báo cáo khoa học: " Musings on genome medicine: Crohn’s disease" potx

... the eye’. At present the general consensus regarding the etiology of both CD and UC is that they are the result of very Musings Musings on genome medicine: Crohn’s disease David G Nathan and ... of chronic stimulation of cytokine production and T cell activation to others. When CD is active, it is usually associated with microcytic anemia, the so-called ‘anemia of inflammation’...

Ngày tải lên: 11/08/2014, 12:20

... Morone [5]. Their fine book demonstrates that all of the proposals emanating from the gaseous environment on Capital Hill have been considered over and over again in previous adminis trations. ... 94.2 http://genomemedicine.com/content/1/10/94 Nathan and Orkin: Genome Medicine 2009, 1:94 vast disruption of civilian life created a need for national health services in order ... militar...

Ngày tải lên: 11/08/2014, 12:20

... Science. London: BioMed Central; 2001. 2. Nathan DG, Orkin SH: Musings on genome medicine: gene therapy. Genome Med 2009, 1:38. 3. Johnson FL, Thomas ED: Treatment of relapsed acute lym- phoblastic ... glycosamino- glycans and the consequent accumulation of heparan sulfate and dermatan sulfate throughout the body. The disorder is caused by mutations in alpha-l-iduronidase, but t...

Ngày tải lên: 11/08/2014, 12:20

... and Orkin Genome Medicine 2010, 2:4 http://genomemedicine.com/content/2/1/4 doi:10.1186/gm125 Cite this article as: Nathan DG, Orkin SH: Musings on genome medicine: Hepatitis C. Genome Medicine ... encodes interferon lambda 3 predicts both spontaneous clearance of HCV and response to interferon and ribavirin treatment in geno- type 1 hepatitis C infection. Clearance and respon...

Ngày tải lên: 11/08/2014, 12:20

... deletion mutation showed reduced fluorescence. The single aspartate mutations showed a concomitant reduction in Ab secretion, whereas the D257A/D385A and DE9 mutations had no effect on Ab secretion. Keywords: ... molar concentrations for splice-overlap PCR and cloned into pCDNA3.1+ (Invitrogen) or into pIRESpuro2 (Clontech) to enable the control of gene transcription by adjusting the concentr...

Ngày tải lên: 08/03/2014, 08:20

... from similar constructions. The next consideration, and the subject of the present section, is how the construction should be situated within the generation process: what decisions, made at ... level adjunct (RatC). 3. GENERATING THE CONSTRUCTIONS To analyse a construction for generation, we must consider what it means, or, put another way, consider why a speaker would choose to use...

Ngày tải lên: 24/03/2014, 02:20

... parkinsonism of early onset and are the focus of this minireview. Keywords cell death; DJ-1; HtrA2; mitochondria; mutation; neuron; Parkin; Parkinson’s disease; PINK1; signalling Correspondence H. ... (1979) Chronic parkin- sonism secondary to intravenous injection of meperidine analogues. Psychiat Res 1, 249–254. 38 Langston WJ, Ballard P, Tetrus JW & Irwin I (1983) Chronic parkinsonism...

Ngày tải lên: 18/02/2014, 14:20

... specific, connection to ceramide metabolism. Neurodegeneration with brain iron accumulation-2 (NBIA-2) is characterized by the disruption of cellular mechanisms leading to the accumulation of iron in ... Gene Expression Unit, National Institutes on Aging, Bethesda, MD, USA 4 Department of Molecular Neuroscience, Institute of Neurology, University College London, UK 5 Reta Lila Weston Institu...

Ngày tải lên: 18/02/2014, 14:20

... proportion of oxidized iron after adding DA or these TIQs at a con- centration equimolar to the hTH subunit concentration (220 ± 7.5 lm). Equimolar DA concentrations led to the generation of 80% ... solvation contribution (kcalÆmol )1 ) 309.58 145.36 218.51 157.65 123.67 85.06 Nonpolar solvation contribution (kcalÆmol )1 ) )2.99 )2.46 )2.3 )2.6 )2.44 )3.09 Intramolecular contribution (kcalÆmo...

Ngày tải lên: 07/03/2014, 05:20

... early-onset PD cases. A heterozygous duplication involving the first five exons of DJ-1 in a single patient is the only other CNV published so far [15]. Genome- wide association studies Genome- wide ... Chr4 Toft and Ross Genome Medicine 2010, 2:62 http://genomemedicine.com/content/2/9/62 Page 2 of 4 Copy number variation Traditional cytogenetic approaches first showed that variations in...

Ngày tải lên: 11/08/2014, 12:20