báo cáo khoa học: " Investigation of post-transcriptional gene regulatory networks associated with autism spectrum disorders by microRNA expression profiling of lymphoblastoid cell lines" pps

... conditions underlying autism. Investigation of post-transcriptional gene regulatory networks associated with autism spectrum disorders by microRNA expression pro ling of lymphoblastoid cell linesTewarit ... post-transcriptional gene regulatory networks associated with autism spectrum disorders by microRNA expression pro ling of lymphoblastoid cell lines. Genome Medicine 2010, 2:23.Sarachana et ... Prediction of mammalian microRNA targets. Cell 2003, 115:787-798.doi:10.1186/gm144Cite this article as: Sarachana T, et al.: Investigation of post-transcriptional gene regulatory networks associated...

Báo cáo khoa học: Characterization of rat cathepsin E and mutants with changed active-site residues and lacking propeptides and N-glycosylation, expressed in human embryonic kidney 293T cells ppt

... phagosomeswithout perturbation of the formation of intracellularorganelles and without alteration of the morphology of vacuolar compartments, resulting in the profoundinhibition of the endosomal ... N-glycosylation of cathepsin E varies with cell type or its cellular localization. We thus ana-lyzed the nature of the oligosaccharide chains of ratcathepsin E in the transfected cells and then ... inhibited by the fungal metabolite brefeldin AABFig. 1. Immunoblot analysis of the cell extract of HEK-293T cellsexpressing wild-type cathepsin E. HEK-293T cells were transfected with rat cathepsin...

Báo cáo khoa học: "Analysis of clinical and dosimetric factors associated with severe acute radiation pneumonitis in patients with locally advanced non-small cell lung cancer treated with concurrent chemotherapy and intensity-modulated radiotherapy" pot

... occurred in 45% and 37% of patients with MLD of more than 15 Gy and NTCP of 50% or more, respectively,whereas it occurred in 0% of patients with a MLD of 10Gy or less and NTCP of less than 17%, respectively. ... factors associated with SARP. The incidences of SARP in the group with NTCP > 4.2% and NTCP ≤4.2% were 43.5% and 1.4%, respectively (p < 0.01). The incidences of SARP in the group with V10 ... cited.ResearchAnalysis of clinical and dosimetric factors associated with severe acute radiation pneumonitis in patients with locally advanced non-small cell lung cancer treated with concurrent chemotherapy...

Báo cáo khoa học: " Exclusion of elective nodal irradiation is associated with minimal elective nodal failure in non-small cell lung cancer" potx

... records of 115 patients with non-small cell lungcancer treated at our institution with definitive radiation therapy with or without concurrentchemotherapy (CHT). All patients were treated with ... toinvolved-field volumes without ENI [7]. Only 6.1% of Pattern of failureFigure 1Pattern of failure. A. Probability of any disease recurrence by Kaplan-Meier method. B. Pattern of Failure. Distant ... enhanced with the help of PET. The addition of PET to clinical mediastinal staging with CT has improved sensitivity and specificity com-pared with CT alone. More accurate clinical staging with PET...

Báo cáo khoa hoc:" Effect of venlafaxine on bone loss associated with ligature-induced periodontitis in Wistar rats" pptx

... inflam-matory cell infiltration with severe cementum destruction and alveolar process, C) periodontium of rat with EPD and treated with venlafaxine showing no evidence of prevention of inflammation ... Institutional Animal Ethics Committee of the Federal University of Ceará in accordance with theguidelines of the National Institute of Health, Bethesda.Induction of experimental periodontitis (EPD)Experimental ... medians with range within parenthesis, n = 5. * vs SO (p < 0.004 (Kruskal-Wallis and Dunn' tests).Figure 3 Histopathology of the periodontium of rats submitted to EPD and treated with...

báo cáo khoa học: " Characterization of WRKY co-regulatory networks in rice and Arabidopsis" ppsx

... WRKY genesbelonging to distinct phylogenetic groups (see Figure 4Co -regulatory networks of Arabidopsis WRKY genesFigure 4Co -regulatory networks of Arabidopsis WRKY genes. For each pair of WRKY ... The expression of the 104 OsWRKY genes was assessed in the following con-Phylogenetic tree of rice OsWRKY whole gene familyFigure 1Phylogenetic tree of rice OsWRKY whole gene family. Phylogenetic ... WRKY18,Additional file 12Co -regulatory networks of Arabidopsis WRKY genes. Co -regulatory networks of Arabidopsis WRKY genes obtained with the PCC threshold value of 0.7 in the untransformed...

Tài liệu Báo cáo khoa học: The splicing factor ASF/SF2 is associated with TIA-1-related/ TIA-1-containing ribonucleoproteic complexes and contributes to post-transcriptional repression of gene expression doc

... buffer.After 2 h of binding at 4 °C, beads were washed once with 1 mL of CBB and once with modiﬁed CBB (0.02% NP40).Elution of the bound proteins was performed by addition of 5 · 600 lL of calmodulin ... of red and green signals. (D) Overexpression of ASF ⁄ SF2 leads to SGassembly. COS cells were transiently transfected with high amounts of DNA (3 lg instead of 1 lg) encoding HA-ASF ⁄ SF2. Cells ... still becomes associated with TIAR inco-immunoprecipitation assays (Fig. S3). However,down-regulation of the ARE reporter mRNA by ASF ⁄ SF2 could not be abrogated by the expression of a RNA-binding...

Tài liệu Báo cáo khoa học: Induction of uPA gene expression by the blockage of E-cadherin via Src- and Shc-dependent Erk signaling docx

... that, in addi-tion to the loss of cell cell adhesion, involves degrada-tion of the extracellular matrix and release of cells fromthe constraints of cell cell and cell matrix interaction.MMPs ... the presence of asignal transduction pathway induced either directly by sE-cad or indirectly by the disruption of cell cell con-tact [55]. Here we show that disruption of cell cell con-tact ... the control of cell adhesion. Inhibition of Src catalytic activity by overexpression of dominant inhibitory c-Src or by spe-ciﬁc inhibitors stabilizes E-cadherin-dependent cell cell adhesion...

Báo cáo khoa học: Control of mammalian gene expression by amino acids, especially glutamine potx

... Analysis of gene expression in homocysteine-injured vascular endothelial cells: demonstration of GRP78/BiP expression, cloning and characterization of a novel reducing agent-tunicamycin regulated gene. Semin ... on ASS gene expression via a decrease in thenuclear amount of NF-jB [44]. This illustrates thatglutamine may regulate expression of the same gene via different pathways as a function of cell ... hepatoma cells,the transcriptional activity of the hepatocyte nuclearfactor-1 (HNF-1) decreased, limiting expression of thealbumin gene [38]. Another example is brought about by the activation of...

Báo cáo khoa học: Investigation of the contribution of histidine 119 to the conduction of protons through human Nox2 pptx

... wasused to generate a CHO cell line in which the expression of the m utated Nox2 was assessed. Nox2 was e xpressed in e ach of the C HO cell lines generated, however, the level of expression of H111/115L ... a number of different genomes [8].The generation of superoxide by the phagocytic NADPHoxidase is associated with an e fﬂux of protons [9]. The expression of wild-type Nox2 in CHO cells has ... followingtrypsinization [11]. Expression of the mutant Nox2 proteinsVeriﬁcation of the expression of each of the mutant Nox2proteins and determination of their cellular l ocalizationwere assessed by i mmunostaining...

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