báo cáo khoa học: " Government use licenses in Thailand: The power of evidence, civil movement and political leadership" ppt

... by the Secretary General of the NHSO, to assess the need for the use of government use licenses and to develop the criteria to guide the selection of medicines for which the government use licenses ... granting and implementation of the government use licenses toenable the import and production of generic versions of medicines patented in Thailand. The aim is to provideinsights into the political ... issues of rising costs of ARVs, pharmaceutical patents and the use of the TRIPS flexibilities. Then, the paper examines the policy and decision-making processes within the gov-ernment in the lead...

báo cáo khoa học: " Government use licenses in Thailand: an assessment of the health and economic impacts" pptx

... changes in national exports and in the short- and long-term foreigninvestment flows into Thailand following the grant of the government use licenses. To study the effects of the government use licenses ... companies [34] and political instability in Thailand, including the call for reconsideration of the government use licenses by the new government [35],are one reason for the diminished level of positiveimpact ... effective monitoring of the implications of the government use licenses and for future related policy decisions in Thailand. The study reveals a number of observations in terms of enabling the successful...

Báo cáo khoa hoc:"Muscle-related traits in cattle: The role of the myostatin gene in the South Devon breed" pps

... in uential than that of its dam in determining the difﬁculty of calving. The objective of this study was to review the impact of the del11 allelefor breeds in which it is segregating. The MLC, which ... improvements in gestation length and calving ease. The genetic parameters and the economicvalues used for these indices are described in detail by Amer and Simm [2].Using the above results for the different ... predicted the impact onBeef and Calving Values.Considering both Beef Value and Calving Value, there is a net gain of the del11 allele in a segregating beef population. The impact on Beef Value of a...

báo cáo khoa học: " Embryonic stem cells in scaffold-free threedimensional cell culture: osteogenic differentiation and bone generation" ppt

... about the use of biomaterials as a scaffold because the physicochemicalproperties of the biomateri als influence the proliferation and gene expression of the cells [9,21,22]. Even proteincoating ... crystal-like structures in the i nterior of the microspheres. These ESC microspheres resemble aggre-gates consisting of preosteoblasts.Our finding of a mineralization in microspheres of DAG-treated ... many other authorscould not find any indication of malignant transforma-tion in their studies [39], the eventuality of cancerinduction is still an argument for the restricted use of these...

Báo cáo khoa học: Modeled ligand-protein complexes elucidate the origin of substrate speciﬁcity and provide insight into catalytic mechanisms of phenylalanine hydroxylase and tyrosine hydroxylase pptx

... sequence of substrate binding in TH [6], the binding of dioxygen prior to the amino acid will promote the placement of tyrosine in the second-ranking, butproductive position.While the unproductive ... BH4 in PAH is shown in red, for BH 4 in TH according to the results of the automated docking in blue, and for BH4 in TH according to the manual docking in the X-ray crystallographic mode in ... inhibition.As the binding sites of catecholamines and BH4overlap in both amino acid hydroxylases, they compete with eachother for obtaining access to the catalytic site. Moreover,bidentate binding of...

báo cáo khoa học: " A randomized trial to assess the impact of opinion leader endorsed evidence summaries on the use of secondary prevention strategies in patients with coronary artery disease: the ESP-CAD trial protocol" doc

... leaders in the out-patient setting, the generalizability of the intervention is of utmost concern. Thus, the focus must be on a practicalmeans of incorporating the influence of these individualsinto ... Simpler,cheaper, and more effective means of increasing the pre-scribing of proven therapies for CAD patients are needed. The potential role of point -of- care reminders and opinion leaders in closing care ... measurerepresenting improvement in statin-related secondaryprevention consisting of: 1) provision of a statin sample,or 2) provision of a statin prescription, or 3) increasing the dosage of a statin within...

Tài liệu Báo cáo khoa học: A systems biology approach for the analysis of carbohydrate dynamics during acclimation to low temperature in Arabidopsis thaliana doc

... metabolism in the cold. Mathemati-cal modelling and simulation of cold-induced metabolic reprogrammingindicated major differences in the rates of interconversion between the pools of hexoses and sucrose, ... assessment of the trajec-tory of interconversion rates as a function of time of cold exposure, (b) comparison of the magnitudes of the various interconversion rates, and (c) lineup of the accessions ... concerning sucrose cycling, weperformed in silico experiments, using the validatedmathematical model in terms of predictive metabolicengineering [18]. Replacing Vmaxvalues and k values in the...

Tài liệu Báo cáo khoa học: "Identifying Linguistic Structure in a Quantitative Analysis of Dialect Pronunciation" docx

... (2006). In both of these papers the identiﬁcation of linguistic structure in the aggregate analysis is based on the analysis of the pronunciation of the vowels found in the data set. In work ... identiﬁcation of the underlyinglinguistic structure of the dialect divisions. It is animportant step towards more general investigation of the role of the regular sound changes in the languagedialect ... explaining 35% of the total amount of vari-ance. The main drawback of applying this technique in dialectometry is that it is not directly related to the aggregate analysis, but is rather an independent...

Báo cáo khoa học: Neural retina leucine-zipper regulates the expression of Ppp2r5c, the regulatory subunit of protein phosphatase 2A, in photoreceptor development pdf

... precipitate the Ppp2r5c and rhodopsinpromoters in the HT22 cell lines. To conﬁrm the asso-ciation of Nrl with the Ppp2r5c promoter in mouse ret-ina, we used postnatal day (P)10 mouse retina for the quantitative ... binding of Nrl to the rhodopsin promoter (Fig. 4C,D). The mRNA tran-script levels of Ppp2r5c and rhodopsin in mouse retinacorresponded to the observed increase in Nrl bindingafﬁnity for their ... HT22 cells, to further examine the binding of Nrl to the Ppp2r5c promoter in vivo. Nrlbinding to the Ppp2r5c and rhodopsin promoters wasexamined by quantitative real-time of ChIP sampleswith...

Báo cáo khoa học: ATP-dependent ligases in trypanothione biosynthesis – kinetics of catalysis and inhibition by phosphinic acid pseudopeptides doc

... agreement with the valueobtained previously by varying the concentration of phosphinate and initiating with enzyme.Modality of inhibition The mode of inhibition of the slow-binding phosphi-nate ... the sequence of CfGspS. These include an insertion of 17amino acids in the amidase domain and two in the synthetase domain (one of 14 amino acids and the Fig. 9. Conservation of key functional residues ... examined the kinetic mechanism of CfGspS and determined the modality of inhibition and potency of these compounds against CfGspS and the homo-logous enzyme TryS from various disease-causingparasites.ResultsInitial...

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