Báo cáo y học: "IMP321 (sLAG-3), an immunopotentiator for T cell responses against a HBsAg antigen in healthy adults: a single blind randomised controlled phase I study" ppt

... immunoassays, data acquisi-tion and analysis. MM carried out blood cells isolationand stimulation. GP was involved in the coordination ofthe study and in the drafting of the manuscript. FT ... that are potent inducers ofinflammation ("danger signals"). In addition to the TLR agonists that are innate immunityligands, the immune response involves two adaptiveimmunity ligands ... responses against a HBsAg antigen in healthy adults: a single blind randomised controlled phase I studyChrystelle Brignone, Caroline Grygar, Manon Marcu, Gaëlle Perrin and Frédéric Triebel*Address:...

... CCAGATGAAAACTCGCTGGATTTTTCCTCCTGTATGTTACGGCCGCCTCACAGCCAGATGAAAACTCGCTGGATTTTTCCTCCTGTATGTTACGGCCCAGATGAAAACTCGCTGGATTTTTCCTCCTGTATGTTACGGCCTGGGAATGAAAACTCGCTGGATTTTTCCTCCTGTATGTTACGGCCTGGGATTAAAAAAACTCGCTGGATTTTTCCTCCTGTATGTTACGGCCTGGGATTAAAAATACTCGCTGGATTTTTCCTCCTGTATGTTACGGCCTGGGATTAAAAATGCTCGCTGGATTTTTCCTCCCGTATGTTACGGCCTGGGATTAAAAATGCTCAGTGGATTTTTCCTCCTGTATGTTACGGCCTGGGATTAAAAATGCTCAGGAGATTTTTCCTCCTGTATGTTACGGCCTGGGATTAAAAATGCTCAGGAGCTTTCCTCCTGTATGTTACGGCCTGGGATTAAAAATGCTCAGGAGCTTGCCTGTCCTGTATGTTACGGCCTGGGATTAAAAATGCTCAGGAGCTTGCCTGTGGTGTATGTTACGGCCTGGGATTAAAAATGCTCAGGAGCTTGCCTGTGGAGCTGTTACGGCCTGGGATTAAAAATGCTCAGGAGCTTGCCTGTGGAGTGTGCTACGGCCTGGGATTAAAAATGCTCAGGAGCTTGCCTGTGGAGTGTGCCTCGGCCTGGGATTAAAAATGCTCAGGAGCTTGCCTGTGGAGTGTGCCTCTTGCTGGGATTAAAAATGCTCAGGAGCTTGCCTGTGGAGTGTGCCTCTTGAATGGATTAAAAATGCTCAGGAGCTTGCCTGTGGAGTGTGCCTCTTGAATGTGTTAAAAATGCTCAGGAGCTTGCCTGTGGAGTGTGCCTCTTGAATGTGGACAAAATGCTCAGGAGCTTGCCTGTGGAGTGTGCCTCTTGAATGTGGACTCGATGCTCAGGAGCTTGCCTGTGGAGTGTGCCTCTTGAATGTGGACTCGAGGCTCAGGAGCTTGCCTGTGGAGTGTGCCTCTTGAATGTGGACTCGAGGAGCAGGAGCTTGCCTGTGGAGTGTGCCTCTTGAATGTGGACTCGAGGAGCCGGAGCTTGCCTGTGGAGTGTGCCTCTTGAATGTGGACTCGAGGAGCCGGGCATTGCCTGTGGAGTGTGCCTCTTGAATGTGGACTCGAGGAGCCGGCCTGTGGAGTGTGCCTCTTGAATGTGGACTCGATGAGCCGGGTGGAGTGTGCCTCTTGAATGTGGACTCGAGGAGCCGGGAGTGTGCCTCTTGAATGTGGACTCGAGGAGCCGGTGTGCCTCTTGAATGTGGACTCGAGGAGCCGGGCCTCTTGAATGTGGACTCGAGGAGCCGGTCTTGAATGTGGACTCGAGGAGCCGGchr17 ... (25bp)TTAACACTATCTAAAATCAATTTTC AATGATAGCGACGACTGCGTCATAGchr i GAATTTCCTG TTAACACTATCTAAAATCAATTTTC TTTTACAGGTACATTGTAGTTTTAT GAATATGGCTCCGGTCAACAGTAAC AATGATAGCGACGACTGCGTCATAG TCAGTGAATCchr j135223330 ... CCAGATGAAAACTCGCTGGATTTTTCCTCCTGTATGTTACGGCCGCCTCACAGCCAGATGAAAACTCGCTGGATTTTTCCTCCTGTATGTTACGGCCCAGATGAAAACTCGCTGGATTTTTCCTCCTGTATGTTACGGCCTGGGAATGAAAACTCGCTGGATTTTTCCTCCTGTATGTTACGGCCTGGGATTAAAAAAACTCGCTGGATTTTTCCTCCTGTATGTTACGGCCTGGGATTAAAAATACTCGCTGGATTTTTCCTCCTGTATGTTACGGCCTGGGATTAAAAATGCTCGCTGGATTTTTCCTCCCGTATGTTACGGCCTGGGATTAAAAATGCTCAGTGGATTTTTCCTCCTGTATGTTACGGCCTGGGATTAAAAATGCTCAGGAGATTTTTCCTCCTGTATGTTACGGCCTGGGATTAAAAATGCTCAGGAGCTTTCCTCCTGTATGTTACGGCCTGGGATTAAAAATGCTCAGGAGCTTGCCTGTCCTGTATGTTACGGCCTGGGATTAAAAATGCTCAGGAGCTTGCCTGTGGTGTATGTTACGGCCTGGGATTAAAAATGCTCAGGAGCTTGCCTGTGGAGCTGTTACGGCCTGGGATTAAAAATGCTCAGGAGCTTGCCTGTGGAGTGTGCTACGGCCTGGGATTAAAAATGCTCAGGAGCTTGCCTGTGGAGTGTGCCTCGGCCTGGGATTAAAAATGCTCAGGAGCTTGCCTGTGGAGTGTGCCTCTTGCTGGGATTAAAAATGCTCAGGAGCTTGCCTGTGGAGTGTGCCTCTTGAATGGATTAAAAATGCTCAGGAGCTTGCCTGTGGAGTGTGCCTCTTGAATGTGTTAAAAATGCTCAGGAGCTTGCCTGTGGAGTGTGCCTCTTGAATGTGGACAAAATGCTCAGGAGCTTGCCTGTGGAGTGTGCCTCTTGAATGTGGACTCGATGCTCAGGAGCTTGCCTGTGGAGTGTGCCTCTTGAATGTGGACTCGAGGCTCAGGAGCTTGCCTGTGGAGTGTGCCTCTTGAATGTGGACTCGAGGAGCAGGAGCTTGCCTGTGGAGTGTGCCTCTTGAATGTGGACTCGAGGAGCCGGAGCTTGCCTGTGGAGTGTGCCTCTTGAATGTGGACTCGAGGAGCCGGGCATTGCCTGTGGAGTGTGCCTCTTGAATGTGGACTCGAGGAGCCGGCCTGTGGAGTGTGCCTCTTGAATGTGGACTCGATGAGCCGGGTGGAGTGTGCCTCTTGAATGTGGACTCGAGGAGCCGGGAGTGTGCCTCTTGAATGTGGACTCGAGGAGCCGGTGTGCCTCTTGAATGTGGACTCGAGGAGCCGGGCCTCTTGAATGTGGACTCGAGGAGCCGGTCTTGAATGTGGACTCGAGGAGCCGGchr17...

