Báo cáo y học: "CXCL10 blockade protects mice from cyclophosphamide-induced cystitis" ppsx

... by iliac lymph node lymphocytes compared to similar cells from unaffected mice. However, the expres- sion of IFN-γ, IL-12p40, and TNF-α mRNAs by urinary bladder lymphocytes from mice with cystitis ... administered beginning 2 days prior to CYP treatment and every 2 days thereafter. Five days after CYP administration, lymphocytes from the spleen, iliac lymph nodes, and urinary bladde...

Ngày tải lên: 11/08/2014, 10:23

... the series of Keystone Symposia focused on the intersection of microRNA (miRNA) and cancer biology. The meeting was characterized by the traditional hallmarks of Keystone Symposia: a defined ... history of nucleic acid drug development highlights many important challenges, including formulation and pharmacology. Josh Mendell (Johns Hopkins University, Baltimore, USA) and Frank Slack (Y...

Ngày tải lên: 14/08/2014, 21:20

... inflammatory bowel disease [4]. Analysis of synovial tissue, synovial fluid and peripheral blood from patients with rheumatoid arthritis (RA) revealed abundant expression of a variety of inflammatory ... usually bind multiple ligands and vice versa, one may anticipate that blockade of one ligand or receptor may be compensated for by other members of the superfamily. In addition, some liga...

Ngày tải lên: 09/08/2014, 01:23

... previously using C57BL/6J ENU-treated males, mated to the balancer, which was generated in 129S5SvEv embryonic stem cells. Embryos from the l11Jus74 linewereanalyzedfrom timed matings, as previously ... determined, polycystic kidneys have not been observed, making the most likely lesion to result in perinatal death Rundc3a, although the Nek8 mutation may cause a delayed onset phenotype. For...

Ngày tải lên: 09/08/2014, 23:20

... was created in Python programming language, using the NumPy and Scipy libraries. Results and Disc ussion The current study propo ses a systems biology approach to analyze the dynamic behavior ... virus. Keywords: Gene Regulatory Network, Time Varying Dynamic Bayesian Network, Immune System, Influenza A Background It is now well established that the study of biological com- plexity has shifted...

Ngày tải lên: 10/08/2014, 09:22

... TSP-1 is up-regulated by hypoxia in pulmonary arteries in piglets [33]. Likewise, TSP-1 has been found in intrapulmonary arteries in hypoxia-induced pulmonary hypertension in mice [14]. Nonetheless, ... pulmonary vascular smooth muscle cell hyperplasia reported in TSP-1 -/- mice previously by Crawford et al [15] (Figure 2). This suggests that the pulmonary smooth muscle cells hyperplasia...

Ngày tải lên: 10/08/2014, 09:22

... E: Quantification of peroxyni- trite, superoxide, and peroxyl radicals by a new spin trap hydroxylamine 1-hydroxy-2,2,6,6-tetramethyl-4-oxo-piperi- dine. Biochem Biophys Res Commun 1997, 230:54-57. 30. ... such studies. From our electrochemistry data we have esti- mated that the concentration of NO released from 10 μM DETA/NO is likely to be in the nM range and arguably a more realistical...

Ngày tải lên: 11/08/2014, 08:22

... indirect immunofluorescence analysis, as previously described [29], by using anti-mP GES-1 antibody (Cayman Chemi- cal Company, Ann Arbor, MI, USA) followed by an appropriate secondary antibody (Jackson ImmunoRe- search ... myofibroblast formation in vivo. (a) Hydroxyproline analysis showed reduced collagen content in mPGES-1 null mice compared with wild-type (WT) mice in response to bleo...

Ngày tải lên: 12/08/2014, 15:22

... three-layer sutures to elimi- nate the space remaining after lesion removal. A first deep layer with Vicryl 3-0, slightly affecting the mus- cle fascia. A second subcutaneous deep layer with ... informed consent was obtained from the patient for publication of this case report and accom - panying images. A copy of the written consent is available for review by the Editor-in-Chief of this...

Ngày tải lên: 25/10/2012, 11:35

... electron microscopy and serological as- say. Serum specimens from serologically negative healthy volunteers with no C. pneumoniae EB detecta- ble in serum sediments by electron microcopy were used ... viable elementary bodies of C.pneumoniae in serum samples of patients with acute coronary syndrome and healthy volunteers. MATERIAL AND METHODS: Serum specimens from 26 healthy voluntee...

Ngày tải lên: 26/10/2012, 08:57