... and proximity to inhibitors and mutations: the flaps, the80¢s loops and the hydrophobic clusters formed by res-idues Ile47, Ile54, Thr80, Ile84 and Ile50¢ from theopposite subunit.The conformation ... interatomic distance of 3.4 A˚ for the major conformation and 3.5 A˚ for the minor APVconformation. Val50¢ also lost hydrophobic interac-tions with the THF group of APV. The minor confor-mation ... contactdistances of 3.4–3.8 A˚ to nitrogen atoms.Alternative conformations were modeled for residuesin all crystal structures. Alternative conformationswere modeled for a total of 48, 13, 28, 11,...