Báo cáo y học: " Histone deacetylase inhibitors induce apoptosis in human eosinophils and neutrophils" docx
Báo cáo y học: " Histone deacetylase inhibitors induce apoptosis in human eosinophils and neutrophils" docx
... G: Binding mode analysis of 3-(4-benzoyl-1-
methyl-1H-2-pyrrolyl)-N-hydroxy-2-propenamide: a new synthetic
histone deacetylase inhibitor inducing histone hyperacetylation, growth
inhibition, and ... c-jun-N-terminal kinase and PI3K-Akt pathway
inhibitors on TSA-induced apoptosis in human
eosinophils
c-jun-N-terminal kinase (JNK) and PI3K-Akt pathways
have been proposed t...
Báo cáo y học: "Histone deacetylase inhibitors modulate metalloproteinase gene expression in chondrocytes and block cartilage resorption" ppt
... collagenases, and
Figure 1
Histone deacetylase inhibitors block cartilage glycosaminoglycan and collagen loss induced by IL-1α/OSMHistone deacetylase inhibitors block cartilage glycosaminoglycan and
collagen ... 3
Histone deacetylase inhibitors abrogate IL-1α/OSM-induced expression of key metalloproteinase genesHistone deacetylase inhibitors abrogate IL-1α/OSM-induc...
Báo cáo y học: " Induction of multiple matrix metalloproteinases in human dermal and synovial fibroblasts by Staphylococcus aureus: implications in the pathogenesis of septic arthritis and other soft tissue infections" pdf
... during S. aureus infections. Calander and colleagues
[29], using wild-type S. aureus strain 8325-4 and its mutants
lacking aureolysin, serine protease, and cysteine protease,
demonstrated in ... expression of
a 92-kD gelatinase (type V collagenase) by rheumatoid syno-
vial fibroblasts and its induction in normal human fibroblasts
by inflammatory cytokines. J Clin Invest 1991, 88...
Báo cáo y học: "Histone deacetylase inhibitor, butyrate, attenuates lipopolysaccharide-induced acute lung injury in mice" pptx
... seemed to be pro-inflammatory in
ALI. In the present study, interestingly, our results indi-
cated that administration of butyrate in vivo attenuated
pulmonary inflammation in LPS-induced ALI. The ... and IL-1b showed the reduction of pul-
monary injury in ALI induced by LPS in mice [28,29].
In the present study, the concentrations of TNF-a and
IL-1b in BALF and the expr...
Báo cáo y học: "Histone deacetylase inhibition alters dendritic cells to assume a tolerogenic phenotype and ameliorates arthritis in SKG mice" docx
... Arthritis was induced in SKG mice by zymosan A injection. Trichostatin A, a histone deacetylase inhibitor,
was administered and its effects on arthritis were evaluated by joint swelling and histological ... performed by the scoring sys-
tem described previously, in which 0 = no inflammation,
1 = slight thickening of the synovial cell layer and/ or
some inflammatory cells in the...
Báo cáo Y học: The role of arginine residues in substrate binding and catalysis by deacetoxycephalosporin C synthase potx
... of the a-aminoadipoyl- side-chain
of penicillin N (1), with arginines 74 and 75 apparently
playing a less important role in side-chain binding. Taken
together, the results of this and previous ... contains eight arginine residues within, or close
to, its active site that may be involved in catalysis. Arg258
has already been shown by structural and mutagenesis
studies to bind the 5-c...
Báo cáo y học: "How safe are the biologicals in treating asthma and rhinitis" doc
... Interleukin-13 Inhibition
Interleukin-4 (IL-4) and Interleukin-13 (IL-13) are
cytokines that play a role in allergic inflammation by
inducing Th2 responses. Interleukin-4Rα is the signaling
component ... Clinical features
Type α High cytokine & cytokine release syndrome Symptoms will depend on the cytokine or cytokine being targeted e.g., high levels of
INF-α may cause 'flu-like...
Báo cáo y học: "The Short Anxiety Screening Test in Greek: translation and validation" ppsx
... rendering it practical for
use in everyday practice. According to the developers,
the instrument can accurately and reliably identify
symptoms of anxiety in older people even, and espe-
cially, in ... R:
Screening for depression and anxiety disorders in primary care patients.
Depress Anxiety 2006, 24:455-60.
12. Peveler R, Kilkenny L, Kinmonth AL: Medically unexplained physical...
Báo cáo y học: "A psychophysiological investigation of laterality in human emotion elicited by pleasant and unpleasant film clips" pptx
... was
evidence of excessive activity (including a premature
eyeblink) during the baseline period. They were also
rejected if there was no evidence of an eyeblink having
been evoked by the startle probe. Altogether, ... baseline EMG
and latency to response onset, only the findings on
affective ratings and startle amplitude are reported here.
Although no significant interaction effect appeare...
Báo cáo y học: "Potential involvement of oxidative stress in cartilage senescence and development of osteoarthritis: oxidative stress induces chondrocyte telomere instability and downregulation of chondrocyte function" pptx
... stress induces telomere instability
and dysfunction in chondrocytes, subsequently resulting in
cartilage ageing and the development of OA through a
mechanism involving the acceleration of chondrocyte
senescence. ... a tendency to maintain the
chondrocyte telomere length and proteoglycan remaining in the
cartilage explants, suggesting that oxidative stress induces
chondrocyte telom...