Báo cáo y học: "Cigarette smoke regulates the expression of TLR4 and IL-8 production by human macrophages" pdf

... equally conceived of the study, and partici- pated in the design of the study and performed immu- noassays, FACS analysis, statistical analysis, and wrote the first draft and final version of the ... CSM. CSM regulates phosphorylation of IRAK and degradation of IκB-α by MDMs and phosphorylation of IRAK in HEK cellsFigure 6 CSM regulates phosphorylation...

Ngày tải lên: 11/08/2014, 08:22

... struc- ture and tissue repair [1]. Cigarette smoke (CS)-induced emphysema is characterized by enlargement of the air- spaces and a loss of alveolar structure [2,3] . Endothelial cell death and the regression ... recent study suggested that VEGFR2 is post-translationally modified by ROS/ RNS present or derived by CS [30]. The pro-apoptotic Bad is the primary target o...

Ngày tải lên: 11/08/2014, 08:22

... expression of the procollagen hydroxylases. With the exception of PDI, which is known to be induced by the UPR [41], however, none of the other enzymes was relevantly induced by the UPR, supporting the ... functional cluster of genes by the oxygen tension has already been found for the enzymes involved in the glycolytic cascade [29] and also for the key p...

Ngày tải lên: 20/02/2014, 02:21

... of the study. AL was involved with the design and coordination of the study, drafting and editing of the manuscript. Acknowledgements The present study was supported by operating grants 14095 and ... immortalized chondrocytes is reduced by inhibition of MEK1/2 signalling [10]. TNF may therefore regulate the expression of a subset of genes by alterations...

Ngày tải lên: 09/08/2014, 01:22

... component in the uptake and processing of luminal antigens. Such uptake may occur by endocytosis or by phagocytosis after passage of antigen through M cells. The DCs then present the processed ... identification of such DC subsets has led to a better understanding of their distribution and function in the body. In this review, several key properties of the immunobi...

Ngày tải lên: 11/08/2014, 10:23

... that oxygen acts as a molecular switch and alters the expression of the two nuclear genome coded isoforms of CytOX V [10,32]. The regulation of genes CytOX5a and CytOX5b, coding for the two isofoms ... characteristics of the enzyme following heme reduction. These studies suggested that heme might regulate not only the mammalian CytOX gene expression but also the...

Ngày tải lên: 20/02/2014, 23:20

... their expression may lead to the alteration of both the formation and targeting of these complexes. Consequently, an oxidant-mediated reduction in the protein expression of Mi-2α and mSin3a and ... com- plexes and thereafter their roles in disease. In summary cigarette smoke exposure reduced HDAC- 2 activity and the expression of mSin3a and Mi-2α in the l...

Ngày tải lên: 11/08/2014, 03:20

... our understanding of the roles of these co-repressor com- plexes and thereafter their roles in disease. In summary cigarette smoke exposure reduced HDAC- 2 activity and the expression of mSin3a and ... (encoded by the Chd3 gene) and Mi-2β (encoded by the Chd4 gene). Although the latter is predominantly associated with the NuRD complex they are structurally si...

Ngày tải lên: 11/08/2014, 06:22

... hypertrophy, inflammatory cells in the bronchoalveolar lavage fluid (BALF) and lung tissue and by determining the cytokine and chemokine profiles in the BALF of A/J mice exposed to cigarette smoke ... properly cited. elevated levels of T-lymphocytes, in particular CD8+ cells, in lung parenchyma and airways [11-14]. Migra- tion and activation of inflammatory cells to...

Ngày tải lên: 12/08/2014, 11:22