TOXICOLOGICAL CHEMISTRY AND BIOCHEMISTRY - CHAPTER 4 pdf
TOXICOLOGICAL CHEMISTRY AND BIOCHEMISTRY - CHAPTER 4 pdf
... C O O - CHH C O O - CHH CO - O CC O O - CHH C O O - CH CO - O H HO C C CO - O HH O O - O C HHC Citrate Isocitrate α-Ketoglutarate C C S HH O O - O C HHC CoA CHH O - O C HHC C O O - C O - O C C C O O - H H C O - O C C C O O - H HH OH C O - O C C C O O - O HH Oxaloacetate Malate Fumarate ... with acetyl-CoA from glycolysis to s...
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TOXICOLOGICAL CHEMISTRY AND BIOCHEMISTRY - CHAPTER 16 pdf
... quantities as substi- tutes for ozone-depleting chlorofluorocarbons (CFCs). The two most common HCFCs are 1, 1- dichloro-2,2,2-trifluoroethane (HCFC-123) and 1,1-dichloro- 1- uoroethane (HCFC- 141 b): + O 2 OO CC H . . CC H Lipid radical, ... trifluoroacetylchloride: (16.2.6) 1,1-Dichloro-2,2, 2- trifluoroethane (HCFC-123) HC Cl Cl CF F F FC Cl Cl CH H H 1,1-Dichloro- 1- fluoroethan...
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TOXICOLOGICAL CHEMISTRY AND BIOCHEMISTRY - CHAPTER 1 pot
... elements. 2 He 4. 003 4 Be 9.012 7 N 14. 01 8 O 16.00 9 F 19.00 10 Ne 20.18 11 Na 22.99 12 Mg 24. 3 13 Al 26.98 14 Si 28.09 15 P 30.97 16 S 32.07 17 Cl 35 .45 18 Ar 39.95 19 K 39.10 20 Ca 40 .08 21 Sc 44 .96 22 Ti 47 .88 23 V 50. 94 24 Cr 52.00 25 Mn 54. 94 26 Fe 55.85 27 Co 58.93 28 Ni 58.69 29 Cu 63.55 30 Zn 65.39 31 Ga 69.72 32 Ge 72.59 33 As 74. 92 34 Se 78.96 35 Br 79.9...
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TOXICOLOGICAL CHEMISTRY AND BIOCHEMISTRY - CHAPTER 3 pps
... ||||| ). C N C C C N O O H H H H CH 3 C N C C C N O O H H H N C C C N C N C N H H H NH 2 N C C C N C N C NH H O H 2 N H CC C C CH 2 HO H H HO H OH OH H O CC C C CH 2 HO H H HO H H OH H O P O - O - - O O Occur in both DNA and RNA Uracil (U) Thymine (T) Adenine (A) Guanine(G) Phosphate 2-Deoxy-β-D- ribofuranose C N C C C N NH 2 O HH H H Cytosine (C) β-D-Ribofuranose Occur ... phosp...
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TOXICOLOGICAL CHEMISTRY AND BIOCHEMISTRY - CHAPTER 6 pps
... substances and their metabolites react biochemically in an organism to exert a toxic effect. Chapter 7 is devoted to defining and explaining toxicological chemistry, and Chapters 10–19 cover the toxicological ... represents 2,3,7,8-tetrachlorodibenzodioxin, commonly called “dioxin.” 10 5 10 4 10 3 10 2 10 1 10 - 1 10 - 2 10 - 3 10 - 4 10 - 5 DEHP b Ethanol...
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TOXICOLOGICAL CHEMISTRY AND BIOCHEMISTRY - CHAPTER 7 pptx
... benzo(a)pyrene 7, 8- diol-9,10-epoxide. Benzo(a)pyrene {O}, epoxidation O Benzo(a)pyrene 7,8-epoxide + H 2 O, epoxide hydrolase HO HO Benzo(a)pyrene 7,8-diol benzo(a)pyrene 7,8-diol-9,10-epoxide HO HO O {O}, ... 15, pp. 343 –396. 12. Ames, B.N., The detection of environmental mutagens and potential carcinogens, Cancer, 19 84, chap. 53, pp. 20 34 2 040 . QUESTIONS AND PROBLEMS 1. Define...
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TOXICOLOGICAL CHEMISTRY AND BIOCHEMISTRY - CHAPTER 8 doc
... facile detection of β -galactosidase activity. This is accomplished with the chromogenic substrate 5-bromo -4 - chloro-3-indoyl- β -D-galactopyrano- side, which is metabolized by β -galactosidase to ... mutagenicity assay, Mutat. Res., 45 5, 71–80, 2000. 4. Emtestam, L., Zetterqulist, H., and Olerup, O., HLA-DR, -DQ, and -DP alleles in nickel, chromium and/ or cobalt-sensitive indivi...
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TOXICOLOGICAL CHEMISTRY AND BIOCHEMISTRY - CHAPTER 10 ppsx
... phosphorylation. C CPO 3 CO H HHO H H O C CPO 3 CO PO 3 HHO H H O O C CPO 3 CO AsO 3 HHO H H O O 2- 2- 2- 2- 3- Phosphate Glyceraldehyde 3-phosphate Additional processes leading to ATP formation 3- Arsenite (AsO 3 ) 1-arseno- 3- phosophoglycerate Spontaneous ... Toxicology, 3rd ed., Hodgson, E. and Smart, R.C., Eds., Wiley Inter- science, New York, 2001, pp. 45 3 48...
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TOXICOLOGICAL CHEMISTRY AND BIOCHEMISTRY - CHAPTER 11 pot
... with asthma, Occup. Environ. Med., 56, 544 – 547 , 1999. 18. Newhook, R., Meek, M.E., and Walker, M., Carbon disulfide: hazard characterization and exposure- response analysis, Environ. Carcinog. ... human blood and on rodents suggest that ClO 2 and its metabolic product ClO 2 – cause formation of methemoglobin, decrease the activities of glucose-6-phosphate dehydro- genase and glut...
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TOXICOLOGICAL CHEMISTRY AND BIOCHEMISTRY - CHAPTER 12 pps
... As OH O OH NO 2 3-Nitro -4 - hydroxyphenyl- arsinic acid (Roxarsone) HO As OH O H H CNH 2 O N-carbamoylarsinic acid (Carbarsone) N N N SCH H H As OHHO O H 2-Methylthio- 4- ( 2'-phenylarsenic acid )- aminopyrimidine L1618Ch12Frame ... cancer and leukemic cells, is 2- methylthio- 4- ( 2'-phenylarsenic acid)-aminopyrimidine: Organoarsenic compounds are used as animal feed add...
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