Heavy Metals in the Environment - Chapter 11 pot
Heavy Metals in the Environment - Chapter 11 pot
... been
designed using nickel- and histidine-tagged proteins to cross-link proteins of in-
terest for analysis of multiprotein complexes (324). Levine et al. (316) demon-
strated that in the presence ... nickeloplasmin) (91). The primary binding
site of nickel to albumin is a histidine residue at the third position from the amino
terminus of the protein (92). Neighboring residues (...
Heavy Metals in the Environment - Chapter 1 pot
... trapped in the intestinal mucosa, not reaching the systemic circula-
tion to the same extent as in persons with normal zinc intake and therefore in-
creasing susceptibility to copper deficiency. The ... analy-
sis of the current state of knowledge of heavy metals in the environment.
The volume begins with a chapter on the essentiality and toxicity of metals.
Th...
Heavy Metals in the Environment - Chapter 2 pot
... ions. These two oxidation states are the most common in
environmental samples. The redox method using the Fe(II)/Fe(III) system in the
presence of 1,10-phenanthroline and diphosphate in a flow-injection ... of the principal analytical methods
used in environmental sciences for heavy metals determination. The monitoring
of trace metals in the environment has been...
Heavy Metals in the Environment - Chapter 7 pot
... toxic
levels in their drinking water, probably as a consequence of increased agricultural
irrigation. In recent years the toxic potential, both carcinogenic and noncarcino-
genic, of arsenic in drinking ... mg/kg, the former diet pro-
viding a calculated daily intake of approximately 19 µg/ (plus 31 µg from
yams). This intake would be the equivalent of ingesting 1 L of drinking wa...
Heavy Metals in the Environment - Chapter 9 potx
... buthionine sulfoximine was
associated with decreases in the level of single-strand breaks. Interestingly, the
number of DNA-protein cross-links and interstrand cross-links was only margin-
ally ... a decrease in poly-
merase arrest and cross-links but not in total Cr binding, further substantiating
the idea that DNA cross-links are the polymerase-arresting lesion. These observa-...
Heavy Metals in the Environment - Chapter 16 potx
... Dekker, Inc.
copies of Cys-box copper-binding motifs within their heavy- metal-binding do-
mains. Each Cys-box is likely part of an individual subdomain, which together
form the entire copper-binding ... copper-bound form of the protein. The individual Cys-box subdomains
must then fold in relation to each other to form a complete copper-binding do-
main.
Metal binding to the entire...
Heavy Metals in the Environment - Chapter 3 pdf
... vivo.
4.4 Protein-Protein Interactions
Heavy metals have been shown to in uence protein-protein interactions. One
example is the disruption of the E-cadherin/catenin cell adhesion complex via
the displacement ... apoptosis. They have the potential
to interfere with DNA synthesis and repair, the activities of Zn-containing pro-
teins, the correct folding of protein molecules a...
Heavy Metals in the Environment - Chapter 4 pptx
... in the treatment of certain types of can-
cer. Studies with radioactive cis-diaminodichloro-platinum indicate that about
10% of the radionuclide deposits in the liver and a further 10% in the ... ϳ20% in liver (11) . In the blood plasma, indium
is transported on the iron-transport protein transferrin, to which it binds very
strongly (12). Assuming that the human body c...
Heavy Metals in the Environment - Chapter 5 pptx
... DNA lesions,
including single- and double-strand breaks and DNA-protein cross-links (104,
110 116 ), and thereby induce mutations (117 ,118 ). Metals that could generate
radical species include nickel, ... evidence indi-
cates that metals can replace zinc in DNA-binding zinc finger proteins (119 ),
which are typically transcription factors that show a high site-specific DNA bind-
ing (12...
Heavy Metals in the Environment - Chapter 6 pptx
... optimizing conditions for the remediation of As-
contaminated soils using fungi. In addition, there is little information in the litera-
ture on the nature of fungi present in As-contaminated ... scorodite in the mine wastes, generated during
centuries of silver, zinc, and lead mining (126,127), leach As into the aquifers
and cause natural As contamination in the drinkin...