báo cáo khoa học: " Predictive biomarker discovery through the parallel integration of clinical trial and functional genomics datasets" potx
báo cáo khoa học: " Predictive biomarker discovery through the parallel integration of clinical trial and functional genomics datasets" potx
... 2:53http://genomemedicine.com/content/2/8/53Page 5 of 10CORRE S P O NDEN C E Open Access Predictive biomarker discovery through the parallel integration of clinical trial and functional genomics datasetsCharles Swanton1,2*†, ... enable the rapid development of the next generation of predictive biomarkers across a wide range of solid tumor types. Integration of personalized functional genomics into the clinical setting The ... advances in the therapeutic management of RCC, there are no established predictive biomarkers of response to these agents in RCC or other solid tumortypes, and in excess of 30% of patients will...
- 10
- 302
- 0
Báo cáo khoa học: "A concurrent approach to the automatic extraction of subsegmental primes and phonological constituents from speech" docx
... terms of total amplitude or energy distribution ED across low, middle and high frequency parts of the vocal range and the angular frequencies to(F) and amplitudes a(F) of formants. The first ... and before the full identity of a segment has been established. The overall architecture of the recognition task is shown in Figure 1. At Stage 1, the recogniser checks for the presence of ... word candidate at the end of Stage 2, but if several candidates are available, recognition moves on to Stage 3. Here, the focus is on the four resonance elements. As the manifestations of U,...
- 5
- 337
- 0
Báo cáo khoa hoc:" Simulation analysis to test the influence of model adequacy and data structure on the estimation of genetic parameters for traits with direct and maternal effects" ppsx
... effects and the contribution of the damto the genotype of her offspring, the direct genetic variance being inflated bypart of the genetic maternal variance. It seems that another part of maternalheritability ... unconnected), the four levels of pedigree information (100, 50, 20 and 10% of paternity known) and degree of genetic differences among flocks (GD0, GD10, GD20 and GD30). The average and the empirical standard ... moreimportant.Regardless of the level of connectedness, the alteration of genealogicalinformation, through a progressive elimination of paternity, acted on the pre-cision of variances and covariance,...
- 27
- 431
- 0
báo cáo khoa học: " A linkage map for the B-genome of Arachis (Fabaceae) and its synteny to the A-genome" doc
... example of synteny between A- and B- genomes of Arachis and MedicagoFigure 2An example of synteny between A- and B- genomes of Arachis and Medicago. Alignment of linkage group B3 of the developed ... notobserved in the tetraploid map. The integration of the A- and B-genome Arachis mapseffectively increases the information content of bothmaps. The A-genome map contains candidate genes and QTLs ... participated in the development and analy-sis of SSR and STS markers and drafting the manuscript.DMTAF carried out the identification and analysis of SNPmarkers. CT and MMC participated in SSR and STS...
- 10
- 399
- 0
báo cáo khoa học: " Inorganic polyphosphate occurs in the cell wall of Chlamydomonas reinhardtii and accumulates during cytokinesis" docx
... between the signal intensity of the staining, the measured poly P content and the supply of potassium phosphate in the medium (Fig. 3).Analysis of cell wall bound poly P during the cell cycleIn the ... participated in the design of the study and revised the manuscript critically for important intellectualcontent. FMF carried out the design of the study and drafted the manuscript. All authors read and ... slightly during cytokinesis and increased again slowly towards the end of the darkphase. Therefore, we assume that the low levels of cell wallpoly P and the high levels of intracellular poly P...
- 11
- 258
- 0
Báo cáo y học: "Improved variant discovery through local re-alignment of short-read next-generation sequencing data using SRMA" pot
... positio n on the forward strand, and with its offset set as the number of bases from the beginning of the insertion. Insertionsat the same reference position can be combined by mer-ging the paths ... below at the 5’ end (the beginning) of the sequence read and higher towards the end of each read, but that is notmodeled here. The distance between the two ends of each paired end read was randomly ... the majority of the reads support the presence of the deletion and SNP, while false variation has been eliminated. The Integrated Genomics Viewer was used to view the alignments[30].Homer and...
- 12
- 330
- 0
báo cáo khoa học: "Predictive genetic testing for the identification of high-risk groups: a simulation study on the impact of predictive ability" pot
... with and without AMD) and the AUC was 0.76(95% confi dence interval 0.74 to 0.78). We observed the same impact of the relative magnitude of the size of the high-risk groups and disease risk on the ... PPV of the test arestrongly influen ced by the relative magnitude of the size of the high-risk group and the disease risk in the popu-lation. In addition, selection of high-risk groups withclinically ... Medical Systems Biology (CMSB)in the framework of the Netherlands Genomics Initiative (NGI). Furthermore,this project was sponsored by the VIDI grant of the NetherlandsOrganization for Scientific...