... [12].Liver transplantation and acetaminophenpoisoningThere are no standard selection criteria for transplantationthat are in use worldwide, but the King’s College Hospitalcriteria (Table 2) are the ... than vomiting.Gyamlani and Parikh [7] recommended that patients withdeliberate acetaminophen poisoning be managed on medicalfloors, but that patients with accidental ingestion and chronicalcoholic ... criteria representthe best tool for identifying patients who requiretransplantation.Table 1When to contact a specialist liver centre in patients withacetaminophen-induced hepatotoxicityProgressive...

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... Hamad M, Muta’eb E, Abu Shaqra Q, et al. Utility of the estrogen- dependent vaginal candidiasis murine model in evaluating the e-cacy of various therapies against vaginal C. albicans infection. ... and from estrogen- treated Candida albicans–infected experimental mice at day  postinfection were sepa-rately pooled from ve to six mice and stained with anti- CD and anti- CD for two- ... matched mice that received either a single intravaginal injection of . mL autoclaved phosphate- buered saline (PBS) or a single  L intravaginal inoculum of  ×  viable stationary-...

... Nozaki S, Inagaki A, Furukawa TA: Efficacy of diazepam as an anti-anxiety agent: meta-analysis of double -blind, randomized controlled trials carried out in Japan. Human Psychopharmac Clin Exp ... ANOVA indicatedsignificant practice effects of repeated testing, but noteffects of drug group, on test scoring without a signifi-cant interaction, in some tests including trail makingtest A ... word. Three sets of immediatememory testing and one set of delayed recall testingwere administered.Statistical analysisTwo-way repeated measures analysis of variance(ANOVA) was performed to assess...

... participated in patientrecruitment, statistical analysis, and manuscript preparation.HH participated in the coordination of the study and helpedwith patient recruitment and manuscript preparation. ... factor for inflammation.IntroductionRheumatoid arthritis (RA) is a chronic inflammatory diseasecharacterised by intense immune activation within the synovialcompartment of joints and a variety ... summarised in Table 1. Tests for antibodies to cyclic citrullinated peptides (anti-CCP anti-bodies) of nine patients with RA were available. Sevenpatients with RA were positive for anti-CCP antibodies,whereas...

... development of OA, thisstudy suggests that dietary modification of fatty acid intake maybe one strategy in the prevention of knee OA which warrantsfurther investigation.IntroductionNutritional factors ... no significant association between fattyacid consumption and the incidence of BMLs over 2 years in univariate analysis, higher consumption of saturated fatty acidswas significantly associated ... Com-mittee and the Standing Committee on Ethics in ResearchInvolving Humans of Monash University. All participants gavewritten informed consent.Anthropometric and dietary dataHeight was measured...

... prior torethoracotomy, because of hemodynamical instabilityand high clinical suspicion of tamponade these patientswent straight to the operating room. In the remaining19 patients echocardiography ... evenechocardiographic variables obtained in the ICU. Ourdata suggest that in patients with severe haemodynamiccompromise in the ICU after primary cardio-thoracicsurgery, without heparin but having ... -9,11,13]. The latter may facilitate detection of haemo-dynamic compromise, but data may be confounded bycardiac function , concomitant mechanical ventilationand vasopressor/inotrop ic therapy. Many...

... Epstein-Barr-virus-positive T cell lymphoproliferative childhood disease in a 22-year-old Caucasian man: A case report andreview of the literatureValentina Tabanelli1, Claudio Agostinelli1, Elena Sabattini1, Anna ... research, analyzed data and wrote the manuscript; CAperformed research and analyzed data; ES and FB analyzed data; SC and GMwere responsible for patient care and provided clinical information; ... children andyoung adults, appears to be more common in Asians andNative Americans, and is associated with r apid progression,high morbidity and mortality. It can develop after primaryEBV infection...