báo cáo khoa học: "National and subnational HIV/AIDS coordination: are global health initiatives closing the gap between intent and practice?" pdf

... article as: Spicer et al.: National and subnational HIV/AIDS coordination: are global health initiatives closing the gap between intent and practice? Globalization and Health 2010 6:3.Submit your next ... delayed the implementation of the Global Fund grant, and in Zambia roles and responsibil-ities were ill-defined between the NAC, MoH, otherministries and CSOs, and between va rious subnational structures ... N: Tracking Global HIV/AIDS Initiatives and their Impact on the Health System: the Experience of the Kyrgyz Republic Final Report Centre for Health System Development, Kyrgyzstan and London School...

Tài liệu Báo cáo khoa học: "STRING-TREE CORRESPONDENCE GRAMMAR: A DECLARATIVE GRAMMAR FORMALISM FOR DEFINING THE CORRESPONDENCE BETWEEN STRINGS OF TERMS AND TREE STRUCTURES" pdf

... between the whole TREE and the whole STRING (tri- vial), between the subtree 4(5(6),7) and the two occurrences of the substring "dog catcher" (non- trivial), etc. We shall do the ... in the form of a labeled tree, and the relation between a string of terms and a structural representation is defined as a mapping between elements of the set of substrings of the string and ... is the design of the multilevel structures, while the grammar formalism is the tool (notation) for expressing these multilevel structures, their related sentences, and the nature of the correspon-...

Báo cáo khoa học: Sensitivity to Hsp90-targeting drugs can arise with mutation to the Hsp90 chaperone, cochaperones and plasma membrane ATP binding cassette transporters of yeast docx

... [27]. They thereforerepresent mutations in the Hsp82 isoform of yeast Hsp90that cause partial, rather than total, loss of the essentialTable 1. The yeast strains employed for this study and their ... afﬁnity of the chaperone for the drug. The IC50forGA inhibition of the in vitro ATPase of puriﬁed yeast Hsp82is unaffected by the A587T mutation (Fig. 2) and similar forboth yeast and human ... present tsphenotypes. Nevertheless there appears to be no correlation between the degrees of drug sensitivity and temperaturesensitivity displayed by these hsp82 strains (compareFig. 1A of this report...

Báo cáo khoa học: LmbE proteins from Bacillus cereus are de-N-acetylases with broad substrate speciﬁcity and are highly similar to proteins in Bacillus anthracis pot

... order to test the suggestion that the loops sur-rounding the active site and the rim of the tunnel are directly implicated in determining the accessibility of the active site and the enzyme’s ... formed through the association of three dimers [10] (PDB ID 2ixd). Dimerization is achievedthrough interaction between the b8-strand of one monomer and the b6- and b7-strands of the other monomer. ... stick models. The distances between the substrate and each of the three residues are shown as dashed lines. (D) Position 42. The native Ala residue (yellow) and the mutation Ser (gray) are shownas...

báo cáo khoa học: "A patient presenting with a perivascular epithelioid cell tumor in the broad ligament: a case report" pdf

... down the right vagi-nal wall and distorting the vagina and bladder. Notumor breach was seen on cystoscopy or sigmoidoscopy.A fistulous connection was found between the tumor and vagina and the ... itimpossible to identify the pelvic vessels, hence the tumor resection was abandoned. The fibrosis extendedup to the kidneys but the ureters w ere freed from the fibrous tissue and an ileal conduit ... stent insertion. The patientunderwent palliative radiotherapy, after which the nephrostomy was removed. Her pelvic pain did notrespond to the radiotherapy and has remained the mainissue.At...

Báo cáo khoa học:" Development of TaqMan® MGB fluorescent real-time PCR assay for the detection of anatid herpesvirus 1?" pdf

... AHV-1detection. From the ratio of the calculated amount of ICto the actual amount of IC, which is shared by the speci-men, the normalization could be achieved and the actualamount of AHV-1 in the specimen ... at lower and higher dilutionsquantitation was not always reproducible compared toother properly diluted samples. Therefore the dynamicrange of the method was between 1.0 × 109 and 1.0 × ... eliminating the need for sample dilution and minimizing sample handling. The results for intra- and inter-assay precision indicate that both intra-assay and inter-assay CVs were satisfactorily low and the...

Báo cáo khoa học: " Development of TaqMan® MGB fluorescent real-time PCR assay for the detection of anatid herpesvirus 1" pdf

... AHV-1detection. From the ratio of the calculated amount of ICto the actual amount of IC, which is shared by the speci-men, the normalization could be achieved and the actualamount of AHV-1 in the specimen ... at lower and higher dilutionsquantitation was not always reproducible compared toother properly diluted samples. Therefore the dynamicrange of the method was between 1.0 × 109 and 1.0 × ... repre-sents the result of triplicate amplification of each dilution. The correlation coefficient and the slope value of the regression curve were calculated and are indicated.Table 1: Intra- and inter-assay...

Báo cáo khoa học: "Pro/con clinical debate: Steroids are a key component in the treatment of SARS" pps

... including the efficacy of this treatment, the appropriate timing ofinitiation of treatment, and the dose and duration oftherapy.Steroid therapy causes significant adverse effects, and thisremains ... used in the treatment ofSARS based on the hypothesis that diseasemanifestations are in part due to the host’s inflammatoryresponse. Many questions regarding the use of steroids in the treatment ... latein the course of unresolving ARDS found improvement inlung injury and mortality [8]. Given these conflicting results,steroid therapy is not generally accepted for the treatment ofARDS and...

Tài liệu Báo cáo khoa học: 3T3-L1 adipocyte apoptosis induced by thiazolidinediones is peroxisome proliferator-activated receptor-c-dependent and mediated by the caspase-3-dependent apoptotic pathway doc

... 30821065 and 30870559 from the China National Nature SciencesFoundation, 2006CB910703 from the Ministry ofSciences and Technology of China, and 07dz05907from the Committee of Sciences and Technology ... one of the prodeath proteins in the Bcl-2 fam-ily, and interacts with prosurvival Bcl-2 family mem-bers to inactivate them [32]. Akt-1 phosphorylates Badat Ser136, inactivating Bad and thereby ... thiazolidinediones (TZDs) are potent promoters of adipogenesisin the preadipocyte, they induce apoptosis in several other cell types,such as cancer cells, endothelial cells and T-lymphocytes. In...

Tài liệu Báo cáo khoa học: Golgi reassembly stacking protein 55 interacts with membrane-type (MT) 1-matrix metalloprotease (MMP) and furin and plays a role in the activation of the MT1-MMP zymogen pdf

... complex The interaction on the one hand between MT1-MMP and GRASP55 and on the other hand between GRASP55 and furin led us to hypothesize thatGRASP55 could potentially play a role in the forma-tion ... in the interaction between TGF-a ICD and the GRASP55PDZ1 domain [37]. Phosphorylation has been found tomodulate interactions between PDZ domains and theirligands [47–49]. The afﬁnity of the ... in the formation of the MT1-MMP–furin complex; therefore,disruption of the interaction between GRASP55 and furin should perturb the activation of pro-MT1-MMP and reduce MT1-MMP activity at the...

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