Báo cáo y học: "CCR5 signalling, but not DARC or D6 regulatory, chemokine receptors are targeted by herpesvirus U83A chemokine which delays receptor internalisation via diversion to a caveolin-linked pathway" pdf

... regulatory, chemokine receptors are targeted by herpesvirus U8 3A chemokine which delays receptor internalisation via diversion to a caveolin-linked pathway Julie Catusse, David J Clark and Ursula ... potentiate this activity, the viral chemokine can also avoid clearance by scavenger chemokine receptors, DARC and D6, which normally regulate an...

Ngày tải lên: 11/08/2014, 08:22

... 1998, 188:1521-1528. 6. Nieda M, Nicol A, Koezuka Y, Kikuchi A, Takahashi T, Nakamura H, Furukawa H, Yabe T, Ishikawa Y, Tadokoro K, et al.: Activation of human Valpha24NKT cells by alpha-glycosylceramide in a CD1d-restricted ... K, Hashimoto H, Yamamura T, Miyake S: Suppression of collagen-induced arthritis by natural killer T cell activation with OCH, a sphingosine-truncated ana...

Ngày tải lên: 09/08/2014, 06:22

... November 2007) doi:10.1111/j.1742-4658.2007.06209.x Ubiquitination and proteasomal degradation have recently emerged as an additional level of regulation of activated forms of Rho GTPases. To char- acterize this novel regulatory pathway and to gain ... cells, Rac1b is poorly ubiquitinated and appears to be much more resistant to proteasomal degradation than Rac1L61. Mutational analysi...

Ngày tải lên: 18/02/2014, 16:20

... monoclonal anti- body against prosaposin, monoclonal antibody against LRP ⁄ a2 MR, antibody against G a0 , or polyclonal antibody against calnexin (Sigma) overnight at 4 °C. All the antibody dilutions ... hypodiploid peak by PI stain- ing and cytofluorimetric analysis, as previously described [31]. Alternatively, apoptosis was also quantified by flow cytometry after double staining usin...

Ngày tải lên: 24/03/2014, 00:21

... mediator Competing interests The authors declare that they have no competing interests. Authors' contributions All authors contributed equally to the manuscript. All authors have read and approved ... Bacsi A, Choudhury BK, Dharajiya N, Alam R, Hazra TK, Mitra S, Goldblum RM, Sur S: ROS generated by pollen NADPH oxidase provide a signal that augments antigen-induced allergic airwa...

Ngày tải lên: 08/08/2014, 21:20

... Feld- mann M: Evidence that rheumatoid arthritis synovial T cells are similar to cytokine-activated T cells: involvement of phos- phatidylinositol 3-kinase and nuclear factor kappaB pathways in tumor ... receptor signalling subunit gp130 was sufficient to induce an autoimmune arthritis [3]. The gp130 subunit is shared by receptors not only for IL-6 itself, but also for leukaem...

Ngày tải lên: 09/08/2014, 01:23

... well as in other animal models of RA, the activation of JNK may be caused by another disease-relevant signalling pathway such as IL-1, which is a potential inducer of JNK phosphorylation in RA synovial ... synovial cells. In addition, growth factors such as epidermal growth factor, in concert with cell–cell and cell–matrix interactions, may contribute to JNK activation in human RA, na...

Ngày tải lên: 09/08/2014, 07:20

... 41:92-104. 139. Yasuda H, Shima N, Nakagawa N, Yamaguchi K, Kinosaki M, Mochizuki S, Tomoyasu A, Yano K, Goto M, Murakami A, Tsuda E, Morinaga T, Higashio K, Udagawa N, Takahashi N, Suda T: Osteoclast differentiation ... rheumatoid arthritis synovial T cells are similar to cytokine-activated T cells: involvement of phos- phatidylinositol 3-kinase and nuclear factor kappaB pathways in tu...

Ngày tải lên: 09/08/2014, 10:23

... Valladolid. Avenida Ramón y Cajal 3. 47005. Valladolid. Spain. 3 Department of Pharmacology and Therapeutics. Facultad de Medicina. Universidad de Valladolid. Avenida Ramón y Cajal 3. 47005. Valladolid. ... the chi-square expected value of at least one cell was less than 5. We avoided multicollinearity among the explanatory variables by performing collinearity diagnostic analyses. We pe...

Ngày tải lên: 10/08/2014, 09:23

... Dzienis-Straczkowska S, Stepien A, Kowalska I, Szelachowska M, Kinalska I: Plasma interleukin-8 concentrations are increased in obese subjects and related to fat mass and tumor necrosis factor -a system. ... human omen- tal fat explants are incubated in vitro. The effects of hypoxia in tissues appear to be mediated in part through HIF 1a, which is a major transcription factor th...

Ngày tải lên: 11/08/2014, 08:22