báo cáo khoa học: " The production of consumption: addressing the impact of mineral mining on tuberculosis in southern Africa" pdf
báo cáo khoa học: " The production of consumption: addressing the impact of mineral mining on tuberculosis in southern Africa" pdf
... number of mines in the population among southern African nations (r = 0.41, p < 0.01)Figure 1 The relationship of tuberculosis in the general population to the number of mines in the population ... than in miners in the UK? While regulations areweaker in southern Africa, the companies owning the mines and determining typical occupational conditionsare multi-national corporations. The problem ... describescurrent intervention options.DiscussionWhy are miners in southern Africa at high risk of tuberculosis? The mining industry is among southern Africa's largestemployers, particularly in the...
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Báo cáo khoa học: "Case markers and Morphology: Addressing the crux of the fluency problem in English-Hindi SMT" pot
... target side of the train-ing corpus.Training, tuning, and decoding were performedusing the Moses toolkit3. Tuning (learning the λ values discussed in section 4.1) was done usingminimum error ... All meaning is conveyed4 Most of the meaning is conveyed3 Much of the meaning is conveyed2 Little meaning is conveyed1 None of the meaning is conveyedTable 4: Subjective Evaluation: Adequacy ... are faced with the problem of ex-tracting information from the source language sen-tence, transferring the information onto the targetside, and translating this information into the ap-propriate...
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Báo cáo khoa học: A novel R-stereoselective amidase from Pseudomonas sp. MCI3434 acting on piperazine-2-tert-butylcarboxamide pdf
... highlyconserved in the RamA sequence. Production of the R-amidase in E. coliand opticalresolution of racemic piperazine-2-tert-butylcarboxamide by the recombinantE. colicells The direction of ... mMbuffer containing 150 mMNaCl and elutedwith the same buffer. The active fractions were collectedand dialyzed against 10 L of 10 mMbuffer for 12 h. For the determination of the N-terminal amino ... glutamines. Considering the structural formulae of the above substrates, RamA seemedto recognize the carboxamide substrates in which the aminoor imino group is connected to b-orc-carbon of the compounds....
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Tài liệu Báo cáo khoa học: P25a ⁄ TPPP expression increases plasma membrane presentation of the dopamine transporter and enhances cellular sensitivity to dopamine toxicity pptx
... Todistinguish total binding from non-specific binding, cells wereincubated for 10 min in either PBSCM alone or PBSCMcontaining 200 lm cocaine for inhibition of DAT or 200 lmS-citalopram for inhibition ... yielding the supernatant LS2, containing the cytosol-enriched fraction, and the pellet LP2, which isenriched in synaptic vesicles. The protein concentrationswere measured using the bicinchoninic ... which results in a deple-ting of DA in their projection area in the striatum[1,2]. The loss of dopaminergic neurons plays an essen-tial role in causing motor dysfunction, as demonstratedby...
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Tài liệu Báo cáo khoa học: A systems biology approach for the analysis of carbohydrate dynamics during acclimation to low temperature in Arabidopsis thaliana doc
... assessment of the trajec-tory of interconversion rates as a function of time of cold exposure, (b) comparison of the magnitudes of the various interconversion rates, and (c) lineup of the accessions ... integral of carbon uptake perhour. Data points were spline-interpolated to obtain time-continuous information on net photosynthesis during the whole period of cold exposure. The rate of raffinose ... (2004) Impact of soluble sugar concentrations on the acquisi-tion of freezing tolerance in accessions of Arabidopsisthaliana with contrasting cold adaptation – evidence fora role of raffinose in...
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Tài liệu Báo cáo khoa học: Mixed lineage leukemia: a structure–function perspective of the MLL1 protein ppt
... modifi-cations into histones is expected lead to a deeperunderstanding of how transcription initiation, elonga-tion and termination are controlled in the context of chromatin. It is likely that the ... complexes.Binding of the MLL1 Win motif to the central argi-nine-binding pocket of WDR5 raises questions about the proposed role of WDR5 in binding histone H3, atleast while WDR5 is incorporated into the ... to the KIX domain of the cAMPresponse element-binding (CREB) binding protein(CBP) [23], a peptide from the Win motif of MLL1bound to the WD40 repeat protein, WDR5 [24,25] and the C-terminal...
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Tài liệu Báo cáo khoa học: Neuronal growth-inhibitory factor (metallothionein-3): evaluation of the biological function of growth-inhibitory factor in the injured and neurodegenerative brain pdf
... up-regulation and secretion of GIF by astrocytes in the immediate vicinity of a lesion could contribute to the accumulation of reactive astrocytes at the injury site.Interestingly, one study has demonstrated ... secretion in the brainTaken together, the regulation of GIF synthesis byreactive astrocytes, and its subsequent secretion undercertain conditions, could be intimately involved in regulating how the ... suggesting that this MT isoform has different anddistinct functions within the brain. Furthermore, the discovery and continued investigation of this brain-spe-cific MT isoform has led to intense interest...
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Tài liệu Báo cáo khoa học: Ionic strength and magnesium affect the specificity of Escherichia coli and human 8-oxoguanine-DNA glycosylases pdf
... address the in uence of the reaction conditions on the binding of Fpg and OGG1to damaged DNA, we determined Kdvalues for bindingunder the same conditions as used for the kinetic experi-ments. In ... preventing incorporation of 8-oxoG into DNA during replication [7–9]. Inacti-vation of the GO system increases the mutagenesis rate in bacteria [11] and increases the risk of cancer devel-opment in ... In these experiments, fluorescence titration was the method of choice because it allows full control over the composition of the reaction mixture. To minimize the impact of protein binding to non-damaged...
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Tài liệu Báo cáo khóa học: Quantitative analysis, using MALDI-TOF mass spectrometry, of the N-terminal hydrolysis and cyclization reactions of the activation 2 process of onconase pdf
... chloride on the reaction, the reaction rateincreases with increasing concentrations of guanidiniumchloride.Enzymatic removal of the N-terminal methionyl residuefrom other recombinant ribonucleases, ... the conversion of glutaminyl to pyroglutamylresidues. The hydrolysis reaction was monitored by calculating the sum of the relative intensities of the peaks corresponding toGln-ONC (M23L) (theoretical ... effect on the rate of the reaction because, asmentioned previously, AAP remains active, even at highconcentrations of the denaturing agent.Cyclization reaction In contrast to other ribonuclease...
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Tài liệu Báo cáo khoa học: a-Conotoxins as tools for the elucidation of structure and function of neuronal nicotinic acetylcholine receptor subtypes doc
... studies. The highselectivity of the a-conotoxins, together with the possibility of obtaining detailed information on their three dimen-sional structures and the relative ease of synthesis, makesthem ... in acloning approach making use of the high conservation of the 3¢ untranslated region and the intron preceding the sequence of the a-prepropeptide [39]. The peptide wascharacterized on oocyte-expressed ... concentrations,protocols for toxin application or determination of the toxin concentration) have to be considered.a-Conotoxin SequenceaFunctional DataBinding Data (nM)cIC50(nM) on...
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