Báo cáo y học: "Cigarette smoke regulates VEGFR2-mediated survival signaling in rat lungs" pot
Báo cáo y học: "Cigarette smoke regulates the expression of TLR4 and IL-8 production by human macrophages" pdf
... and therefore protecting the cells against oxidants (indirect effect) by modulating the redox signaling pathways [22,23]. Thus these results indicate that CSM by inducing ROS generation, may modulates ... demonstrated that ROS play an important role in CSM-induced TLR4 associated intracel- lular signaling. Interestingly, we have found that CSM spe- cifically induced phosphorylation of IR...
Ngày tải lên: 11/08/2014, 08:22
Báo cáo y học: "Cigarette smoke regulates VEGFR2-mediated survival signaling in rat lungs" pot
... Sprague-Dawley rats were exposed CS for 3 days, 8 weeks and 6 months to investigate the effect of CS on VEGFR2-mediated survival signaling by measuring the Akt/PI3-kinase/eNOS downstream signaling in rat ... receptor 2 or kinase insert domain receptor (a type III receptor tyrosine kinase) or protein-tyrosine kinase receptor FLk-1 (VEGFR2) is key in endothelial survival and th...
Ngày tải lên: 11/08/2014, 08:22
Báo cáo y học: "Cigarette smoke promotes dendritic cell accumulation in COPD; a Lung Tissue Research Consortium study" pdf
... 107(4):604-611. 40. Mamata Y, Hakki A, Yamamoto Y, Newton C, Klein TW, Pross S, Friedman H: Nicotine modulates cytokine production by Chlamydia pneumoniae infected human peripheral blood cells. Int Immunopharmacol ... 5(4):749-756. 41. Matsunaga K, Klein TW, Friedman H, Yamamoto Y: Involvement of nicotinic acetylcholine receptors in suppression of antimicrobial activity and cytokine...
Ngày tải lên: 12/08/2014, 11:21
Báo cáo y học: "Cigarette smoke exposure facilitates allergic sensitization in mice" pps
... filter)(Uni- versity of Kentucky, Lexington, KY, USA) for 7 min, 4 times a day. Carboxyhemoglobin-levels in blood were 8.29 ± 1.4% in smoke- exposed vs. 1.02 ± 0.22% in air- exposed mice (n = 7). During air or smoke ... ovalbumin (OVA) combined with air or tobacco smoke (4 exposures/day) daily for three weeks. Serology, lung cytopathology, cytokine profiles in bronchoalveolar lav...
Ngày tải lên: 12/08/2014, 16:20
Báo cáo y học: "Cigarette Smoke Exposure Alters mSin3a and Mi-2α/β Expression; implications in the control of pro-inflammatory gene transcription and glucocorticoid function" ppt
... inflammatory response in the lungs of mice which is linked to a reduction in HDAC activity and may be a key mechanism of glucocorticoid insensitivity in COPD [11,17,21]. Both this reduction in HDAC ... plethora of pathways both directly and in directly. Therefore it is unlikely that a change in a single proteins activity, expression or function would be solely responsi- ble for el...
Ngày tải lên: 11/08/2014, 03:20
Báo cáo y học: "Cigarette Smoke Exposure Alters mSin3a and Mi-2α/β Expression; implications in the control of pro-inflammatory gene transcription and glucocorticoid function" pdf
... PI3K signaling with glucocorticoid treatment. Inhibition of PI3Kδ signalling in combination with glucocorticoid treatment may therefore provide a therapeutic strategy for restoring oxidant-induced ... Protein kinase CK2-mediated phosphorylation of HDAC2 regulates co-repressor formation, deacetylase activity and acetylation of HDAC2 by cigarette smoke and aldehydes. Arch Biochem B...
Ngày tải lên: 11/08/2014, 06:22
Báo cáo y học: " Cigarette smoke exacerbates mouse allergic asthma through Smad proteins expressed in mast cells" pps
... (Figure 8). This inference was confirmed by inhibitors of Lyn an d Syk kinases, which are down- stream kinases in FcεRI signaling pathways, and by TGF-b receptor kinase inhibitor. This inference was ... Funada Y, Kotani Y, Sisson TH, Simon RH, Nishimura Y: Inhalation of urokinase-type plasminogen activator reduces airway remodeling in a murine asthma model. Am J Physiol Lung Cell Mo...
Ngày tải lên: 12/08/2014, 13:22
Báo cáo y học: " Cigarette smoke worsens lung inflammation and impairs resolution of influenza infection in mice" ppt
... assayed by zymography, and net gelatinase activity in BALF assayed by digestion of fluorescein cou- pled gelatin, as previously described [12]. Densitometry of zymography gels was done using ... purposes) Flow cytometry quantitation of T lymphocytesFigure 6 Flow cytometry quantitation of T lymphocytes. CD3+ CD4+ lymphocytes in (a) BALF & (b) LNs, and CD3+ CD8+ lym- phocytes in (c) B...
Ngày tải lên: 12/08/2014, 15:21
Báo cáo y học: " Cigarette smoke induces IL-8, but inhibits eotaxin and RANTES release from airway smooth muscle" pot
... inflammation in cigarette smokers, where inflammatory cytokines, including TNFα, are usually present in the lung [28]. In mice, TNFα appears to be a central mediator for smoke- induced inflammation ... neutrophilic inflammation and release of proinflammatory mediators such as interleukin-8 (IL-8). Human airway smooth muscle cells (HASMC) are a source of proinflammatory cytokines and c...
Ngày tải lên: 12/08/2014, 18:21
Tài liệu Báo cáo Y học: Systematic search for zinc-binding proteins in Escherichia coli potx
... N-terminal sequencing. In addition to five known zinc-binding proteins, nine zinc- binding proteins were newly identified including: acetate kinase (AckA), DnaK, serine hydroxymethyltransferase (GlyA), ... zinc-containing protein with the zinc finger or zinc cluster exist in yeast, which, however, lacks proteins with the hormone receptor-type zinc-binding motif. This type of zinc-binding pro...
Ngày tải lên: 22/02/2014, 04:20