Báo cáo y học: "Cigarette smoke regulates VEGFR2-mediated survival signaling in rat lungs" pot
Báo cáo y học: "Cigarette smoke regulates the expression of TLR4 and IL-8 production by human macrophages" pdf
... andtherefore protecting the cells against oxidants (indirecteffect) by modulating the redox signaling pathways[22,23]. Thus these results indicate that CSM by inducingROS generation, may modulates ... demonstrated that ROS play animportant role in CSM-induced TLR4 associated intracel-lular signaling. Interestingly, we have found that CSM spe-cifically induced phosphorylation of IRAK-1 in stablytransfected ... thehydroxyl radical [22]. By using a direct approach to meas-ure ROS production, CSM dose dependently increasesintracellular ROS generation by MDMs. These findingsmay suggest that CSM induces...
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Báo cáo y học: "Cigarette smoke regulates VEGFR2-mediated survival signaling in rat lungs" pot
... Sprague-Dawley rats were exposed CS for 3 days, 8 weeks and 6 months to investigate theeffect of CS on VEGFR2-mediated survival signaling by measuring the Akt/PI3-kinase/eNOS downstream signaling in rat ... receptor 2 or kinaseinsert domain receptor (a type III receptor tyrosinekinase) or protein-tyrosine kinase receptor FLk-1(VEGFR2) is key in endothelial survival and th e mainte-nance of the ... cell death in lung has not been studied. Therefore, we hypothesizedthat CS regulates VEGFR2-mediated survival signaling via Akt-dependent pa thways in rat lung. To test thishypothesis, rats were...
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Báo cáo y học: "Cigarette smoke promotes dendritic cell accumulation in COPD; a Lung Tissue Research Consortium study" pdf
... 107(4):604-611.40. Mamata Y, Hakki A, Yamamoto Y, Newton C, Klein TW, Pross S, Friedman H: Nicotine modulates cytokine production by Chlamydia pneumoniae infected human peripheral blood cells. Int Immunopharmacol ... 5(4):749-756.41. Matsunaga K, Klein TW, Friedman H, Yamamoto Y: Involvement of nicotinic acetylcholine receptors in suppression of antimicrobial activity and cytokine responses of alveolar macrophages ... determined whether induction of Bcl-xLprotein by CSE was primarily induced by oxidative con-stituents. To determine this, whole cell protein lysateswere prepared from human dendritic cells incubated...
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Báo cáo y học: "Cigarette smoke exposure facilitates allergic sensitization in mice" pps
... filter)(Uni-versity of Kentucky, Lexington, KY, USA) for 7 min, 4times a day. Carboxyhemoglobin-levels in blood were8.29 ± 1.4% in smoke- exposed vs. 1.02 ± 0.22% in air-exposed mice (n = 7). During air or smoke ... ovalbumin (OVA) combined with air ortobacco smoke (4 exposures/day) daily for three weeks. Serology, lung cytopathology, cytokineprofiles in bronchoalveolar lavage fluid (BALF) and on mediastinal ... detec-tion limit in all groups.Cytokine levels in supernatants of lymph node cell culturesSince a distinct allergic inflammation was observed in mice concurrently exposed to OVA and smoke, we inves-tigated...
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Báo cáo y học: "Cigarette Smoke Exposure Alters mSin3a and Mi-2α/β Expression; implications in the control of pro-inflammatory gene transcription and glucocorticoid function" ppt
... inflammatory response in thelungs of mice which is linked to a reduction in HDACactivity and may be a key mechanism of glucocorticoidinsensitivity in COPD [11,17,21]. Both this reduction in HDAC ... plethora of pathways both directly and in directly.Therefore it is unlikely that a change in a single proteinsactivity, expression or function would be solely responsi-ble for eliciting both a chronic ... machinery including the corehistone proteins resulting in their in re-association withthe DNA, thus presenting a transcriptionally closed con-formation [1,16].HDAC-2 function is impaired by...
