báo cáo khoa học: " Transcriptome instability in colorectal cancer identified by exon microarray analyses: Associations with splicing factor expression levels and patient survival" docx

... sTIN / oTIN Splicing Stage MSI-status sTIN oTIN -1 0 1 Splicing Stage MSI-status sTIN oTIN Figure 3 Hierarc hical clustering analyses of CRC test samples by expression levels of all splicing factors. ... Bioinformatics 2008, 9:559. doi:10.1186/gm248 Cite this article as: Sve en et al.: Transcriptome instability in colorectal cancer identified by exon microarray...

Ngày tải lên: 11/08/2014, 12:21

... cetuximab-containing regimens may be improved by combining it with other predictive factors. [15] determined the KRAS mutation status and mRNA expression levels of the EGFR ligands amphiregulin and epiregulin ... epiregulin in 95 patients with primary CRC treated with cetuximab and irinotecan and correlated these variables with response and overall survival. They fou...

Ngày tải lên: 10/08/2014, 22:20

... infiltrated with Psg carrying avrB (HR) and compared to those RNAs from plants infil- trated with MgCl 2 at three time points post inoculations (2, 8 and 24 hrs) and labeled as T2HR, T8HR, and ... Pathway BA2H CHR/ IFS1 IFS2 ISOFLAVONES ISOFLAVANONES Daidzein Genistein IOMT IFR1 IFR2 Pterocarpan Glyceollin II PHYTOALEXINS UFGT UFGT UFGT Pelargonidin-3-glycoside Cyanidin-3-glycosi...

Ngày tải lên: 12/08/2014, 05:20

... angio- genesis in both embryogenesis and adulthood, and functions by binding with two tyrosine kinase recep- tors, VEGFR-1 (Flt-1) and VEGFR-2 (KDR ⁄ Flk-1), Fig. 1. The VEGF–VEGFR system and the inhibitors ... cells and astrocytes, and the tight junctions of vascular endothelial cells (ECs) in the BBB are well organized with claudins and ZO- proteins through a decreas...

Ngày tải lên: 18/02/2014, 11:20

... more regulatory role by interacting mainly with Hsp90 to ubiquitinate signaling proteins. It has been shown in vitro and in cell culture that sev- eral Hsp90 clients are ubiquitinated in a CHIP-depen- dent ... 17–24) with wild-type ubiquitin (lanes 9–12 and 17–20) or the lysine-free ubiquitin variant Ubi-K0, in which all lysines were replaced by arginines (lanes 13–16 and...

Ngày tải lên: 15/03/2014, 23:20

... physician identifiers in this database and by their caseload of NPC patients. The volume category cutoff points (high, medium, and low) were determined by sorting the 1225 patients into 3 groups of ... years 1998 and 2000 were included. Patients with unclear treatment mod- ality and incomplete physician data or treated by physi- cians with a very small caseload (less than...

Ngày tải lên: 09/08/2014, 09:20

... between -1% and -2% for 2, between 1% and 2% for 4, and within -1% and 1% for 20 measured HLUT points. Analysis of tissues involved in typical head and neck treatments, namely brain, fat, and neck, ... result from small tissue inho- mogeneities. In addition to range straggling these inho- mogeneities lead to differences in ion ranges within a beam spot resulting in broaden...

Ngày tải lên: 09/08/2014, 10:21

... were disappointing in that the ORR and OS appear inferior to standard cisplatin-based regi- mens. Vinflunine Vinflunine is a novel vinca alkaloid that inhibits tubulin and acts to inhibit assembly ... exciting findings in the field of prostate cancer is the recognition that persistent androgen signal- ing remains critical in CRPC. Approaches to targeting androgen signaling includi...

Ngày tải lên: 10/08/2014, 22:20

... well as in combination with vinor- elbine in patients with advanced breast cancer. [11] These investigations appear promising and may allow for fur- ther treatment options for patients with advanced ... cetuximab in combination with irinotecan in a phase II study in patients with MBC previously treated with an anthracy- cline or a taxane-based therapy.[21] In this s...

Ngày tải lên: 10/08/2014, 22:20

... athletes showing high reproducibility [3,13]. DXA was originally developed to examine bone mineral density and examines the body in mm 3 dividing the human body in three parts: bone, fat- and bone ... mass by 12.1% points. The largest individual overestimation of fat mass by BIS was found in a soccer player having a fat mass of 5% assessed by DXA and 11% assessed by BIS,...

Ngày tải lên: 11/08/2014, 07:20