TOXICOLOGICAL CHEMISTRY AND BIOCHEMISTRY - CHAPTER 3 pps

... wall Chloroplast Starch grain Mitochondria L1618Ch03Frame Page 60 Tuesday, August 13, 2002 5:54 PM Copyright © 20 03 by CRC Press LLC C HAPTER 3 Biochemistry 3. 1 BIOCHEMISTRY Most people have had the ... phosphate. DNA mol- ecules are made up of the nitrogen-containing bases adenine, guanine, cytosine, and thymine; phosphoric acid (H 3 PO 4 ); and the simple sugar 2-d...

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... death Xenobiotic NCCOCCH H HH H H HO Acetylcholinesterase H 2 O OHNCC H HH H C H HC OH O H (CH 3 ) 3 (CH 3 ) 3 + Acetylcholine + + + L1618Ch06Frame Page 130 Tuesday, August 13, 2002 5:51 PM Copyright © 20 03 by CRC Press LLC 6.12.1 Synergism, Potentiation, and Antagonism The ... substances and their metabolites react biochemically in an organism to exert a toxic effect. Chapter...

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... element? SS Cd H + S H + S H Cd 2+ + C CPO 3 CO H HHO H H O C CPO 3 CO PO 3 HHO H H O O C CPO 3 CO AsO 3 HHO H H O O 2 - 2 - 2 - 2 - 3 - Phosphate Glyceraldehyde 3- phosphate 3 - Arsenite (AsO 3 ) Spontaneous hydrolysis + CC OH H NH 3 C H H O OCC H H ALA ... phosphorylation. C CPO 3 CO H HHO H H O C CPO 3 CO PO 3 HHO H H O O C CPO 3 CO AsO...

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... As OH O OH NO 2 3- Nitro-4-hydroxyphenyl- arsinic acid (Roxarsone) HO As OH O H H CNH 2 O N-carbamoylarsinic acid (Carbarsone) N N N SCH H H As OHHO O H 2-Methylthio- 4-( 2'-phenylarsenic acid )- aminopyrimidine L1618Ch12Frame ... seaweed and in sheep feeding on the seaweed. β-D-Ribofuranoside, 2 , 3- dihydroxypropyl 5-deoxy- 5-( dimethylarsinyl) (an arsenosugar) Arsenobetaine...

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... compounds. OH CH 3 OH CH 3 OH OH CH 3 OH Phenol o-Cresol m-Cresol p-Cresol 2-Naphthol + H 2 O + OH - O - OH L1618Ch14Frame Page 297 Tuesday, August 13, 2002 5: 43 PM Copyright © 20 03 by CRC Press ... ethyl) 1,2 ,3, 4-Diepoxybutane (2,2'-bioxirane) Benzene-1,2-oxide Naphthalene-1,2-oxide O O OH H H OH Benzene trans-1,2-dihydrodiol C HH O Formaldehyde L1618Ch14Frame Pa...

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... purpose are meso -2 , 3- dimer- captosuccinic acid, diethyldimercapto succinate, α -mercapto- β -( 2-furyl), and α -mercapto- β -( 2- thienyl) acrylic acid. 3 The structural ... are only three major ones: trans - 2-butene-1-thiol, trans -2 -butenyl-1-thioacetate, and 3- methyl-1-butanethiol 5 : 17.2.5 Carbon Disulfide and Carbon...

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... Chemistry References Supplementary References Questions and Problems Chapter 3 Biochemistry 3. 1 Biochemistry 3. 1.1 Biomolecules 3. 2 Biochemistry and the Cell 3. 2.1 Major Cell Features 3. 3 ... of environmental chemistry. Chapter 3, Biochemistry, ” gives the fundamentals of the chemistry of life processes essential to understanding toxicological chemistry a...

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... C O O - CHH C O O - CHH CO - O CC O O - CHH C O O - CH CO - O H HO C C CO - O HH O O - O C HHC Citrate Isocitrate α-Ketoglutarate C C S HH O O - O C HHC CoA CHH O - O C HHC C O O - C O - O C C C O O - H H C O - O C C C O O - H HH OH C O - O C C C O O - O HH Oxaloacetate Malate Fumarate ... (ADP): ATP N N C N N NH 2 H CC C C H...

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... DNA N C N C C C N N CH H O H 2 N N C N C C C N N CH H O H 2 N CH 3 CH 3 Dimethylnitros- 3, 3-Dimethyl- 1- 1,2-Dimethylhydra- Methylmethane- ONN CH 3 CH 3 NN HH H 3 CCH 3 CH 3 S O O H 3 CO NNN CH 3 CH 3 amine phenyltriazine zine sulfonate CH H OH N CH 3 NO ONN CH H CH 3 OH CHH O ONN H CH 3 HO -+ NN H CH 3 Other ... sulfonate CH H OH N CH 3 NO ONN CH H CH...

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... facile detection of β -galactosidase activity. This is accomplished with the chromogenic substrate 5-bromo-4-chloro -3 - indoyl- β -D-galactopyrano- side, which is metabolized by β -galactosidase to ... Zetterqulist, H., and Olerup, O., HLA-DR, -DQ, and -DP alleles in nickel, chromium and/ or cobalt-sensitive individuals: genomic analysis based on restriction fragment length polymor- p...

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