Báo cáo y học: "Identification of proteases employed by dendritic cells in the processing of protein purified derivative (PPD)" pdf

... pepstatin A had primarily inhibited the processing events. Functional role of cathepsin D/E in the processing of PPD by XS52 DC To identify the protease(s) inhibited by pepstatin A, XS52 DC were ... and Vaccines Open Access Original research Identification of proteases employed by dendritic cells in the processing of protein purified derivative (...

Ngày tải lên: 11/08/2014, 10:23

... equally during the field work, data analysis and preparation of the manuscript, and read and approved the final manuscript. Competing interests The authors declare that they have no competing interests. Figure ... [39]. The cost and availa bility of medicines and providers is a factor driving the use of alternative providers, including self-treatment using eth- noveterinary...

Ngày tải lên: 10/08/2014, 09:21

... useful in the management of septic shock Katherine G Craig and Keith R Walley The debate surrounding the use of corticosteroids in septic patients has continued for over 30 years. Two meta- analyses ... has conflicting support in the literature. In this issue of Critical Care Forum, the two sides of this often heated debate are brought to the forefront in an inte...

Ngày tải lên: 12/08/2014, 18:21

... mortality. They included a study by Luiten and colleagues [8], which used selective decontamination of the digestive tract. Selective decontamination is attractive as it may allow the use of prophylaxis ... mortality rate, 0% versus 15%), but no difference in the rate of infection of pancreatic necrosis [4]. Pooling of the data from these 183 patients by Bosscha and co...

Ngày tải lên: 12/08/2014, 19:22

... and increasing the inotropic effect of insulin [21,24]. Recommendations for the use of HIET in CCB poisoning Although there is wide variation in insulin dosing in the cases reporting the use of HIET in ... Improvement of heart performance induced by low-dose insulin was not accompanied by an increase in myocardial oxygen consumption. Myocardial uptake of glucos...

Ngày tải lên: 12/08/2014, 23:23

... [30]. In the current study, the M4 mutant was studied to clarifying why oligomer formation is essential for Rev activity by assessing the requirements for restora- tion of the activity of the mutant. Results The ... Rex. The function of the HTLV-I Rex protein is similar to that of Rev and the basic domains from the two viral proteins bind to Importin β during...

Ngày tải lên: 13/08/2014, 09:21

... presented by coefficient of variance (CV). CVs are calculated by dividing the standard deviation (SD) by the mean ratio of a gene and multiplying by 100%. The minimum and maximum numbers of measurements ... the Cyber-T implementation of a variant of the t-test [31]. False discovery rates (FDRs) were calculated by (i) ranking the genes by p-value, (ii) mult...

Ngày tải lên: 14/08/2014, 14:21

... that bind to the SH2 domains. The tandem SH2 domains bind to Tyr-627 and Tyr-659 simultaneously in a specific orientation, in which Tyr-627 binds to the N-SH2 domain and Tyr-659 binds to the ... previously that G/G of the PTPN11 gene encoding SHP-2 increased the risk of gastric atrophy among the seropositive subjects [18]. The present study examined the associat...

Ngày tải lên: 31/10/2012, 15:37

... amino-acid composition of hyperthermophilic proteins is the bias against thermally labile amino-acid residues. This pattern is obvious on examination of the amino-acid compositions of the total protein content of ... increase from the apoenzyme to the Mn 2þ -containing enzyme, loss of the metal cofactor could be the limiting step in BLXI inactivation. Higher E a va...

Ngày tải lên: 22/02/2014, 07:20

... as outcomes of such calculations may be spoiled by inaccurate positioning of the interacting groups. The contact area of the distamycin amidinium end was investigated by evaluating the hydrogen positions ... between the pyrrole rings form bifurcated hydrogen bonds with the thymine or adenine bases. The central N5(D) atom of the drug is hydrogen-bonded to the two...

Ngày tải lên: 24/03/2014, 04:21