... degree of overlap. Careful experimentation to test those hypotheses will need to be performed to determine the binding characteristics of the nucleic acid substrates, both alone and in the presence ... seems reasonable to make the working hypothesis that the RNA and DNA binding sites are not the same, rather that they are separate. This does not exclude the pos...
Ngày tải lên: 17/03/2014, 10:20
... decrease of the pH in the peri- apical tissues, and thus there are special demands for the sealing agent s [31]. The major task in reducing the bacterial load, concentrated in the apical region of the root ... have lead to higher treatment success rates, endodontic treatment and the subsequent restoration of the tooth should be considered as a ther- apy superior...
Ngày tải lên: 11/08/2014, 20:21
báo cáo khoa học: " Mass spectrometry analysis of the variants of histone H3 and H4 of soybean and their post-translational modifications" pps
... and H4.2), which varied at the amino acid residue I 60 of histone H4.1 and V 60 of histone H4.2 (Figure 11). The trypsin digested peptides of histone H4 were directly applied to MALDI-TOF/TOF ... copies of H2A, H2B, H3 and H4 [4]. An additional histone, H1 links these nucleosomes together along the chromatin chain. In general, the N terminus of histone H3 and H4,...
Ngày tải lên: 12/08/2014, 03:21
báo cáo khoa học: " Global expression analysis of nucleotide binding site-leucine rich repeat-encoding and related genes in Arabidopsis" pps
... ligands, R proteins may also monitor ('guard') the status of the targets of pathogen virulence effectors, or the cellular consequences of the actions of these proteins [2,12-16]. The ... were sorted by their gene identifiers, which usually reflects their chromosomal locations, and then the expression pattern of NBS-LRR-encoding and related genes was vis...
Ngày tải lên: 12/08/2014, 05:20
Báo cáo khoa học: Structure–function analysis of the filamentous actin binding domain of the neuronal scaffolding protein spinophilin pot
... National Institute of Neurological Disorders and Stroke to WP. The content is solely the responsibility of the authors and does not necessarily represent the of cial views of the National Institute of Neurological ... description of the molecular components involved in the regulation and maintenance of dendritic spine morphology is funda- mental to our und...
Ngày tải lên: 16/03/2014, 06:20
Báo cáo khoa học: In silico analysis of the adenylation domains of the freestanding enzymes belonging to the eucaryotic nonribosomal peptide synthetase-like family pot
... manual and automated docking have been utilized to map the conserved residues onto a hypothetical active site structure, to under- stand the role of their conserved residues and predict their ... moiety tethered to the phosphopantetheinyl group and the free amino group of the downstream aminoacyl moiety, thus facilitating the translocation of the growing ch...
Ngày tải lên: 23/03/2014, 13:20
Báo cáo khoa học: TNFR1-induced activation of the classical NF-jB pathway Harald Wajant1 and Peter Scheurich2 pptx
... stimulation, TRAF2 and the associated cIAPs are recruited to TNFR1- bound TRADD with the help of the C-terminal half of the TRAF domain of TRAF2. Thus, the E3 ligases TRAF2, cIAP1 and cIAP2 enter the TNFR1 ... K31, together with analy- sis of PKCe knockout MEFs with knockdown of PKCd, revealed further evidence of a crucial role of K63-ubiquitination of the...
Ngày tải lên: 28/03/2014, 23:20
Báo cáo khoa học: "ACTH-producing carcinoma of the pituitary with refractory Cushing''''s Disease and hepatic metastases: a case report and review of the literature" pptx
... interests. Authors' contributions HC performed the bilateral adrenalectomy and together with SP and RS contributed to the conception and design of the manuscript, reanalyzed and interpreted the data and prepared ... prepared the manuscript. SP contributed to the con- ception and design of the manuscript, reanalyzed and interpreted the data and help...
Ngày tải lên: 09/08/2014, 04:21
Báo cáo khoa học: " Linkage disequilibrium pattern of the ATM gene in breast cancer patients and controls; association of SNPs and haplotypes to radio-sensitivity and post-lumpectomy local recurrence" doc
... illustration of the ATM gene. The distribution of the variations detected in the studied materials along the gene is shown in the upper panel with exonic variants indicated on top of the gene and intronic ... file 2 The estimated halotypes from the case-control analysis of the Norwegian individuals with the number of chromosomes predicted to represent...
Ngày tải lên: 09/08/2014, 10:21
Báo cáo khoa học: Comprehensive sequence analysis of horseshoe crab cuticular proteins and their involvement in transglutaminase-dependent cross-linking potx
... of the integrity of the exoskeleton. A cDNA of acidic DE25 encoded a 137-amino acid protein and a 22-amino acid signal peptide (AB201776). A partial cDNA of acidic DE29 lacked the 5¢-region and ... rage of isoelectric points from 3.5 to 10 [25]. Their isoelectric points range from 6.5 to 9.2, and the 2D gel shows no protein spots in the acidic range from 3....
Ngày tải lên: 07/03/2014, 21:20