báo cáo khoa học: " Uncharacterized conserved motifs outside the HD-Zip domain in HD-Zip subfamily I transcription factors; a potential source of functional diversity" docx

... two are almost indispensable: a DNA-binding domain and a protein-proteininteractiondomainwhich mediates activation or repression of transcription [1]. HD-Zip proteins are transcription factors ... proteins have a mod- ular structure and exhibit at least two types of domains: a DNA binding domain and a protein-protein interaction domain which mediates, directly or ind...

Ngày tải lên: 11/08/2014, 11:21

... brain. In the course of cerebral ischemia (i. e. stroke, trauma, cardiac arrest), abnormal levels of the excitatory amino acid glutamate build up in the brain, causing ‘axon-sparing’ excitotoxic ... University of Calabria, Arcavacata di Rende (CS), Italy A wealth of information has accumulated to date con- cerning the basic mechanisms underlying post-ischemic neuronal de...

Ngày tải lên: 07/03/2014, 03:20

... polyglutamine tract [28]. Ataxin-1 inclusion formation is dictated by signaling and post-translational phosphorylation of a single serine in ataxin-1 at position 776, regardless of poly- glutamine ... Disease Foundation, (HDF) USA, the Cure Huntington’s Disease Initiative (CHDI) USA, the Huntington’s disease Society of America (HDSA), the Huntington’s Society of Canada and...

Ngày tải lên: 23/03/2014, 07:20

... function. There is now evidence that in an increasing number of specific cases this not only involves targeting signals within proteins, but also signals in mRNAs resulting in their localization and ... The data indicate a novel func- tional role for the RNA-binding properties of annexin A2 in perinuclear localization of mRNA and the association with the cytoskeleton....

Ngày tải lên: 30/03/2014, 15:20

... Gammamed1 2i high-dose- rate afterloading machine (Varian Medical Systems, Haan, Germany) with a Ir-192 source and a nominal activity of 10 Ci which was situated in a special room in direct vicin- ity ... primary sarcomas, in the remaining nine the disease had recurred. The mean age at the beginning of treatment was 56 years, the mean Karnofsky performance status 9...

Ngày tải lên: 09/08/2014, 10:20

... dis- cussions: Interviewe r: ‘What do you think in general about promoting things such as new guideline therapies through patient-initiated interventions taking infor- mation to the patient and having them bring ... intervention as facilitating change in a manner more unique to patient activation, by ‘empowering’ patients and ‘align- ing’ the ‘priorities’ of the patient and prov...

Ngày tải lên: 10/08/2014, 10:22

... that maximum bite force in the molar area was not associated with facial characteristics in Scandinavian children and young adults, although they found that bite force in the incisor region was ... image was cali- brated with the digital calipers image (10 mm-width). Intermolar distance was measured in triplicate for each image and averaged. MMF in maximum opening was calculat...

Ngày tải lên: 11/08/2014, 23:22

... intracellu- lar loop, and two intracellular tails (the C and N-termi- nus). Within the family of mammalian claudins the N- terminal is ~7 amino acids, the first extracellular loop (ECL1) is ~50 amino acids, ... author of this manuscript. Author information After finishing high school in Tucson, Arizona, the author enlisted as an infantryman in the United States Army. After...

Ngày tải lên: 12/08/2014, 04:21

... DISCUSSION Identi®cation of two A subunit-binding domains in B5 6a To determine the minimal r egion of B56 that interacted with the PP 2A subunit, we utilized an in vitro binding assay using GST -A subunit ... in the individual protein sequence, followed by the GenBank accession number. Amino acids that are invariant are highlighted in black. Identical residues conse...

Ngày tải lên: 08/03/2014, 10:20