báo cáo khoa học: " Functional genomic and epidemiological studies reveal novel genes regulating cholesterol metabolism" doc
báo cáo khoa học: " Functional genomic and epidemiological studies reveal novel genes regulating cholesterol metabolism" doc
... between Minireview Functional genomic and epidemiological studies reveal novel genes regulating cholesterol metabolismKris Richardson and Jose M OrdovasAddress: Nutrition and Genomics Laboratory, ... review recent functional genomic research that, combined with results from genome-wide association studies, provides a powerful tool to identify novel candidate genes relevant to cholesterol ... plasma LDL cholesterol levels [3].The gaps in our understanding of cholesterol metabolismGiven the importance of cholesterol homeostasis in the prevention of CVD, it is crucial to understand the...
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Tài liệu Báo cáo khoa học: Functional expression and mutational analysis of flavonol synthase from Citrus unshiu pptx
... site-directed mutagenesis ofFHT [7,9] and by documentation of ligand binding incrystalline DAOCS and IPNS complexes [23–25]. Thecoordination of FeIIis commonly mediated by two histidine and one aspartate ... 12) was negligible and the band couldbe hardly recognized in the soluble Gly68fiPro and Gly261fiPromutant extracts (lanes 9 and 11).Table 2. Specific activities of the wild-type and the Gly68fiAla, ... [26],although this enzyme has not been functionally proved and the lability of substrate and product rule out any cocrys-tallization. The setting of a helices and b-strands causes verysimilar CD spectra...
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Báo cáo khoa học: Functional expression of the quinoline 2-oxidoreductase genes (qorMSL) in Pseudomonas putida KT2440 pUF1 and in P. putida 86-1 Dqor pUF1 and analysis of the Qor proteins doc
... 2-oxidoreductase genes (Eur. J. Biochem. 270) 1569 Functional expression of the quinoline 2-oxidoreductase genes (qorMSL)inPseudomonas putidaKT2440 pUF1 and inP. putida86-1DqorpUF1 and analysis ... lgÆmL)1)wasaddedtotherespectivemedium.DNA techniquesStandard recombinant DNA techniques were used forDNA isolation [38,39] and restriction, agarose gel electro-phoresis and cloning [38]. Random digoxigenin labelling ... constructs, pBG2a and pBG2b (nptII in the same and in the opposite orientation with respect to the deletedqor genes, respectively). E. coli XL-1 Blue MRF¢ was usedas host strain for pBG2a and pBG2b....
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Báo cáo khoa học: Functional characterization and Me2+ ion specificity of a Ca2+–citrate transporter from Enterococcus faecalis1 pdf
... identity.Uptake studies in RSO membranes containing thetransporters revealed transport of citrate in complexwith Ca2+,Sr2+,Mn2+,Cd2+ and Pb2+ and not withMg2+,Zn2+,Ni2+ and Co2+. ... of E. faecalis and S. mutansare similar, but not the same. Upstream of the citDEF genes coding for the a, b and c subunits of citrate lyaseare the oadDB genes coding for the d and b subunitsCa ... EDTA and bivalent metal ions, which corresponded to139.3 ± 20.6 and 15.9 ± 1.8 pmolÆ(mg protein))1for the control and EfCitH-expressing membranes, respectively. Error bars represent thestandard...
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Báo cáo khoa học: "Functional recovery and neural differentiation after transplantation of allogenic adipose-derived stem cells in a canine model of acute spinal cord injury" potx
... lidocaine HCl (Dai Han Pharm, Korea) at 2 mg/kg/h and ketamine HCl (Yuhan Pharm, Korea) at 0.3 mg/kg/h [26]. After the operation, dogs were bandaged, monitored in the intensive care unit and ... ASCgroup (circles). G and H: These showed structural consistency with nerve cell. A, B and C: H&E stain, D-G: Luxol fast blue and cresylviolet stain, H, H1, H2 and H3: Immunofluorescence ... over 12 h. Severe hemorrhage and vacuolar formation occurred 1 week after SCI and generalized infiltration of fibrous tissue was seen 9 weeks post-injury and no functional improvement in control...
