... thisassay). The simplest interpretation of these data rela-tive to the structure of the receptor is that the mini-receptors were in the form of dimers. Byrd et al. [34]showed, via mutational analysis, ... solubleforms of the receptor [25,26,34], indicates that the ectodomain of the receptor is capable of dimer forma-tion in the absence of ligand.Affinity cross-linking of [125I]IGF-II to a mutantrepeat ... such receptor dimers arecapable of binding IGF-II to the wild-type side, butnot to the mutant side of the dimer. Overall, the analysis of IGF-II binding in such receptor dimerssuggests that each...