Báo cáo y học: "CD73 represses pro-inflammatory responses in human endothelial cells" pptx

... pro-inflammatory cytokines, although TNF-a production by endothelial cells is nor- mally only induced by inflammatory stimuli such as LPS or interleukin 1b [33,34]. In the future it would be inter- esting ... and increased endothelial permeability, resembling known responses to TNF- a . Conclusions: These results indicate that CD73 normally suppresses pro-inflammatory responses...

Ngày tải lên: 11/08/2014, 08:22

... Galéra P: Hypoxia-inducible factor-a inhibits the fibroblast-like markers type I and type III collagen during hypoxia-induced chondrocyte redifferentiation: Hypoxia not only induces type II collagen ... pathophysiological events occ urring in osteoarthritis. Finally, following such investigations, the identification of innovative strategies to maintain local in vivo oxygen percentages to...

Ngày tải lên: 12/08/2014, 11:23

... viral replication. Only a few studies investigated mucosal immune responses in controller individuals, but detailed mucosal immune analyses of intestinal lymphocytes from well-defined cohorts including HIV ... T-cell depletion in gut lymphoid tissue during primary human immunodeficiency virus type 1 infection and substantial delay in restoration following highly active antiretrovira...

Ngày tải lên: 13/08/2014, 01:20

... Everly GS Psychotraumatology In: Psychotraumatology: key papers and core concepts in post-traumatic stress (Edited by: Everly GS, Lating JM) New York, Plenum 1995, 3-15 4. American Psychiatric ... Furthermore, controlling for Type I errors inflates the chances of finding no significant differences when in fact they do exist (Type II error). Conclusions Many of the variables previously id...

Ngày tải lên: 08/08/2014, 20:23

... determined by genome-wide expression profiling [14]. Beyond direct cartilage destruction, RASFs maintain inflam- mation in synovial joints and induce chondrocyte dysfunction by releasing proinflammatory ... path- ways involved in cytokine/chemokine activity (cytokine- cytokine receptor interaction and Jak-STAT signalling), matrix remodelling (focal adhesion, TGF-β signalling, and ECM rece...

Ngày tải lên: 09/08/2014, 01:22

... gain insight into the signaling pathway activated by HNE in human OA osteoblasts, we first examined the HNE-induced phosphorylation patterns of MAPKs over increasing periods of time. Our data indicated ... metabolism and are regulated in bone by pro-inflammatory cytokines. The objective of this study was to investigate the role of HNE in OA osteoblast metabolism by determining its e...

Ngày tải lên: 09/08/2014, 08:22

... Cheng JZ, Singhal SS, Sharma A, Saini M, Yang Y, Awasthi S, Zim- niak P, Awasthi YC: Transfection of mGSTA4 in HL-60 cells pro- tects against 4-hydroxynonenal-induced apoptosis by inhibiting JNK-mediated ... articular chondro- cytes and as the main precursor for the synthesis of ECM gly- cosaminoglycans in cartilage [35,36]. The inhibition of proteoglycan synthesis in OA chondrocytes b...

Ngày tải lên: 09/08/2014, 13:21

... Sox9 stain- ing specificity was confirmed using human fetal growth plate cartilage, showing that the majority of cells in the surface, rest- ing, and proliferation zones positive and mostly negative ... patterns were mainly nuclear in normal cartilage (Figure 2), but Sox9 staining in OA clusters was present in both the cytoplasm and nucleus, or Figure 3 Stem cell markers in human...

Ngày tải lên: 09/08/2014, 14:21

... Working Party on Systemic Lupus Erythematosus: Morbidity and mortality in systemic lupus erythematosus during a 10- year period. A comparison of early and late manifestations in a cohort of 1000 ... ter- tiary teaching center associated with the University of the Basque Country – have been included in the ongoing pro- spective, observational study. Patient data since 1973 have been incl...

Ngày tải lên: 09/08/2014, 14:22

... model. Similarly, anti- inflammatory drugs minocycline and inodmethacin protected from LPS induced injury and attenuated NO generation. These data implicate the cytotoxicity imposed by LPS activated ... relatively selective iNOS inhibitor; LNMA: L-NNMA, a non selective NOS inhibitor APO: apocynin, a NADPH oxidase inhibitor; ALO: allopurinol, a xanthine oxidase inhibitor; INDO: indomethacin, a...

Ngày tải lên: 11/08/2014, 06:22