Báo cáo y học: "soriatic arthritis: Pathogenesis and novel immunomodulatory approaches to treatment" doc

... These cytokines can induce prolif- eration and activation of synovial and epidermal fibroblasts, leading to fibrosis in patients with longstand- ing PsA. TNF-α, a key proinflammatory cytokine, ... synovium [29]. The cytokine network in the psoriatic skin and synovium is dominated by monocyte and T-cell derived cytokines: IL-1β, IL-2, IL-10, IFN-γ and TNF-α [30]. In PsA synovium, h...

Ngày tải lên: 11/08/2014, 10:23

... adher- ence to therapy. On the other hand, the 1-year level of adher- ence to therapy found in our study closely resembles values found in randomised controlled clinical trials. We found 1-year level ... patients who tolerate MTX well also are likely to tol- erate TNF-blocking agents. Thus, tolerance to MTX therapy may be used as a surrogate measure for potential high tolera- bility o...

Ngày tải lên: 09/08/2014, 08:23

... to synovial hypertrophy and siderosis, due to phagocytosis of erythrocytes and hemoglobin by synovial cells. Synovitis develops only at later stages and may be triggered by mediators that result ... cartilage and other joint structures slowly progress through a long clinically asymptomatic latency period to a symptomatic phase with joint pain and dysfunction. In the majo...

Ngày tải lên: 12/08/2014, 14:22

... associated with extrapyramidal symptoms, and this may have an aggravating affect on clinical depression progress and the emergence of suicidal ideation. Background Extrapyramidal symptoms (EPSs) are ... obviously very depressed and anxious with no psychotic symptoms and she reported suicidal ideation for the last 10 days. Her neurological examin ation revealed severe rigidity and br...

Ngày tải lên: 08/08/2014, 23:21

... prominent immunoregulatory effects and might act as key cytokines, not only in the innate immune system but also in adaptive immune responses. Immunomodulatory effects by type I IFNs Type I IFNs have ... switching and plasmacytoid differentiation. Autoantibody production is facilitated by the ability of DNA/RNA-containing autoantigens to activate B cells directly by simultaneous bindi...

Ngày tải lên: 09/08/2014, 01:21

... immunostaining Cryosections were fixed in acetone for procollagen type I, and collagen types I and III staining. For collagen type II staining paraffin sections were deparaffinized using xylene and rehydrated ... or cryomicrotome and mounted on Starfrost ® slides (Knittel, Braunschweig, Germany). Paraffin sections were haematoxylin and eosin stained as well as immunostained for col...

Ngày tải lên: 09/08/2014, 01:24

... Tokgoz-Yilmaz S, Cengiz FB, Aslan I, Yildirim M, Hasanefendioglu-Bayrak A, Aycicek A, Yilmaz I, Fitoz S, Altin F, Ozdag H, Tekin M: Mutations in TMC1 contribute significantly to nonsyndromic autosomal ... (Fig- ure 2). The proband is homozygous for MYO15A c.4240G > A (p.E1414K), a novel mutation predicted to be damaging by Polyphen2 and SIFT (Tables 2 and 3). WFS1 Family K13576 i...

Ngày tải lên: 09/08/2014, 23:20

... All authors read and approved the final manuscript. Acknowledgements This study was sponsored by grants from the Muscular Dystrophy Society and by Geisinger Health System to Yiumo Chan References 1. ... Neurophysiologic Monitoring. Humana Press (Totowa NJ); 2005. 2. Happel L, Kline D: Intra-Operative neurophysiology of the peripheral nervous system in Neurophysiology in Neurosur- gery:...

Ngày tải lên: 10/08/2014, 10:20

... commonly followed by other psychiatric symptoms, such as anxiety and depression [27,28]. Occurrence of inappropriate eating behaviors and eating disorders may Nunes et al. BMC Psychiatry 2010, ... this study are: to identify food intake and eating behaviors patterns; to estimate the prevalence of common mental disorders and the experience of violence during and after pregnancy;...

Ngày tải lên: 11/08/2014, 16:22

... aponeuroses. Glandular ducts were not dilated and no calculus was observed. Both larynx and pharynx were markedly edematous and the airway lumen was totally obliterated so that no empty space was observed ... submandibular glands can appear during surgery or in the early postope rative period, but does not usually involve the airways, and resolves spontaneously within 5 to 7 days [6...

Ngày tải lên: 11/08/2014, 17:21