - H H C O - O C C C O O - H HH OH C O - O C C C O O - O HH Oxaloacetate Malate Fumarate ... with acetyl-CoA from glycolysis to s...

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... represents 2,3,7,8-tetrachlorodibenzodioxin, commonly called “dioxin.” 10 5 10 4 10 3 10 2 10 1 10 - 1 10 - 2 10 - 3 10 - 4 10 - 5 DEHP b Ethanol Sodium chloride Malathion Chlorane Heptachlor Parathion Tetrodotoxin d TCDD e Botulinus ... substances and their metabolites react biochemically in an organism to exert a toxic effect. Chapter 7 is devoted...

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... benzo(a)pyrene 7, 8- diol-9 ,1 0- epoxide. Benzo(a)pyrene {O}, epoxidation O Benzo(a)pyrene 7,8-epoxide + H 2 O, epoxide hydrolase HO HO Benzo(a)pyrene 7,8-diol benzo(a)pyrene 7,8-diol-9 ,1 0- epoxide HO HO O {O}, ... DNA N C N C C C N N CH H O H 2 N N C N C C C N N CH H O H 2 N CH 3 CH 3 Dimethylnitros- 3,3-Dimethyl- 1- 1,2-Dimethylhydra- Methylmethane- ONN CH 3 CH 3 NN HH H 3 CCH 3 CH...

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... facile detection of β -galactosidase activity. This is accomplished with the chromogenic substrate 5-bromo-4-chloro-3-indoyl- β -D-galactopyrano- side, which is metabolized by β -galactosidase to ... Zetterqulist, H., and Olerup, O., HLA-DR, -DQ, and -DP alleles in nickel, chromium and/ or cobalt-sensitive individuals: genomic analysis based on restriction fragment length polymor- phis...

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... of symptoms and severity. These include impairment of judgment and visual perception at CO levels of 10 ppm in air; dizziness, headache, and weariness (100 ppm); loss of consciousness (250 ppm); and ... to cigarette smoke. 10 Long-term exposure to asbestos, alone, increases the incidence of lung cancer about 5-fold, cigarette smoking roughly 1 0- fold, but the two together more t...

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... As OH O OH NO 2 3-Nitro-4-hydroxyphenyl- arsinic acid (Roxarsone) HO As OH O H H CNH 2 O N-carbamoylarsinic acid (Carbarsone) N N N SCH H H As OHHO O H 2-Methylthio- 4-( 2'-phenylarsenic acid )- aminopyrimidine L1618Ch12Frame ... compounds found in seaweed and in sheep feeding on the seaweed. β-D-Ribofuranoside, 2,3-dihydroxypropyl 5-deoxy- 5-( dimethylarsinyl) (an arsenosugar)...

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... CCOH OHH HN HC O CH 3 C C H HH OH C H HH L-Cysteine, N-acetyl-S- [ 1-( hydroxymethyl )-2 -propenyl] mercapturic acid conjugate CSC CCOH OHH HN HC O CH 3 C H H OH HH CC H H L-Cysteine, N-acetyl-S- (2-hydroxy-3-butenyl) mercapturic ... H H H CC C H C H H OHHO O HH HCC 1,2-Epoxybutene-3 Diepoxybutane 3-Butene-1,2-diol 3,4-Epoxy-1,2-butane diol CSC CCOH OHH HN HC O CH 3 C H H H H OH H C HO H...

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