Báo cáo y học: " Alterations in transcriptional responses associated with vascular aging" ppsx

... increase in the levels of circulating cytokines, and in particular TNF-α during the process of aging. Sec- ond, vascular aging is associated with the increased pro- duction of reactive oxygen species ... in vascular inflammation and aging Transcription Factors Pro-/Anti-inflammatory Selected Target Genes Alterations with Aging NF-κB Pro-inflammatory MCP-1, ICAM-1, NOS2 Incre...

Ngày tải lên: 11/08/2014, 08:22

... previous experiments [17]. Induction of lung injury by bleomycin Mice recei ved a single intrat racheal instillati on of saline (0.9% w/v) or saline containing bleomyci n sulphate (1 mg/kg body weight) at ... lung injury caused by bleomycin administration was associated with a significant loss in body weight, while AM treatment significantly attenuated the loss in body weight (Figure...

Ngày tải lên: 12/08/2014, 13:22

... cirrhosis, is manifested by dyspnea, platypnea and orthopnea and nowadays is more widely diagnosed occurring in chronic liver disease of all types and mainly in severe suffering patients [4, 9, ... partly involved in the development of hy- poxemia, though some studies are arguing whether or not hypoxemia develops in patients with intrapul- monary vasodilatation [15, 16]. In ou...

Ngày tải lên: 08/08/2014, 18:20

... proteins. It is a complex cascade involving proteolytic cleavage of serum glycoproteins often activated by cell receptors. This cascade ultimately results in induction of the antibody responses, inflam- mation, ... depleted serumwasobtainedbyincubationofguineapigserum with 150 mM NH 4 OH for 45 min at 37°C. The effi- ciency of depletion (≥ 95%) was judged by ELISA. Hovhannisyan et al. Al...

Ngày tải lên: 08/08/2014, 21:20

... (FITC), phycoerythrin (PE), peridinin-chlorophyll-protein Cy5.5 (PerCpCy5.5) or allophycocyanin (APC) conjugated mAb specific for the following human cell surface markers: anti-CD19 PerCpCy5.5, anti-CD27 ... is a chronic systemic autoimmune disease, characterised by inflammatory polyarthritis and joint damage resulting in progressive disability [1]. The inflamma- tory infiltrate in RA inc...

Ngày tải lên: 09/08/2014, 14:21

... albeit involving different dinucleotides. The same periodic RR/YY dinucleotide frequency is seen in human and mouse promoters, but interestingly the medaka fish Oryzias latipes displays a strong ... S1B in Additional file 1; see Materials and methods) and found that mainly purine- purine (RR) and pyrimidine-pyrimidine (YY) dinucle- otides contribute to the periodic signal (Figure 1a, inse...

Ngày tải lên: 09/08/2014, 20:22

... Receptor Binding Studies Using [ 3 H] 5-Hydroxytryptamine 5-HT receptor assay was done using [ 3 H] 5-hydroxy- tryptamine binding in crude synaptic membrane pre- parations of hippocampus by the modified ... potentiating of insulin effect of plasma by increasing the pancreatic secretion of insulin from existing b-cell or its release from bound insulin intercede by increase in t he insulin...

Ngày tải lên: 10/08/2014, 05:21

... healthy subjects. A larger capillary network is associated with oxidative type I fibres compared to gly- colytic type IIa fibres, which may explain why alterations in CFPE-index are more evident in ... significantly altered in COPD patients [8,9,13]. This finding can be explained by a reduction in fibre area as previously shown in COPD patients [10]. This is also in line wi...

Ngày tải lên: 12/08/2014, 11:22

... [26]. Other genes encoding proteins with RNA splicing/binding and RNA transport activity were also up regulated during this period, including the methylated mRNA cap binding proteins EIF4G1 [27] and ... protein induced by growth stimulation or protein synthesis inhibition thought to be involved in splicing and nuclear export, with homology to the yeast Sub2p protein [36], were different...

Ngày tải lên: 13/08/2014, 13:20

... of NVP- induced rash were reportedly observed mainly in patients whose CD4 counts were over 250 cells/μl [29]. Accord- ingly, nearly all of patients in our study started NVP-con- taining regimen ... HLA-Cw*04 is associated with rash in nevirapine treated Thais. Future screening of patients' HLA may reduce the number of nevirapine-induced rash cases, and patients with alleles...

Ngày tải lên: 10/08/2014, 05:21