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báo cáo khoa học: " The role of complex genomic alterations in neuroblastoma risk estimation" pot

báo cáo khoa học:

báo cáo khoa học: " The role of complex genomic alterations in neuroblastoma risk estimation" pot

... Because of the rare occurrence of neuroblastomas with-out any chromosomal alterations, the clinical outcome of these patients has so far remained elusive. Nevertheless, the routine application of ... Amplification of MYCN was confirmed to be a strong predictor of adverse outcome, but other single genomic alterations, such as loss of 11q or gain of 17q, were overridden by the presence of any kind of ... prevalence of MYCN amplification and loss of 11q in unfavorable neuroblastoma, and the inverse correlation between these aberrations in high -risk neuroblastoma, it has been furthermore hypothesized...
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Báo cáo khoa học: The role of interface framework residues in determining antibody VH ⁄ VL interaction strength and antigen-binding affinity pptx

Báo cáo khoa học: The role of interface framework residues in determining antibody VH ⁄ VL interaction strength and antigen-binding affinity pptx

... antigen in itself [7,20]. Atleast for these antibodies, the role of the VLdomainmight be to increase the affinity by supporting the VHdomain. The phenomenon may also be observed in the chain ... Although the Fv was designed based on HyHEL-10, it is not clearwhether or not H39 is dominantly tuning the VH⁄ VLinteraction of other Fvs, including HyHEL-10. In addition, the effect of the H39 ... clarify the effect of the interface mutations on the antigen-binding affinity. To investigate systematically thisunsought relationship between the antigen-bindingaffinity of Fv and the VH⁄ VLinteraction...
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Báo cáo khoa học:

Báo cáo khoa học: "The Role of Lexico-Semantic Feedback in Open-Domain Textual Question-Answering" ppt

... example, in the case of questionQ209: “Who invented the paper clip ?”, the expected answer type is PERSON and so is the subject of the verb invented , lexicalized as the nominalization inventor. ... mountain; (b) lava IS-PART of vol-cano, and moreover it is a part coming from the inside; and (c) fragments of lava have all the prop-erties of lava, the following question semantic The Role of ... “Where did the ukulele originate ?”, the expected answer type isLOCATION. In the paragraph the ukulele intro-duced from Portugal into the Hawaiian islands”contains two named entities of the category...
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Báo cáo khoa học: The role of glucose 6-phosphate in mediating the effects of glucokinase overexpression on hepatic glucose metabolism pdf

Báo cáo khoa học: The role of glucose 6-phosphate in mediating the effects of glucokinase overexpression on hepatic glucose metabolism pdf

... that the increase of Glc6P in the presence of S4048 was caused by the inhibition of Glc6P hydro-lysis in the absence of detectable changes in glucosephosphorylation.S4048 causes inactivation of ... glu-cokinase and hexokinase I in distinct pools [3,24], orby the involvement of mechanisms, additional toGlc6P, in mediating the effects of glucokinase over-expression. As glucokinase binds ... control of glycolysis and glycogen synthesis by glucokinase overexpres-sion. The validity of S4048 for testing the role of Glc6P was supported byits lack of effect on glucokinase binding and...
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Báo cáo khoa học: The role of cytochrome P450 monooxygenases in microbial fatty acid metabolism pdf

Báo cáo khoa học: The role of cytochrome P450 monooxygenases in microbial fatty acid metabolism pdf

... tightbinding affinity was demonstrated towards lauric acid,resulting in the synthesis of mainly x-1 hydroxylatedlauric acid, suggesting a role in the lipid oxidativemetabolism. Interestingly, the ... contain-ing the flavin cofactors FAD and FMN. It transfers the hydride ion of NADPH to the lower redox poten-tial FAD. FAD then transfers single electrons toFMN, which in turn reduces the cytochrome ... occurring in the soil. Furthermore, branched chain fatty acids make up80% of the fatty acid content of the Bacillus sp. mem-branes and when the hydroxylation of these substrateswas studied in...
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Báo cáo khóa học: The role of N-linked glycosylation in the protection of human and bovine lactoferrin against tryptic proteolysis pdf

