báo cáo khoa học: " The role of complex genomic alterations in neuroblastoma risk estimation" pot

... Because of the rare occurrence of neuroblastomas with- out any chromosomal alterations, the clinical outcome of these patients has so far remained elusive. Nevertheless, the routine application of ... Amplification of MYCN was confirmed to be a strong predictor of adverse outcome, but other single genomic alterations, such as loss of 11q or gain of 17q, were overr...

Ngày tải lên: 11/08/2014, 12:20

... antigen in itself [7,20]. At least for these antibodies, the role of the V L domain might be to increase the affinity by supporting the V H domain. The phenomenon may also be observed in the chain ... Although the Fv was designed based on HyHEL-10, it is not clear whether or not H39 is dominantly tuning the V H ⁄ V L interaction of other Fvs, including HyHEL-10. In...

Ngày tải lên: 07/03/2014, 12:20

... example, in the case of question Q209: “Who invented the paper clip ?”, the expected answer type is PERSON and so is the subject of the verb invented , lexicalized as the nominalization inventor. ... mountain; (b) lava IS-PART of vol- cano, and moreover it is a part coming from the inside; and (c) fragments of lava have all the prop- erties of lava, the following...

Ngày tải lên: 08/03/2014, 05:20

... that the increase of Glc6P in the presence of S4048 was caused by the inhibition of Glc6P hydro- lysis in the absence of detectable changes in glucose phosphorylation. S4048 causes inactivation of ... glu- cokinase and hexokinase I in distinct pools [3,24], or by the involvement of mechanisms, additional to Glc6P, in mediating the effects of glucokinase ove...

Ngày tải lên: 16/03/2014, 14:20

... tight binding affinity was demonstrated towards lauric acid, resulting in the synthesis of mainly x-1 hydroxylated lauric acid, suggesting a role in the lipid oxidative metabolism. Interestingly, the ... contain- ing the flavin cofactors FAD and FMN. It transfers the hydride ion of NADPH to the lower redox poten- tial FAD. FAD then transfers single electrons to FMN, which...

Ngày tải lên: 22/03/2014, 16:21

... Properties of the iron-binding site of the N-terminal lobe of human and bovine lactotransferrins. Importance of the glycan moiety and of the non–covalent interactions between the N- and C-terminal ... Archimedesweg, Leiden, the Netherlands Lactoferrin (LF) is an iron-binding glycoprotein of the innate host defence system. To elucidate the role of N-linked glyco...

Ngày tải lên: 30/03/2014, 13:20

... for the central role of ADAM10 and confirming that TACE has a minor role in the a-secretase cleavage of APP in human cells. During the course of the present study it was reported using an RNA interference ... cells in the absence or presence of APMA. Following this second incubation, the level of sAPPa in the medium was examined (Fig. 4A,B). There was no sig...

Ngày tải lên: 30/03/2014, 14:20

... however. Ins- tead the plants formed more stem units. The role of photoperiod and temperature in the induction and the release of dormancy in Pinus sylvestris L. seedlings I. ... (1985) Wintertime chan- ges in the fine structure and the ribosome content of the buds of Scots pine. In: Plant Production in the North. (Kaurin A.,...

Ngày tải lên: 09/08/2014, 02:21

... cancers. When the annual incidence of CRCs in 2005 was com- pared to that in 1999, there was an increase of 150% in men and 135% in women; CRC was shown to be one of the most sharply increased malignancies ... III rectal cancer [11], the role of adjuvant pelvic RT in rec- tal cancer with synchronous liver metastasis has not been defined. In this study, we investiga...

Ngày tải lên: 09/08/2014, 09:20

... rT 3 [4]. Cytokines can also contribute to the suppression of TSH. This raises an interesting question of whether the level of TSH, either in itself or in how it changes over the illness, has ... rekindled interest in the use of thyroid hormone therapy in critical illness. Continued improvements in survival after critical cardiac illness provokes the question of...

Ngày tải lên: 12/08/2014, 22:22