báo cáo khoa học: " Overcoming bias and systematic errors in next generation sequencing data" ppt

... solutions. © 2010 BioMed Central Ltd Overcoming bias and systematic errors in next generation sequencing data Margaret A Taub* 1 , Hector Corrada Bravo 2 and Rafael A Irizarry* 1 CO M MENTA ... MA, et al.: Overcoming bias and systematic errors in next generation sequencing data. Genome Medicine 2010, 2:87. Taub et al. Genome Medicine 2010, 2:87 http://g...

Ngày tải lên: 11/08/2014, 12:21

... Pipetting errors arise from differences in cell number, gel loading and antibody detection, while blotting errors are caused by inhomogeneities of the gel or the blot. Eliminating correlated errors ... using the protein standard depicted in Fig. 1. Smoothing spline curves through original and normalized data are shown as solid lines. M. Schilling et al. Strategies for standardiz...

Ngày tải lên: 19/02/2014, 07:20

... degrees of instantiation in LTFS, however, corresponding to long subtyping chains that terminate in ⊥. A more general and useful primitive in a typed language with such chains is suspending until ... suspending until a variable is instantiated, and (2) suspending until two variables are equated or inequated. The latter corresponds exactly to structure-sharing in TFSs, and to sha...

Ngày tải lên: 20/02/2014, 15:21

... Restructuring Verbs in Italian HPSG Grammar. In Proceedings of the 29th Regional Meeting of the Chicago Lin- guistic Society, 1993. To appear. [Pollard andSag, 1987] C. Pollard and I. Sag. Information-Based ... lure, and I. Sag. Generalized Phrase Structure Grammar. Blackwell, 1985. [Hinrichs and Nakazawa, 1990] E. Hin- richs and T. Nakazawa. Subcategorization and...

Ngày tải lên: 22/02/2014, 10:20

... biochemical model, including creating it, storing it, editing it, com- paring it with other stored models, finding it again in a principled way, visualizing it, sharing it, running it, analysing the results ... and is crucial in scientific discovery’, the pioneering work by Swanson on hypo- thesis generation [299] is mainly credited with sparking interest in text mining techniques in...

Ngày tải lên: 07/03/2014, 12:20

... neuron. The turning point upon which the cell looses the ability to buffer the incoming calcium resulting in an abrupt, sustained and irreversible increase in [Ca 2+ ] c , probably coincides with ... element binding protein, iso- citrate dehydrogenase is an RNA-binding protein, while kgd2p is a mitochondrial DNA binding protein [81–84]. Mitochondria from different brain regions contain...

Ngày tải lên: 07/03/2014, 12:20

... A minor, splicing-independent pathway invol- ving endonucleolytic cleavage within the intron has also been identified in yeast and rat [33,45–48]. In addition, in plants and certain yeasts, snoRNAs ... miRNAs. Second, a single gene can host several snoRNAs in various introns, but a gene contains in general only one intronic miRNA, or one cluster of miRNAs in a single intron. Th...

Ngày tải lên: 07/03/2014, 16:20

... connecting input to out- put. The training data consists of letter strings paired with phoneme strings, without explicit links con- necting individual letters to phonemes. The subtask of inserting ... combined loss function as an equally-weighted linear combination of the 0-1 and phoneme loss functions. MIRA training is similar to averaged perceptron training, but instead of finding the sing...

Ngày tải lên: 08/03/2014, 01:20

... therefore, requires a finer grain substation method than simply inserting the highest level non-terminals in the in the ellipsed input in place of the matching non-terminals in the parse tree ... abound in our data (as explained in the following section). Developing robust parsing techniques that tolerate errors has been the focus of our earlier investigations [2, 9. 7] a...

Ngày tải lên: 08/03/2014, 18:20

... the CXC chemokine interleukin-8 (GRO ⁄ CINC-1) in response to lipopolysac- charide. The presence of H4-v.1 and histogranin mRNAs in tissues wherein immune reactions take place and the inhibitory ... been described in detail [66]. Amplicons were cloned into the pCR 4-TOPO vector 2.0 using the TOPO TA cloning kit for sequencing (Invitro- gen), transformed, plated as outlined within...

Ngày tải lên: 16/03/2014, 13:20