Báo cáo khóa học: The role of N-linked glycosylation in the protection of human and bovine lactoferrin against tryptic proteolysis pdf

... Properties of the iron-binding site of the N-terminal lobe of human and bovine lactotransferrins. Importance of the glycanmoiety and of the non–covalent interactions between the N- andC-terminal ... Archimedesweg, Leiden, the NetherlandsLactoferrin (LF) is an iron-binding glycoprotein of the innate host defence system. To elucidate the role of N-linkedglycosylation in protection of LF against proteolysis, ... such as the pancreaticenzyme trypsin has been suggested [19,20]. The experiments described herein further elucidate the role of N-linked glycosylation in the protection of lactofer-rin against...
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Báo cáo khoa học: The role of ADAM10 and ADAM17 in the ectodomain shedding of angiotensin converting enzyme and the amyloid precursor protein ppt

Báo cáo khoa học: The role of ADAM10 and ADAM17 in the ectodomain shedding of angiotensin converting enzyme and the amyloid precursor protein ppt

... for the central role of ADAM10 and confirming thatTACE has a minor role in the a-secretase cleavage of APP in human cells.During the course of the present study it was reportedusing an RNA interference ... cells in the absence or presence of APMA. Following this second incubation, the level of sAPPa in the medium was examined (Fig. 4A,B). There wasno significant difference in the level of sAPPa in the ... acid-basedmetalloprotease inhibitors [14] in the presence or absence of APMA. In the majority of cases there was little differencebetween the effect of inhibitors on the constitutive shedding of ACE and the APMA-induced...
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Báo cáo khoa học:

Báo cáo khoa học: "The role of photoperiod and temperature in the induction and the release of dormancy in Pinus sylvestris L. seedlings" potx

... however. Ins-tead the plants formed more stem units. The role of photoperiod and temperature in the inductionand the release of dormancy in Pinus sylvestris L. seedlingsI. ... (1985) Wintertime chan-ges in the fine structure and the ribosomecontent of the buds of Scots pine. In: PlantProduction in the North. (Kaurin A., Junttila O. &Nilsen ... role in the possibility of the buds to attain a deeper stage of dormancy. Only the 12 wk old plants of northern origin had no flushing buds after6 wk under growing conditions....
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Báo cáo khoa học:

Báo cáo khoa học: "The role of adjuvant pelvic radiotherapy in rectal cancer with synchronous liver metastasis: a retrospective study" doc

... cancers.When the annual incidence of CRCs in 2005 was com-pared to that in 1999, there was an increase of 150% in men and 135% in women; CRC was shown to be one of the most sharply increased malignancies ... IIIrectal cancer [11], the role of adjuvant pelvic RT in rec-tal cancer with synchronous liver metastasis has notbeen defined. In this study, we investigated the clinicalimplications of adjuvant pelvic ... Stone MD: The role of surgical resection of liver metastases in colorectal carcinoma. Seminars in oncology 1991, 18:399-406.3. August DA, Ottow RT, Sugarbaker PH: Clinical perspective of humancolorectal...
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Báo cáo khoa học:

Báo cáo khoa học: "The role of thyroid hormone therapy in acutely ill cardiac patients" pot

... rT3[4]. Cytokines can alsocontribute to the suppression of TSH. This raises aninteresting question of whether the level of TSH, either in itself or in how it changes over the illness, has ... rekindled interest in the use of thyroid hormone therapy in critical illness. Continued improvements in survival after critical cardiac illness provokes the question of whether thyroid hormone therapy ... is cytokine-mediated suppression of T3production. Cytokines, including IL-6, IL-1, and tumornecrosis factor-α, contribute to the suppression of the 5′deiodinase, thus shunting T4into rT3[4]....
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