The Fetal Matrix: Evolution, Development and Disease - part 1 ppt
The Fetal Matrix: Evolution, Development and Disease - part 1 ppt
... University Press The Edinburgh Building, Cambridge CB2 8RU, UK First published in print format ISBN -1 3 97 8-0 -5 2 1- 8 345 7-5 ISBN -1 3 97 8-0 -5 2 1- 5 423 5-7 ISBN -1 3 97 8-0 - 51 1- 3 370 1- 7 © P. Gluckman and M. Hanson ... without the written p ermission of Cambrid g e University Press. ISBN -1 0 0-5 1 1- 3 370 1- 9 ISBN -1 0 0-5 2 1- 8 345 7...
Ngày tải lên: 11/08/2014, 11:22
The Fetal Matrix: Evolution, Development and Disease - part 7 ppt
... only in the offspring but also in the grand-offspring. We have already told the story of the Dutch Hunger Winterof1944/5 andexactly thesamething happenedthere :the grandchildrenborn to mothers who ... the paternal grandparent to the risk of diabetes in the grandson. Interestingly, the effect seemed to be confined to nutrition during the grandfather’s pre-pubertal growth phas...
Ngày tải lên: 11/08/2014, 11:22
The Fetal Matrix: Evolution, Development and Disease - part 2 ppsx
... conception, the interests of the mother and her fetus 11 are not always aligned. The fetus and mother are not genetically identical because the fetal genome is an admixture of maternal and paternal ... on the fetus but also on the placenta, and this may play a part in the development of the disease pre-eclampsia. The crucial point is that for about the fir...
Ngày tải lên: 11/08/2014, 11:22
The Fetal Matrix: Evolution, Development and Disease - part 3 pps
... the Netherlands exposed to the near- famine conditions imposed by the Nazis in the winter of 19 44/45. The effects of the poor and unbalanced diet of women during pregnancy on their children and ... For exampleiftherehasbeenafailureofsuppressionofoneofthetwocopies of the IGF-2 gene by imprinting the maternal copy, then the fetus expresses twice the normal amount of IG...
Ngày tải lên: 11/08/2014, 11:22
The Fetal Matrix: Evolution, Development and Disease - part 4 ppsx
... 000 10 000 0 18 20 18 40 18 60 18 80 19 00 No. of lynx pelts Year Fig. 3.3 Graph showing the number of lynx-fur pelts returned from the Northern Department of the Hudson Bay Company from 18 21 to 19 10. ... Predictive adaptive responses and human disease Coronary heart disease Standardised mortality ratios (SMR) in 10 14 1 men and 5585 women 20 40 60 80 10 0 12 0...
Ngày tải lên: 11/08/2014, 11:22
The Fetal Matrix: Evolution, Development and Disease - part 5 potx
... from the mitochondria in the egg, and not via the sperm. So they fit the bill of DNA that is transmitted directly from grandmother to granddaughter. Second, the metabolic capacity of the grandchildren’s ... effect. The telling example was the so-called Dutch Hunger Winter of 19 44/45 which we referred to in chapter 2. In November 19 44 the Nazi occupiers of Holland had 1...
Ngày tải lên: 11/08/2014, 11:22
The Fetal Matrix: Evolution, Development and Disease - part 8 pot
... different nature 7 And the argument can continue back with diminishing effect to the great-grandmaternal and great-great- grandmaternal environments and so on. 8 The ovary develops in the first half ... appropriately balances the nutritional needs of mother and fetus. But if the mother has a diabetic 19 1 The prenatal origin of inappropriate PARs the ravages of the e...
Ngày tải lên: 11/08/2014, 11:22
The Fetal Matrix: Evolution, Development and Disease - part 9 doc
... devel- opment and recorded his findings. From his observations, he recognised that the health of the fetus and the subsequent child depended on the health of the mother. Two -and- a-half thousand ... Engl. J. Med. 284 (19 71) , 878– 81. 210 Fetal futures understand about the scope of these changes, of the environmental cues and the impact on cell growth and differe...
Ngày tải lên: 11/08/2014, 11:22
The Fetal Matrix: Evolution, Development and Disease - part 10 doc
... 20 dimensions 15 0 diversity 15 0 eye 12 0, 12 0n hominids 15 9, 17 4 humans 17 3–5, 17 7n, 18 8–9, 19 0 1 attenuation 17 3 PARs 16 1–2, 16 7–72, 206–8 selection 14 9–52 success 16 7 survival phenotype 11 9 time 15 0 exercise altered ... interventions 211 old age 19 0 1 origins xii PAR-related 19 1, 208–9 prevention 211 12 pattern analysis 19 7–8 phenotype 18 risk 1...
Ngày tải lên: 11/08/2014, 11:22
The Materials Science of Coatings and Substrates Part 1 ppt
... Hours 1m -1 1 00 14 5,OOO -1 6 0,ooO 19 0-2 20 Minimum 8 11 0 1- 1 200 16 0,00 0- 17 4,000 19 0-2 20 Minimum 10 12 0 1- 1 300 17 4,OOO-l89,oOO 19 0-2 20 Minimum 12 13 01 -1 400 1 89,OOO-203,OOO 19 0-2 20 ... 14 14 0 1- 1 500 203,OOO- 218 ,ooO 19 0-2 20 Minimum 16 15 01 -1 600 218 ,00 0-2 32,000 19 0-2 20 Minimum 18 16 0 1- 1 700...
Ngày tải lên: 10/08/2014, 12:21