báo cáo khoa học: " Environmental exposures and mutational patterns of cancer genomes" potx

... cancer exemplify what type of information can be gained from cancer genome sequencing. © 2010 BioMed Central Ltd Environmental exposures and mutational patterns of cancer genomes Gerd P Pfeifer* M ... understanding the initial exposures leading to DNA damage, repair and eventually to mutation of specic sequences within a cancer genome. Two recent studies of m...

Ngày tải lên: 11/08/2014, 12:20

... gene, and the essence of most of the conserved amino acids has been further substantiated by site-directed mutagenesis of FHT [7,9] and by documentation of ligand binding in crystalline DAOCS and ... functionally proved and the lability of substrate and product rule out any cocrys- tallization. The setting of a helices and b-strands causes very similar CD spectra for t...

Ngày tải lên: 21/02/2014, 03:20

... to quickly and cheaply evaluate the impact of new ideas, algorithms, and data sets. BLEU and re- lated metrics work by comparing the output of an MT system to a set of reference (‘gold standard’) translations, ... communicative goal; and that corpus texts are often not of high enough qual- ity to form a realistic test. 2.2 Automatic evaluation of generated texts in MT and...

Ngày tải lên: 24/03/2014, 03:20

... Laboratory of Cell Differentiation and Apoptosis of Ministry of Education of China, Shanghai Jiao Tong University, China An embryo is a stage in the development of plants, invertebrate and vertebrate ... Transcripts of Wnt3a, -6, -7b, -9a and -10b have been detected in blastocysts, and Wnt1 and -4, Sfrp1 and Dkk1 are highly expressed at this stage [37]. Receptors (Fz2,...

Ngày tải lên: 30/03/2014, 03:20

... reflects the profile of the imaging tip rather than of the rupture. Further illustrating the range and variation of cell mor- phologies, and the potential effect the thick layer of poly- mer has ... physical and chemical approach may yield a better understanding into cell functionality and mechanics. Artifacts in the form of bubbles caught trapped between the cell and poly...

Ngày tải lên: 11/08/2014, 00:22

... sequencing of the candidate genes. HHG and AG participated in the design and coordination of the study, interpretation of the data and the development of the manuscript. All authors read and approved ... large number of markers and is therefore expensive and sta- tistically complex [3]. The number of markers to be employed depends on the genome size and t he extent...

Ngày tải lên: 12/08/2014, 03:21

... history of depression was present in 11.1% of the sample (8.2% of men and 13.6 % of wome n, sex differ- ence: z = 4.98, p < 0.001). Abnormal fatigue was present in 25.3% (21.4% of men and 28.6% of ... 10 of 10 (standard of living, early school leaving, and life events) were associated with history of depression through the influence of nonshared environments (E) (...

Ngày tải lên: 11/08/2014, 16:22

... dis- tribution of the energy between the overall tumbling and the internal mobility, and is indicative of the degree of internal restraint of each 15 N– 1 H vector motion. In Fig. 4, most of the points ... minima of J(0) and J(x N ) and a significant maximum of J(0.87x H ), and that emerges not only within helix III, but also over a large portion of the protein, from...

Ngày tải lên: 18/02/2014, 16:20

... Pro, Val or Lys, c-carboxylation of Glu, glycosylation of Ser or Thr, bromination of Trp, sulfation of Tyr, cyclization of N-terminal Gln, and epimerization of several different residues. It ... structure of conomarphin was similar to those of other conotoxin cDNAs. The cDNA-encoded precursor of conomarphin consisted of a conserved M-superfamily signal peptide of 25 re...

Ngày tải lên: 18/02/2014, 17:20

... Araujo Soares RM (2006) Secretion of serine peptidase by a clinical strain of Candida albicans: influence of growth conditions and cleavage of human serum proteins and extracellular matrix components. ... effect of a 5 lm concentration of trappin-2 towards C. albicans was time-dependent, reaching 92% after 6 h and 98% after 18 h (Fig. 5). Effect of NaCl and heparin on the...

Ngày tải lên: 18/02/2014, 17:20