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Báo cáo y học: "Cigarette Smoke Exposure Alters mSin3a and Mi-2α/β Expression; implications in the control of pro-inflammatory gene transcription and glucocorticoid function" pdf
... PI3K signaling with glucocorticoid treatment. Inhibition of PI3Kδ signalling in combination with glucocorticoid treatment may therefore provide a therapeutic strategy for restoring oxidant-induced ... Protein kinase CK2-mediated phosphorylation of HDAC2 regulates co-repressor formation, deacetylase activity and acetylation of HDAC2 by cigarette smoke and aldehydes. Arch Biochem Biophys 2010, ... machinery including the corehistone proteins resulting in their in re-association withthe DNA, thus presenting a transcriptionally closed con-formation [1,16].HDAC-2 function is impaired by...
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Báo cáo y học: " Cigarette smoke exacerbates mouse allergic asthma through Smad proteins expressed in mast cells" pps
... (Figure 8). This inference was confirmed byinhibitors of Lyn an d Syk kinases, which are down-stream kinases in FcεRI signaling pathways, and byTGF-b receptor kinase inhibitor. This inference was ... Funada Y, Kotani Y, Sisson TH, Simon RH, Nishimura Y: Inhalation of urokinase-typeplasminogen activator reduces airway remodeling in a murine asthmamodel. Am J Physiol Lung Cell Mol Physiol ... Kim DY, Ryu SY, Lim KE, Lee YS, Ro JY: Anti-inflammatory mechanism ofsimvastatin in mouse allergic asthma model. Eur J Pharmacol 2007,557:76-86.32. Kim JY, Kim DY, Ro JY: Granule formation in...
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Báo cáo y học: " Cigarette smoke worsens lung inflammation and impairs resolution of influenza infection in mice" ppt
... assayed by zymography, and net gelatinaseactivity in BALF assayed by digestion of fluorescein cou-pled gelatin, as previously described [12]. Densitometryof zymography gels was done using ... purposes)Flow cytometry quantitation of T lymphocytesFigure 6Flow cytometry quantitation of T lymphocytes. CD3+ CD4+ lymphocytes in (a) BALF & (b) LNs, and CD3+ CD8+ lym-phocytes in (c) BALF ... not infected with influenza and dark boxes denote mice infected with influenza. Panels a-h show protease activity in BALF. (a) Zymography of gelatinase activity at d3, (b) zymography of caseinolytic...
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Báo cáo y học: " Cigarette smoke induces IL-8, but inhibits eotaxin and RANTES release from airway smooth muscle" pot
... inflammation in cigarette smokers, where inflammatory cytokines,including TNFα, are usually present in the lung [28]. In mice, TNFα appears to be a central mediator for smoke- induced inflammation ... neutrophilicinflammation and release of proinflammatory mediators such as interleukin-8 (IL-8). Human airwaysmooth muscle cells (HASMC) are a source of proinflammatory cytokines and chemokines. Weinvestigated ... measured by enzyme-linked immunosorbent assay (ELISA) andgene expression by real time polymerase chain reaction (PCR). Data were analysed using one-wayanalysis of variance (ANOVA) followed by Bonferroni's...
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Tài liệu Báo cáo Y học: Systematic search for zinc-binding proteins in Escherichia coli potx
... N-terminal sequencing. In addition to five known zinc-binding proteins, nine zinc-binding proteins were newly identified including: acetatekinase (AckA), DnaK, serine hydroxymethyltransferase(GlyA), ... zinc-containing protein with thezinc finger or zinc cluster exist in yeast, which, however,lacks proteins with the hormone receptor-type zinc-bindingmotif. This type of zinc-binding proteins ... metal binding.Specificity of Zn(II) binding by the purifiedZn(II)-binding proteinsThe specificity of Zn(II) binding was also examined for thepurified Zn(II)-binding proteins. The binding of radioactiveZn(II)...
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