báo cáo khoa học: " Staging of biliary atresia at diagnosis by molecular profiling of the liver" docx

... survival. Conclusions: Molecular profiling at diagnosis of biliary atresia uncovers a signature of inflammation or fibrosis in most livers. This signature may relate to staging of disease at diagnosis and ... that take into account the patient's biological makeup. Conclusions Gene expression profiling of the liver at the time of diag- nosis of bi...

Ngày tải lên: 11/08/2014, 12:20

... and the phos- phorylation state of their proteins, thereby changing the amount and localization of Bcl-2 family members. However, each type of cancer has its own way of disrupting the balance of ... ‘Bcl-2-regulated’) pathway [20]. The intrinsic pathway is characterized by the permeabili- zation of the outer mitochondrial membrane and the release of several pro-a...

Ngày tải lên: 16/02/2014, 09:20

... 2007) doi:10.1111/j.1742-4658.2007.06110.x Phosphorylation of the a-subunit of the eukaryotic initiation factor 2 (eIF2) on Ser51 is an early event associated with the down-regulation of protein synthesis at the level of translation and initiation ... translational factors regulating the initiation, elongation and termination of translation (reviewed in [1]). Translation...

Ngày tải lên: 07/03/2014, 05:20

... 2009. The patient’s sister had died of neck cancer at the age of 50 years. There wa s no history of malignanc ies in the patient’s mother, father or other first-degree relatives. Discussion The ... discussion of the manuscript; SS was supervisor of clinical management of the patient and interpretation of the data. All authors read and approved the final manuscr...

Ngày tải lên: 10/08/2014, 22:20

... with the presence of spore in the biliary system. These results enable us to conclude that the biliary tree is an adequate niche for the propagation of E. bieneusi. The contribution of the hosts ... volume of phenol/chloroform. 300 ul of supernatant was then added to 50 ul of 5M NaCl and the mixture incubated for 10 min at 65 o C. The solution was then extrac...

Ngày tải lên: 07/08/2014, 14:23

... investigated whether HSS could function as an MPT inhibitor, thereby alle- viating hepatic injury and promoting the survival of hepatocytes, after transfection of HSS into the cells or the administration ... [12], the assembly of the apoptosome. Upon formation of this complex, caspase-9 acquires the ability to trigger the processing and activation of the downstream c...

Ngày tải lên: 16/02/2014, 09:20

... concerning the size of the ion. Thus, the affinity of the different metal ions in MTs is governed primarily by the thermody- namic stability of the thiolate–metal bond. Therefore, soft metals ... discus- sion see below). The molecular basis of the air stability of the Cu(I) 4 cluster is not known. Cu(I)–thiolates are normally oxidized by molecular oxygen, re...

Ngày tải lên: 16/02/2014, 15:20

... (or dissociation of C). In the second phase, both variables evolve at similar rates towards their equilibrium values, corresponding to the consumption of substrate by the enzyme. The duration of the ... significantly, the former better approx- imates a SIM than the latter, as demonstrated by the trajectories approaching it. When the enzyme concen- tration exceeds...

Ngày tải lên: 18/02/2014, 06:20

... requires a complete MATH domain and the N-terminal region of RAP2.4 The use of a truncated version of BPM1 in the Y2H screens demonstrated that the BTB domain is not involved in the assembly with ... and in the anthers of dif- ferentiated flowers. We also detected meagre expres- sion along the root, with most obvious staining present at the lateral root primordia and...

Ngày tải lên: 18/02/2014, 06:20

... [21], they showed that the VEGFR-1 expressed in motor neurons mediates the neuroprotective effect of VEGF-B. In addition, the administration of VEGF-B was reported to increase the survival rate of ... vessels and their transfer to distant areas in the brain via blood flow; (b) the rapid migration of tumor cells outside blood vessels; and (c) the migration of tumor cells...

Ngày tải lên: 18/02/2014, 11:20