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báo cáo khoa học: " Functional genomics and rheumatoid arthritis: where have we been and where should we go?" pdf
... gone and where we might go in the use of systems biology and functional genomics to understand RA must be informed by the rich and exciting wellspring of data emerging from model organisms and ... suspected, based on twin studies, studies of specific gene loci (such as the human leukocyte antigen (HLA) locus), and, more recently, gene linkage and genome-wide association studies [2,3]. Patients ... synovium and found evidence for adaptive immune responses in some patients with RA, and fibroblast anomalies in others. A year later, Abstract Studies in model organisms and humans have begun to reveal...
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Tài liệu Báo cáo khoa học: Structure determination and biochemical studies on Bacillus stearothermophilus E53Q serine hydroxymethyltransferase and its complexes provide insights on function and enzyme memory doc
... presence of the mutation and showed that no other changes were present.Expression and purification of bsSHMT and E53QbsSHMTThe expression and purification of the wild-type (bsSHMT) and the mutant enzymes ... l-allo-Thr and Gly and FTHF were crystallized using the same conditionwith 10 mm of the specified ligand. These procedures wereidentical to those used for the crystallization of bsSHMT and its ... Both bsSHMT and E53QbsSHMT ter-nary complexes were dialyzed against buffer (50 mmpotassium phosphate pH 7.4 containing 1 mm EDTA and 1 mm 2-mercaptoethanol) devoid of Gly and FTHF and spectra...
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Tài liệu Báo cáo khoa học: Biochemical characterization and inhibitor discovery of shikimate dehydrogenase from Helicobacter pylori docx
... the other hand, compounds 1, 4 , and 5 are non-competitive inhibitors, and compounds 2 and 3 arecompetitive inhibitors with respect to NADP. Table 2summarizes the IC50values and kinetic ... bacter-ial genomics has provided investigators with powerfultools to identify novel antibacterial targets [8,9]. At thesame time, comparison of bacterial target genes withhuman genes will ... Pisum sativum and Nicoti-ana tabacum, SDH is associated with 3-dehydroquinatedehydratase to form bifunctional enzyme [18,19]. Infungi and yeast, such as Aspergillus nidulans and Sac-charomyces...
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Tài liệu Báo cáo khoa học: "Exploiting Syntactic and Shallow Semantic Kernels for Question/Answer Classification" docx
... SNoW (Li and Roth, 2005), where questions are encoded us-ing various lexical, syntactic and semantic features.The retrieval and answer extraction phases consist inretrieving relevant documents ... the BOW and PT features onanswer classificationFigure 5: Impact of the PAS and PASN featurescombined with the BOW and PT features on answerclassificationFigure 6: Comparison between PAS and PASNwhen ... convolution kernels for depen-dency and constituent syntactic trees. In ECML’06.S. Quarteroni and S. Manandhar. 2006. User modelling forAdaptive Question Answering and Information Retrieval. InFLAIRS’06.E....
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Tài liệu Báo cáo khoa học: "Balancing Clarity and Efficiency in Typed Feature Logic through Delaying" docx
... theTDL (Krieger and Sch¨afer, 1994) and ALE (Car-penter and Penn, 1996) systems, and has earlier an-tecedents in work that applied lexical rules by sub-sumption (Krieger and Nerbone, 1991). ... trigger(φ1)trigger(φ2), and • trigger (φ1∨φ2) = trigger(φ1)trigger(φ2),where and are respectively unification and gen-eralization in the type semi-lattice.In this and the next two subsections, ... constraint enforcement and relationalgoal resolution, delaying takes between three and five times more of the percentage of sentence parse2The author sincerely thanks Kordula DeKuthy and Det-mar Meurers...
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