báo cáo khoa học: "The pharmacogenetics of imanitib" ppsx

... studies of IM and highlight the genetic markers that could be used to improve the treatment and management of diseases for which IM is used. © 2010 BioMed Central Ltd The pharmacogenetics of imanitib Stéphanie ... could modulate the effi cacy of IM and aff ect its mechanism of action. Acquired point mutations in the tyrosine kinase domain of BCR-ABL are the most frequent mech...

Ngày tải lên: 11/08/2014, 12:21

... presence of hemocyanin in a broad range of ametabolous and hemimetabolous hexapod taxa. We obtained a total of 12 full-length and 5 partial cDNA sequences of hemo- cyanins from representatives of Collembola, ... hemolymph of many arthropod species [1–4]. They are composed of six identical or similar subunits with molecular masses of around 75 kDa [1,3]. A subunit may bind to a...

Ngày tải lên: 18/02/2014, 08:20

... amount of precipitation in the presence of high concentrations of Arg-HCl in the absence of the chaperone precluded analysis of the effect of this concentration on the protective ability of aB-crystallin. Reduction-induced ... 1A). Addition of aB-crystallin at a 1.0 : 1.0 w ⁄ w ratio of a-lactalbumin : aB-crystallin decreased the precipi- tation of a-lactalbumin by 81 ± 8%...

Ngày tải lên: 18/02/2014, 16:20

... mononucleosome size of samples con- sisting of a mixture of hepta-, octa- and nonanucleosomes and half the amount of hexa- and decanucleosomes (6- to 10-mer sample). (A) (a) Nonamer of a sequential ... [4]. The fibre consists of the entire chroma- tin of the nucleated avian erythrocytes and comprises approximately 85% of the chromatin in other cell types [5]. The structure of...

Ngày tải lên: 18/02/2014, 18:20

... or M.HhaI. The extent of the methylation is almost independent of the position of the damaged guanine residue X + . Discussion The goal of our study was to elucidate the effect of stereochemistry ... The relative fraction of bound 32 P-labeled DNA (R) is the ratio of the fraction of bound 32 P-labeled DNA in the presence of the competitor DNA (cpm bound ⁄ cpm total ) to the...

Ngày tải lên: 19/02/2014, 00:20

... Because of the lower affinity of the antibody, the amount of total protein used for immunoprecipitation of the X807R mutant was three times that used for wild-type and other mutants. (D) Lysates of ... relative lack of the 130 kDa isoform of the K650M mutant. Endo H digestion of the immunoprecipitated wild-type and Y373C receptors after BFA treatment revealed a partial conversi...

Ngày tải lên: 19/02/2014, 00:20

... cycles of steepest descent followed by 50 cycles of conjugate gradients and 50 cycles of steepest descent). No clashes were detected at the dimer interface of the models or in the surroundings of ... carboxylates of residues Asp38 and Glu111. In RNase-AA-GG the ‘basic sur- face’ is more similar to that of BS-RNase because of the removal of the four carboxylates. The ‘basic s...

Ngày tải lên: 19/02/2014, 06:20

... chemical instability of DNA. To protect the vital genetic information from the deleterious effects of DNA injury a net- work of genome care-taking mechanisms has evolved of which a set of DNA repair ... Molecular Basis of Disease 3.1 Oxidative Stress S3.1-1 The role of antioxidants in the cytotoxicity of chemotherapeutic drugs T. Ozben, H. Akbas, I. Akan, S. Akan and M. Timur...

Ngày tải lên: 19/02/2014, 07:20

... addition of 100 lLof2· Kirby buffer [25] and 80 lLofH 2 O, and rRNA was obtained by precipitation after two phenol– chloroform extractions. Four micrograms of rRNA were treatedwith20lL of acetic-aniline ... effect of substitutions made at each of the arginyl residues on catalytic activity of RTA, the ability of each of the purified RTA variants to depurinate yeast ribosomes was...

Ngày tải lên: 19/02/2014, 12:20

... The N-terminal half of i lysozymes is homologous to the second exon of vertebrate c-type lysozymes (Fig. 3 and [10]). Fig. 4B shows the HCA plot of this part of the human lysozyme. A number of hydrophobic ... Putative three-dimensional model of the Asterias lysozyme i. These figures were generated with the help of the SWISS - PDBVIEWER software. (A) Apartoftheputativestructureoft...

Ngày tải lên: 19/02/2014, 12:20