Báo cáo khoa hoc:" Topical latanoprost causes posterior movement of lens in a patient with exfoliation syndrome and subluxated lens: a case report" ppt

... cor-nea and lens will reduce the overall refractive power of theChange in lens position after topical latanoprostFigure 2Change in lens position after topical latanoprost. Photographs before latanoprost ... ciliary body thickness after topical application of pharmacogic agents. Am J Ophthalmol 1996,121:319-321.2. Mishima HK, Masuda K, Kitazawa Y, Azuma I: A comparison of latanoprost and timolol in ... pseu-doexfoliation glaucoma [7,8]. Our patient with the pseu-doexfoliation syndrome and subluxated lens offered us anopportunity to examine the effect of topical latanoprost on the position of...

Tài liệu Báo cáo khoa học: nsights into the reaction mechanism of glycosyl hydrolase family 49 Site-directed mutagenesis and substrate preference of isopullulanase doc

... CTGACCTtcTGGCATAACACCGGtGAAATCAgeIW32F CCTGGTtcCATAACACCGGtGAAATCAgeIW240F GGTGCTgAGCTCAAGTGTGACTTtcGTCTACSacIW402F CCGGTGGTcGAcTTTGGTTtcACGCCCSalIE273Q ACGTACTGCTgTCCGGAAAGtACtCCATGGCCGCScaID353N ... ACGTACTGCTgTCCGGAAAGtACtCCATGGCCGCScaID353N TCCAATCCGTtAGTCTGgCCaTAGAACGCGCMscIE356Q GGAGAATGGTgCCAGGGTACATTTcCAATCCGTCAKpnID372N AATACATCTTaAGGCCGTCGTtGTCGGTGTGG A IID373N AATACATCTTaAGGCCGTtGCGTCGGTG A IIÓ FEBS ... catalyst of pK a 5.9, and that the adjacent Glu180 is negatively charged, raisingthe p K a of the general acid catalyst [23]. I t is likely t hatcatalytic residues of IPU adopt a similar catalytic...

Báo cáo khoa học: The natural mutation by deletion of Lys9 in the thrombin A-chain affects the pKa value of catalytic residues, the overall enzyme’s stability and conformational transitions linked to Na+ binding pdf

... than in the WT form(33 min).Characterization of stabilizing interactionsbetween A- and B-chains In WT thrombin, the A- chain assumes an overallboomerang-like shape interacting with the B-chain ... experimentally. In analogy with the values calculated in enzymaticexperiments, an increase of % 0.5 pK units of theHis57 in DK9 mutant was also calculated analyzing theNAPAP data set (Table 1C). In ... ⁄rearrangement of the W60d side chain (S2 site) and shifting of W215 (S3). Functional and computationaldata show that the catalytic cycle and efﬁcient interac-tion with substrates and natural inhibitors...

Báo cáo khoa học: New evidence for the role of calcium in the glycosidase reaction of GH43 arabinanases pot

... a- l-1,2-, a- l-1,3- and a- l-1,5-arabinosyl residues from various oligosac-charides and polysaccharides, including arabinan, ara-binoxylan and arabinogalactan [6,7]. ABNs attack theglycosidic bonds of ... comprisesall 443 amino acids of the mature protein. BsArb43Bconsists of two domains, an N-terminal catalyticdomain (Ala28–Tyr367) and a C-terminal domain(Ala368–Ala470). The catalytic domain displays ... a- 1,5-l-arabinan, releasing arabino-oligosaccharides and l-arabinose. Two extracellular endo-1,5 -a- l-arabinanases have beenisolated from Bacillus subtilis, BsArb4 3A and BsArb43B (formally namedAbnA...

Báo cáo khoa học: Multidrug efflux pumps: The structures of prokaryotic ATP-binding cassette transporter efflux pumps and implications for our understanding of eukaryotic P-glycoproteins and homologues ppt

... this cation, as well asanother DNA-intercalating agent Hoescht 33342.Furthermore, membranes containing MsbA have anATPase activity that is stimulated by daunomycin, and can interact with a further ... struc-ture of MsbA in liposomes and mapped conformationalchanges during the ATPase cycle by EPR analysis of 112 spin-labelled mutants trapped in four intermediatestates, including apo and AMP–PNP ... across the ABC transporterfamily [17], and two transmembrane domains (TMDs) with six membrane-spanning a helices (although as dis-cussed later, ABCC1 contains an additional N-terminaldomain).This...

Báo cáo khoa học: B1–Proteases as Molecular Targets of Drug Development B1-001 DPP-IV structure and inhibitor design ppt

... of synthesized and natural substrates, azocasein, azoalbu-min, hemoglobin, casein, gelatin and egg albumin. The enzymeappears to prefer azocasein with Km 2 mg azocasein/ml. Theenzyme had a ... to leak into the medium from RPEcells, and calpain inhibitor SJA6017 inhibited the leakage. Caseinzymography and immunoblotting for calpain and a- spectrinshowed activation of calpain in RPE ... and extracellular matrix proteins, important compounds in inﬂamma-tory intestinal disease and in cancer metastases. To investigate therole of meprins in intestinal immune responses, in ammation...

Báo cáo khoa học: " Host Immune Responses Against Hog Cholera Virus in Pigs Treated with an Ionized Alkali Mineral Complex" pot

... vaccination pigs were variable in the level of maternal antibody titers (<1:4~1:256). Mean antibodytiters of each group against HCV increased gradually afterthe vaccination of the attenuated ... one of the major diseases that are threatening the expandingKorean swine industry since 1947 [7]. Thus, the nationaleradication program of a virulent hog cholera virus infection in the industry ... daysold and the second vaccination at 60 days old, with annuallybooster injection for adults. Since December, 2001 theKorean government has ceased vaccination policy againsthog cholera.As a nonspecific...

Báo cáo khoa học: "Surgical treatment for different forms of hernias in sheep and goats" ppt

... ...

Báo cáo khoa học: "Soft tissue non-Hodgkin lymphoma of shoulder in a HIV patient: a report of a case and review of the literature" pps

... showed a monoclonal rearrange-ment of IgH chain (Figure 3) and a polyclonal pattern forTCR gamma and beta (data not shown). A final diagnosis of diffuse large cells B-lymphoma was made.The patient ... of case report. All authors read and approved the final manu-script.References1. Larocca LM, Capello D, Rinelli A, Nori S, Antinori A, Gloghini A, Cin-golani A, Migliazza A, Saglio G, Cammilleri-Broet ... immunostaining images (C-F)Figure 2Hematoxylin and eosin (A, B) staining of the lesion and representative immunostaining images (C-F). Shown are immunostatining examples of CD20 (C), Bcl-6 (D), PAX-5...

Báo cáo khoa học: " Ramipril mitigates radiation-induced impairment of neurogenesis in the rat dentate gyrus" potx

... signalingwithin the SGZ. Ang II, acting primarily via AT2R, is a well established promoter of trauma-induced apoptosis in a variety of tissues, including brain, and administeringAT2R antagonists has been ... the magnitude of long-term potentiation in the dentate gyrus and associative learning in the rat. A demonstration using commissural inhibition and local infusion of an N-methyl, D. aspartate receptor ... receptors,AT1R and AT2R, which are broadly distributed in thebrain and particularly dense in the hippocampus [23].After tissue injury, AT2Rs are upregulated and Ang II, in combination with other...

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