báo cáo khoa học: " Transparency in Nigeria''''''''s public pharmaceutical sector: perceptions from policy makers" pptx

... establish- ment of such initiatives would require initial investments into Nigeria's manufacturing facilities so that they are in line with WHO Good Manufacturing Practices as a start- ing point. To further ... purposes) and investing in up-to-date technology to assist officers in their work. Purchasing vehicles for inspectors of would halt the practice of having manufacturing comp...

Ngày tải lên: 11/08/2014, 14:21

... protein. Similar to b-RAF, LRRK2 encodes a kinase domain with serine ⁄ threonine activity [7], but in concert with a number of conserved domains, including a GTPase domain. Multidomain proteins ... functional kinase domains often utilize intrinsic protein kinase activity distinct from the canonical protein kinase ⁄ sub- strate interaction. For the same reason that the exis- tence of a LRR...

Ngày tải lên: 23/03/2014, 04:20

... moesin, a protein that anchors the actin cytoskeleton to the plasma mem- brane [24]. Although cytoskeleton proteins are known as frequent ‘contaminants’ in the process of searching binding proteins, ... vesicle proteins by restricting these proteins from going to the dendrites. This result further indicates a critical func- tion of LRK-1 in establishing the polarity of synaptic vesicle...

Ngày tải lên: 23/03/2014, 04:20

... multidomain protein comprising (from N-terminal to C-terminal), armadillo (ARM), ankryn (ANK), LRR, Ras of complex proteins (ROC), C-ter- minal of ROC (COR), mitogen-activated protein kinase kinase kinase ... WD40 domain. Because WD40 domain is involved in mediat- ing protein–protein interactions, the LRRK2 G2385R variant may impact on interactions with substrates and ⁄ or regulatory prote...

Ngày tải lên: 23/03/2014, 04:20

... mPTP-opening induced by rBAX To gain insight into the existence of putative mito- chondrial lipid microdomains in vivo, we evaluated the inducing effect of rBAX on opening of the mPTP in kidney ... Modifications in the cholesterol content in vivo may lead to altera- tions in the physical environment of the membrane, consequently changing the likelihood of certain pro- teins partition...

Ngày tải lên: 07/03/2014, 05:20

... expansion, which consists in creating additional queries using question word synonyms in the purpose of increasing the recall of the search engine. Synonyms are obtained via the WordNet 2.0 3 lexical ... Proceedings of the International Conference Re- search on Computational Linguistics (ROCLING X). C. C. T. Kwok, O. Etzioni, and D. S. Weld. 2001. Scal- ing question answering to the web....

Ngày tải lên: 17/03/2014, 22:20

... important finding in this trial has demonstrated the improvement of PFS and RR from van- detanib translated into the clinically meaningful delay in symptom progression. Competing interests The ... 2008 ASCO annual meeting, also tested erlotinib with platinum/gem- citabine chemotherapy with erlotinib continuing as the maintenance therapy [19]. PFS was statistically better in experiment...

Ngày tải lên: 10/08/2014, 22:21

... life insurance from 1995 to 2000 in a Swedish insurance company (Agria) were included in this study. Most dogs had been enrolled in insurance as puppies, but dogs could have entered the insurance ... drawback with the insurance database is that neuter status is not included. Although, there may be an increasing trend for elective spaying and neutering recently in Sweden, data from...

Ngày tải lên: 12/08/2014, 15:21

... point mutations were initiated aiming at the substitution of glycine residues by alanine or proline and the exchange of proline by glycine. Glycine residues are frequently found at the C-terminal ... substitution of glycine by alanine and proline, respectively, or of proline by glycine (Table 1). Each individual mutation was verified by DNA sequencing using the dideoxynucleotide chain-terminat...

Ngày tải lên: 21/02/2014, 03:20

... media containing 10% fetal bovine serum was added and cells were incubated overnight. Next morning, the cells were washed by DMEM and incubated in DMEM media containing 5% fetal bovine serum and antibiotics ... element binding protein; CRF, corticotropin releasing factor; CRFR1, corticotropin releasing factor receptor; IP3, inositol- 1,4,5-triphosphate; NF-jB, nuclear factor-kappa B; PKA, p...

Ngày tải lên: 07/03/2014, 15:20