báo cáo khoa học: " Functional genomic and epidemiological studies reveal novel genes regulating cholesterol metabolism" doc

... between Minireview Functional genomic and epidemiological studies reveal novel genes regulating cholesterol metabolism Kris Richardson and Jose M Ordovas Address: Nutrition and Genomics Laboratory, ... review recent functional genomic research that, combined with results from genome- wide association studies, provides a powerful tool to identify novel candidate...

Ngày tải lên: 11/08/2014, 12:20

... site-directed mutagenesis of FHT [7,9] and by documentation of ligand binding in crystalline DAOCS and IPNS complexes [23–25]. The coordination of Fe II is commonly mediated by two histidine and one aspartate ... 12) was negligible and the band could be hardly recognized in the soluble Gly68fiPro and Gly261fiPro mutant extracts (lanes 9 and 11). Table 2. Specific activities of the wi...

Ngày tải lên: 21/02/2014, 03:20

... 2-oxidoreductase genes (Eur. J. Biochem. 270) 1569 Functional expression of the quinoline 2-oxidoreductase genes ( qorMSL )in Pseudomonas putida KT2440 pUF1 and in P. putida 86-1 D qor pUF1 and analysis ... lgÆmL )1 )wasaddedtotherespectivemedium. DNA techniques Standard recombinant DNA techniques were used for DNA isolation [38,39] and restriction, agarose gel electro- phoresis...

Ngày tải lên: 17/03/2014, 10:20

... identity. Uptake studies in RSO membranes containing the transporters revealed transport of citrate in complex with Ca 2+ ,Sr 2+ ,Mn 2+ ,Cd 2+ and Pb 2+ and not with Mg 2+ ,Zn 2+ ,Ni 2+ and Co 2+ . ... of E. faecalis and S. mutans are similar, but not the same. Upstream of the citDEF genes coding for the a, b and c subunits of citrate lyase are the oadDB genes coding for the d...

Ngày tải lên: 23/03/2014, 10:20

... lidocaine HCl (Dai Han Pharm, Korea) at 2 mg/kg/h and ketamine HCl (Yuhan Pharm, Korea) at 0.3 mg/kg/h [26]. After the operation, dogs were bandaged, monitored in the intensive care unit and ... ASC group (circles). G and H: These showed structural consistency with nerve cell. A, B and C: H&E stain, D-G: Luxol fast blue and cresy l violet stain, H, H1, H2 and H3: Immunoflu...

Ngày tải lên: 07/08/2014, 23:22

... gone and where we might go in the use of systems biology and functional genomics to understand RA must be informed by the rich and exciting wellspring of data emerging from model organisms and ... suspected, based on twin studies, studies of specific gene loci (such as the human leukocyte antigen (HLA) locus), and, more recently, gene linkage and genome-wide association...

Ngày tải lên: 11/08/2014, 12:20

... presence of the mutation and showed that no other changes were present. Expression and purification of bsSHMT and E53QbsSHMT The expression and purification of the wild-type (bsSHMT) and the mutant enzymes ... l-allo-Thr and Gly and FTHF were crystallized using the same condition with 10 mm of the specified ligand. These procedures were identical to those used for the crystallizati...

Ngày tải lên: 18/02/2014, 16:20

... the other hand, compounds 1, 4 , and 5 are non- competitive inhibitors, and compounds 2 and 3 are competitive inhibitors with respect to NADP. Table 2 summarizes the IC 50 values and kinetic ... bacter- ial genomics has provided investigators with powerful tools to identify novel antibacterial targets [8,9]. At the same time, comparison of bacterial target genes with human genes...

Ngày tải lên: 19/02/2014, 05:20

... SNoW (Li and Roth, 2005), where questions are encoded us- ing various lexical, syntactic and semantic features. The retrieval and answer extraction phases consist in retrieving relevant documents ... the BOW and PT features on answer classification Figure 5: Impact of the PAS and PASN features combined with the BOW and PT features on answer classification Figure 6: Comparison betwee...

Ngày tải lên: 20/02/2014, 12:20

... the TDL (Krieger and Sch¨afer, 1994) and ALE (Car- penter and Penn, 1996) systems, and has earlier an- tecedents in work that applied lexical rules by sub- sumption (Krieger and Nerbone, 1991). ... trigger(φ 1 )trigger(φ 2 ), and • trigger (φ 1 ∨φ 2 ) = trigger(φ 1 )trigger(φ 2 ), where  and  are respectively unification and gen- eralization in the type semi-lattice. In thi...

Ngày tải lên: 20/02/2014, 15:21