báo cáo khoa học: " Predictive biomarker discovery through the parallel integration of clinical trial and functional genomics datasets" potx
báo cáo khoa học: " Predictive biomarker discovery through the parallel integration of clinical trial and functional genomics datasets" potx
... 2:53 http://genomemedicine.com/content/2/8/53 Page 5 of 10 CORRE S P O NDEN C E Open Access Predictive biomarker discovery through the parallel integration of clinical trial and functional genomics datasets Charles Swanton 1,2*† , ... enable the rapid development of the next generation of predictive biomarkers across a wide range of solid tumor types....
Ngày tải lên: 11/08/2014, 12:20
Báo cáo khoa học: "A concurrent approach to the automatic extraction of subsegmental primes and phonological constituents from speech" docx
... terms of total amplitude or energy distribution ED across low, middle and high frequency parts of the vocal range and the angular frequencies to(F) and amplitudes a(F) of formants. The first ... and before the full identity of a segment has been established. The overall architecture of the recognition task is shown in Figure 1. At Stage 1, the recogniser che...
Ngày tải lên: 31/03/2014, 04:20
Báo cáo khoa hoc:" Simulation analysis to test the influence of model adequacy and data structure on the estimation of genetic parameters for traits with direct and maternal effects" ppsx
... effects and the contribution of the dam to the genotype of her offspring, the direct genetic variance being inflated by part of the genetic maternal variance. It seems that another part of maternal heritability ... unconnected), the four levels of pedigree information (100, 50, 20 and 10% of paternity known) and degree of genetic differences among flocks (GD0, GD...
Ngày tải lên: 09/08/2014, 18:21
báo cáo khoa học: " A linkage map for the B-genome of Arachis (Fabaceae) and its synteny to the A-genome" doc
... example of synteny between A- and B- genomes of Arachis and MedicagoFigure 2 An example of synteny between A- and B- genomes of Arachis and Medicago. Alignment of linkage group B3 of the developed ... not observed in the tetraploid map. The integration of the A- and B-genome Arachis maps effectively increases the information content of both maps. The A...
Ngày tải lên: 12/08/2014, 03:20
báo cáo khoa học: " Inorganic polyphosphate occurs in the cell wall of Chlamydomonas reinhardtii and accumulates during cytokinesis" docx
... between the signal intensity of the staining, the measured poly P content and the supply of potassium phosphate in the medium (Fig. 3). Analysis of cell wall bound poly P during the cell cycle In the ... participated in the design of the study and revised the manuscript critically for important intellectual content. FMF carried out the design of the study...
Ngày tải lên: 12/08/2014, 05:20
Báo cáo y học: "Improved variant discovery through local re-alignment of short-read next-generation sequencing data using SRMA" pot
... positio n on the forward strand, and with its offset set as the number of bases from the beginning of the insertion. Insertions at the same reference position can be combined by mer- ging the paths ... be low at the 5’ end (the beginning) of the sequence read and higher towards the end of each read, but that is not modeled here. The distance between the two...
Ngày tải lên: 09/08/2014, 22:23
báo cáo khoa học: "Predictive genetic testing for the identification of high-risk groups: a simulation study on the impact of predictive ability" pot
... with and without AMD) and the AUC was 0.76 (95% confi dence interval 0.74 to 0.78). We observed the same impact of the relative magnitude of the size of the high-risk groups and disease risk on the ... PPV of the test are strongly influen ced by the relative magnitude of the size of the high-risk group and the disease risk in the popu- lation. In ad...
Ngày tải lên: 11/08/2014, 12:21
Tài liệu Báo cáo khoa học: Stefin A displaces the occluding loop of cathepsin B only by as much as required to bind to the active site cleft doc
... stefin A and the different enzymes is the average distance between the centre of mass of CA atoms of the stefin molecule and the centre of mass of the CA atoms of the reactive site cysteine and histidine ... A comparison of the structure of the unli- ganded cathepsin B with the structure of the proenzyme, its complexes with chagasin and stefin A sh...
Ngày tải lên: 18/02/2014, 04:20
Tài liệu Báo cáo khoa học: Branched N-glycans regulate the biological functions of integrins and cadherins doc
... and biological function. For example, only N-glycans located on either the b-propeller of a 5 [55] or the I-like domain of b 1 or b 3 [68] contribute to the regulation of integrin function. Therefore, ... modifi- cation of particular sites, which are involved in regula- tion of the conformation of integrin, determine the extent of cell migration. The mutual regulati...
Ngày tải lên: 18/02/2014, 17:20
Tài liệu Báo cáo khoa học: Bone morphogenetic proteins in the early development of zebrafish pptx
... synthesized in the Spemann organizer, namely Follistatin, Chordin and Noggin [12]. These proteins are antagonists of BMP and other members of the TGF-b family, binding to and inhibit- ing these ... Bind- ing of the ligand to the receptor complex induces the type II receptor to phosphorylate the type I receptor, which then leads to activation of the type I receptor....
Ngày tải lên: 19/02/2014, 00:20