báo cáo khoa học: " Inversion variants in the human genome: role in disease and genome architecture" ppsx

... domain binds to proteins containing the consensus sequence D ⁄ E FPPPPXD ⁄ E [21–23]. The Pro-rich domain also binds to profilin and proteins containing the SH3 and WW domains [17,24–26]. These ... that the EVH1, Pro-rich and EVH2 domains all have the potential to function in protein binding. The present study revealed that the EVH2 domain is the RAD51- binding domain....

Ngày tải lên: 23/03/2014, 04:20

... monomers. Human guanylate binding protein 5 (hGBP5) belongs to the family of interferon-c-induced p65 GTPases, which has seven members in the human genome [5]. This family of guanylate binding proteins ... members of the human guanylate-binding protein family. J Interferon Cytokine Res 27, 44–52. 15 Rupper AC & Cardelli JA (2008) Induction of guanylate binding protein 5 by...

Ngày tải lên: 15/03/2014, 10:20

... Distribution of inversion variants in the human genome. The blue lines in this ideogram show the human chromosomal distribution of the 479 non-redundant inversion variants reported in the Database ... step towards a deeper understanding of human variation and genome dynamics. © 2010 BioMed Central Ltd Inversion variants in the human genome: ro...

Ngày tải lên: 11/08/2014, 12:20

... the chagasin molecule is slanting towards the R domain. The angle of approach of cystatin B is )12.7°, and the inhibitor molecule is inclined towards the L domain of the enzyme. The difference in the ... are interpreted as further improving the binding efficiency to papain and cathep- sin L versus the other enzymes, with the hydrogen bond between D99 in loop L6 of...

Ngày tải lên: 16/03/2014, 04:20

... interactions between the subunits and are involved in cofactor binding, substrate binding and catalysis (Fig. 1). On the other hand, the mutations did not affect either the capability to bind the cofactor or the ... in orange, the oxygen atoms in red and the nitrogen atoms in blue. The helices forming the third cluster interact with the N-ter- minal helix o...

Ngày tải lên: 30/03/2014, 02:20

... the LPCAT activity (data not shown). The stimulation of LPCAT by IFN-c could be inhibited by the tyrosine kinase inhibitor tyrphostin (2.5 l M ) but not by the protein kinase C inhibitor bisindolylmalamide ... LPS; inhibition of this enzyme almost completely inhibited LPS-induced TNF-a protein and mRNA production suggesting a role for LPCAT in the LPS-induced signaling pathway...

Ngày tải lên: 31/03/2014, 01:20

... LIP. The increase in ferritin by the iron preparations showed a pattern of behavior similar to the increase of the LIP. The more iron appeared in the LIP the faster the synthesis of ferritin took ... from the LIP is not stored in existing ferritin but is incorporated into newly synthesized ferritin. Compared to the increase in ferritin expression, the total amoun...

Ngày tải lên: 31/03/2014, 07:20

... 1. Histochemical staining of DBA (A and B), SBA (C and D), and Isolectin B4 (E and F) in the vomeronasal sensory epithelium of the horse. The DBA (A and B), SBA (C and D), and Isolectin B4 (E and F) lectins ... Characterization of the Lectin-binding Sites in the Equine Vomeronasal Organ 17 Discussion This is the first study to examine the binding of DBA, SBA,...

Ngày tải lên: 07/08/2014, 17:22

... class="bi x0 y1 w2 h 2" alt =""

Ngày tải lên: 07/08/2014, 18:21

... cm in diameter concerning the right occipital, parietal and temporal bones and protruding from the right occipital bone (Figs. 1A and B). The mass severely compressed the cerebellum and the ... lobe (Figs. 1C and D) but did not appear to invade the brain tissue, the meninges or other neighbouring tissues. The mass was whitish to yellow and gritty on the cu...

Ngày tải lên: 07/08/2014, 23:22