báo cáo khoa học: "Role of TRIPTYCHON in trichome patterning in Arabidopsis" pptx

... expression pattern in pTRY-A3, B and pTRY-A3 at different time points of GUS staining proced ure (data not shown). We observed that the GUS staining in young trichomes became detectable in both lines after ... could in principle be due to various aspects including the protein stability, protein move- ment and their interaction with other proteins, in parti- cular the bHLH factors....

Ngày tải lên: 11/08/2014, 11:21

... tyrosinase 320 amino acids Core domain 36–357 Copper binding motif Arg40 Cys84 Tyr349 Tyr347 Copper binding motif Trypsinisedpro-tyrosinase 332 amino acids Core domain 36–370 Copper binding ... motif Arg40 Cys84 Tyr349 Tyr347 Lys370 Ala36 Ala36 Ala36 Val357 Phe518 B Laccase Tyrosinase β -sheet protein Fig. 1. Overview of the tyrosinase gene and surrounding genes in the genome of...

Ngày tải lên: 06/03/2014, 11:20

... monolayer primary cultures of bovine thyroid cells, maintained in the presence of insulin, produced a cytosolic inhibitor of TPO activity. Its molecular mass of less than 2 kDa coincides with that reported ... decrease of thyroid hormone biosynthesis in primary cultures in the presence of insulin. In addition, our data suggest that insulin stimulates cell division, in bo...

Ngày tải lên: 30/03/2014, 14:20

... shown that interactions between KCs and endotoxin comprise the initiating event lead- ing to hepatotoxicity in liver injury, including endotox- emia and ischemia ⁄ reperfusion injury [14]. In our studies, ... signaling is independent of Toll-interleukin 1 receptor domain-containing adaptor protein. Drug Metab Dispos 36, 95–101. 10 Ghose R, Guo T & Haque N (2009) Regulation of gene...

Ngày tải lên: 14/02/2014, 18:20

... have indi- cated that the CagA PY -induced cell elongation pheno- type also involves tyrosine dephosphorylation of cortactin, vinculin and ezrin, which are three well- known actin-binding proteins ... revealed the involvement of ADAM17, a metalloprotease involved in catalyzing ectodomain shedding of RTK ligands. In nonstimulated cells, ADAM17 is normally in complex with the integr...

Ngày tải lên: 14/02/2014, 19:20

... role in skin wound healing. After a skin injury, PPARb expression is rap- idly elevated in the epidermis at the wound edges; dele- tion of a single PPARb allele results in delayed wound healing ... cultured human keratinocytes [14]. In this study, we examined the interaction between CerK and PPARb, and its role in regulating keratino- cyte survival. We report that in a mouse ker...

Ngày tải lên: 18/02/2014, 18:20

... action of cholera toxin in rat liver parenchyma. Following administration of a saturating dose of cholera toxin to rats, rapid endocytosis of both cholera toxin subunits was observed, coincident ... effects by increasing cAMP levels [1]. The resulting increase in intracellular cAMP causes net intestinal salt and water secretion, resulting in massive secretory diarrhea and change...

Ngày tải lên: 19/02/2014, 02:20

... MAP kinase signaling pathway. TAM67 retains the DNA binding and leucine-zipper region of c-Jun, but it lacks the transactivation domain of c-Jun (amino acids 1–122). It thus blocks the bind- ing of ... event in determining the susceptibility to apoptosis through maintaining the integrity of the mitochondria and inhibiting activation of the caspase cascade [37]. High expression lev...

Ngày tải lên: 19/02/2014, 06:20

... fosfomycin binding due to charge–charge repulsions. Most interestingly, the uncharged valine side chain completely abolishes fosfomycin binding in the absence of UDPNAG. Clearly, UDPNAG binding creates additional ... not interact with R124 in the ternary complex [20]. Hence, the mechanism of binding of fosfomycin by reinforcement of an initial binding site (mainly K22 and R397) th...

Ngày tải lên: 19/02/2014, 13:20

... on conformation of inhibitor main chain. Thus, different inhibitors differ not only in t he binding affinity, bu t a lso in the degree o f freedom of the inhibitor inside the binding tunnel. Some s pecial inhibitors ... Phe53 rings are in both o rientations stacked by p–p interaction with Phe153 rings of the neighbouring protein dimer in crystal. The alternative positions of ph...

Ngày tải lên: 19/02/2014, 16:20