báo cáo khoa học: " Shared pathways to infectious disease susceptibility?" ppt
báo cáo khoa học: " Shared pathways to infectious disease susceptibility?" ppt
... studies of immune response defects and infec-tious disease outcomes strongly suggested that infectious diseases would have shared pathways to disease. Severe combined immune deficiency (SCID) ... innate detection mechanisms may not be as shared among diseases as immune response mechanisms.© 2010 BioMed Central Ltd Shared pathways to infectious disease susceptibility?Chiea C Khor1,2 ... in broad, general susceptibility to multiple infectious diseases. Elucidation of the respon-sible genes and pathways often yields considerable insight into disease mechanisms and pathogenesis,...
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báo cáo khoa học: " Transcriptional responses to polycyclic aromatic hydrocarbon-induced stress in Arabidopsis thaliana reveal the involvement of hormone and defense signaling pathways" pdf
... receptor ETR1 cause enhanced sensitivity and exaggerated response to ethylene in Arabidopsis. Plant Physiol 2002, 129:1557-1567.36. Tosti N, Pasqualini S, Borgogni A, Ederli L, Falistocco ... AtGSTU24 has previously been shown to be sharply and rapidly induced by the herbicides ace-tochlor and metolachlor, as well as the explosives 2,4,6-trinitrotoluene and hexahydro-1,3,5-trinitro-1,3,5-triaz-Weisman ... P, Selbig J, Müller LA, Rhee SY, Stitt M: MAPMAN: a user-driven tool to display genomics data sets onto diagrams of metabolic pathways and other biological processes. Plant J 2004, 37:914-939.54....
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Tài liệu Báo cáo khoa học: Emerging pathways in genetic Parkinson’s disease: Autosomal-recessive genes in Parkinson’s disease – a common pathway? docx
... these pathways may converge to influence proteinfolding, protein stability and ultimately mitochondrial functionwhich appear to be central to the mechanism of neuronal cell deathin PD.Autosomal ... DJ-1 in mitochondrial function, the fact thatDrosophila lacking DJ-1 exhibit increased sensitivity to environmental mitochondrial toxins [44,51] does point to a role for DJ-1 in mitochondrial ... suggested to protect against oxidative stress byphosphorylating the mitochondrial chaperone tumournecrosis factor receptor-associated protein 1 (TRAP1)Autosomal recessive genes in Parkinson’s disease...
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Tài liệu Báo cáo khoa học: Emerging pathways in genetic Parkinson’s disease: Potential role of ceramide metabolism in Lewy body disease pptx
... bodies [17–19].Pantothenate kinase is an essential regulatory enzymein co-enzyme A biosynthesis, catalyzing the cytosolicphosphorylation of pantothenate (vitamin B5),N-pantothenoylcysteine ... disease) may bemisleading attempts to find common pathways to pathogenesis. Rather, wesuggest, grouping the different loci which lead to different Lewy body disease may be more revealing. Doing ... inclusion pathology.For Alzheimer’s disease, when pathology was used asa basis to understand the disease, pathways involvedbecame evident. This would be most unlikely to happen if, instead, clinical...
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Tài liệu Báo cáo khoa học: Hypoxic resistance to articular chondrocyte apoptosis – a possible mechanism of maintaining homeostasis of normal articular cartilage pdf
... considered to be a key factor in thegrowth and survival of chondrocytes.Hypoxia is known to regulate the expression ofmany genes, but little is known about its role in eitherapoptosis or anti-apoptosis, ... HCT116 cells to proteasome inhibitors. Int JOncol 24, 935–941.19 Falchuk KH, Goetzl EJ & Kulka JP (1970) Respiratorygases of synovial fluids. An approach to synovial tissuecirculatory–metabolic ... sodium-containing medium for 10 min to allow de-esteri-fication to occur. The cells were then collected, and the flu-orescence signals corresponding to intracellular ROS weremonitored at 490 nm excitation...
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Tài liệu Báo cáo khoa học: Calcium-binding to lens bB2- and bA3-crystallins suggests that all b-crystallins are calcium-binding proteins pptx
... binding to this crystallin by ITC anddetermined the binding constant for the calciummimic probe. Terbium is believed to bind strongly to calcium-binding sites of proteins compared to calciumdue to ... these contradictory observations, it is important to investigate whether b-crystallins from vertebrate lensesbind calcium or not.In this context, to establish calcium-binding to theindividual ... terbium-binding to bA3-crystallin range from 2.7 mm to 40 lm (Table 1). Thelow affinity might explain the nonsaturating natureof binding thermogram (Fig. 5B). Calcium is thuslikely to bind to bA3-crystallin...
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Tài liệu Báo cáo khoa học: Chemical approaches to mapping the function of post-translational modifications ppt
... common to organic synthesis but not yet amenable to proteinmodification. As new methodologies emerge, the studyof other PTMs and that of regulatory PTMs will hope-fully provide a powerful tool ... degree of branchingcooperate to regulate cell proliferation and differentia-tion. Cell 129, 123–134.16 Comstock LE & Kasper DL (2006) Bacterial glycans:key mediators of diverse host immune ... oligosaccharideassembly in the yeast Pichia pastoris: production ofcomplex humanized glycoproteins with terminal galac-tose. Glycobiology 14, 757–766.20 Hamilton SR, Bobrowicz P, Bobrowicz B, DavidsonRC,...
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Tài liệu Báo cáo khoa học: Peptides corresponding to helices 5 and 6 of Bax can independently form large lipid pores pdf
... storage compartments for anumber of pro-death proteins, such as cytochrome c,which are released into the cytoplasm as a consequenceof apoptotic signals. The release of these apoptoticfactors ... 2006 FEBScorresponding to Bid-a6, which has been shown previ-ously to be able to release calcein from PtdCho LUVs[28], assayed at L ⁄ P molar ratios up to % 5, wasunable to induce the release ... normally found soluble in the cytoplasm, itsapoptotic activation includes extensive structural reor-ganization, which facilitates targeting to, and insertioninto, the mitochondrial outer membrane...
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Tài liệu Báo cáo khoa học: From heart to mind The urotensin II system and its evolving neurophysiological role ppt
... receptor’s primary sequence shows stri-king similarities to the somatostatin receptor family,most notably in the transmembrane domains. Thepharmacological relatedness of somatostatin receptorsis ... laboratory from ratsshow only diffuse URP mRNA expression in certainareas of the medulla oblongata that are not known to project to the PPT. There will be a need to produceselective tools ... receptor was initially considered to only couple Gaqproteins, the receptor seems to beinvolved in an array of interactions with other signa-ling molecules whose full spectrum remains to bedetermined.Tissue...
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Tài liệu Báo cáo khoa học: Combinatorial approaches to protein stability and structure pdf
... difficult to purify and has a complex doublehydrophobic core (Fig. 4). The authors first sought to directly randomize the structural residues in TIM to estimate the overall tolerance to mutation. ... sequenceresemblance to each other or to proteins known in nature[69]. However, these proteins were not sufficiently soluble to be examined in vitro except as fusions to maltose bindingprotein ... long day), we want to be able both to understand what makes proteins ÔtickÕ andtoengineerproteins with native-like properties.In this review we discuss combinatorial approachestoward understanding...
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