- 8
- 379
- 0
Tài liệu Báo cáo khoa học: Stefin A displaces the occluding loop of cathepsin B only by as much as required to bind to the active site cleft doc
... stefin A and the different enzymes is the averagedistance between the centre of mass of CA atoms of the stefin molecule and the centre of mass of the CA atoms of the reactive site cysteine and histidine ... A comparison of the structure of the unli-ganded cathepsin B with the structure of the proenzyme, its complexes withchagasin and stefin A shows that the magnitude of the shift of the occlud-ing ... trunk of stefin A can displace the ABCDFig. 3. The extent of the occluding loop dis-placement in the unliganded and ligandedstructures. The occluding loop (red) isshown in on the surface of the...
- 8
- 632
- 0
Tài liệu Báo cáo khoa học: Branched N-glycans regulate the biological functions of integrins and cadherins doc
... and biological function. For example, only N-glycanslocated on either the b-propeller of a5[55] or the I-likedomain of b1or b3[68] contribute to the regulation of integrin function. Therefore, ... modifi-cation of particular sites, which are involved in regula-tion of the conformation of integrin, determine the extent of cell migration. The mutual regulation of GnT-III and E-cadherinTo ... Down-regulation of the alpha-Gal epitope expression in N-gly-cans of swine endothelial cells by transfection with the N-acetylglucosaminyltransferase III gene. Modulation of the biosynthesis of terminal...
- 10
- 477
- 0
Tài liệu Báo cáo khoa học: Bone morphogenetic proteins in the early development of zebrafish pptx
... synthesized in the Spemannorganizer, namely Follistatin, Chordin and Noggin[12]. These proteins are antagonists of BMP and othermembers of the TGF-b family, binding to and inhibit-ing these ... Bind-ing of the ligand to the receptor complex induces the type II receptor to phosphorylate the type Ireceptor, which then leads to activation of the type Ireceptor. The signal is passed on to the ... Smad4). The complexes move into the nucleus and act asregulators of transcription. The activity of BMP isregulated by the binding of extracellular inhibitors. The roles and functions of BMPs...
- 8
- 845
- 0
Từ khóa: Báo cáo thực tập tại nhà thuốc tại Thành phố Hồ Chí Minh năm 2018Nghiên cứu sự biến đổi một số cytokin ở bệnh nhân xơ cứng bì hệ thốngNghiên cứu vật liệu biến hóa (metamaterials) hấp thụ sóng điện tử ở vùng tần số THzGiáo án Sinh học 11 bài 13: Thực hành phát hiện diệp lục và carôtenôitĐỒ ÁN NGHIÊN CỨU CÔNG NGHỆ KẾT NỐI VÔ TUYẾN CỰ LY XA, CÔNG SUẤT THẤP LPWANQuản lý hoạt động học tập của học sinh theo hướng phát triển kỹ năng học tập hợp tác tại các trường phổ thông dân tộc bán trú huyện ba chẽ, tỉnh quảng ninhPhát triển mạng lưới kinh doanh nước sạch tại công ty TNHH một thành viên kinh doanh nước sạch quảng ninhNghiên cứu về mô hình thống kê học sâu và ứng dụng trong nhận dạng chữ viết tay hạn chếThơ nôm tứ tuyệt trào phúng hồ xuân hươngSở hữu ruộng đất và kinh tế nông nghiệp châu ôn (lạng sơn) nửa đầu thế kỷ XIXChuong 2 nhận dạng rui roQuản lý nợ xấu tại Agribank chi nhánh huyện Phù Yên, tỉnh Sơn La (Luận văn thạc sĩ)BT Tieng anh 6 UNIT 2Tranh tụng tại phiên tòa hình sự sơ thẩm theo pháp luật tố tụng hình sự Việt Nam từ thực tiễn xét xử của các Tòa án quân sự Quân khu (Luận văn thạc sĩ)Giáo án Sinh học 11 bài 15: Tiêu hóa ở động vậtchuong 1 tong quan quan tri rui roGiáo án Sinh học 11 bài 14: Thực hành phát hiện hô hấp ở thực vậtGiáo án Sinh học 11 bài 14: Thực hành phát hiện hô hấp ở thực vậtMÔN TRUYỀN THÔNG MARKETING TÍCH HỢPQUẢN LÝ VÀ TÁI CHẾ NHỰA Ở HOA KỲ